The effect of cancer-associated fibroblast in glucose metabolism of tumor cells

doi:10.19438/j.cjoms.2021.01.014

Abstract

Abstract: ] Warburg effect described a phenomenon that tumor cells undergoing aerobic glycolysis even with enough oxygen, generating lactic acid and little ATP. Although it had a low efficiency of energy production, lactic acid and other products may work as intermediates to modify tumor microenvironment and promote tumor progression. Recently, it's reported that fibroblasts, an important part of tumor stroma, were endowed with cancer-associated fibroblast (CAF) phenotype such as undergoing aerobic glycolysis, mitophagy and mitochondrial dysfunction. CAF provided lactic acid and other intermediates as building blocks for macromolecule anabolism, which could facilitate tumor proliferation, invasion, metastasis and drug resistance. On the contrary, tumor cells obtained activated oxidative phosphorylation and mitochondrial metabolism, which was named as "reverse Warburg effect". The two theory unveiled a metabolic flexibility and cross-talk among tumor cells and acidic tumor microenvironment, which facilitates tumor progression.

Key words: Cancer-associated fibroblast, Glycolysis, Warburg effect, Tumor microenvironment

CLC Number:

R739.8

LI Ming-yu, MA Hai-long, YANG Xi, ZHANG Zhi-yuan. The effect of cancer-associated fibroblast in glucose metabolism of tumor cells[J]. China Journal of Oral and Maxillofacial Surgery, 2021, 19(1): 70-75.

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