Repair of bone defect by using mineralized collagen materials and collagen membrane in minipig models

doi:10.19438/j.cjoms.2017.05.006

Abstract

Abstract: PURPOSE: The aim of this study was to compare the clinical and histologic outcomes of bone regeneration using two different graft materials: deproteinized bovine bone mineral (Bio-Oss) and mineralized collagen bone materials (ChiBei) with absorbable collagen membrane, thus to evaluate the effect of ChiBei on bone regeneration. METHODS: The molars of the minipig were extracted, a 10mm×10mm bone defect was created. Bone defect was filled with Bio-Oss and ChiBei respectively and with absorbable collagen membrane as well. Cone-beam CT (CBCT) was taken 12 weeks after surgery and bone samples were stained with Goldner's Trichrome. The new regenerated area was calculated by the image analysis software Image-Pro plus 6.0 and the percentages of newly formed bone were compared between two groups using SPSS 22.0 software package. RESULTS: Bone defect was filled with new regenerated bone in each group. There was no significant difference in bone density between the ChiBei and Bio-Oss group on CBCT, so did the histologic analysis results. CONCLUSIONS: Based on the findings of the study, we speculated ChiBei materials covered with collagen membrane have positive effect on bone regeneration after tooth extraction, but more researches need to be carried out.

Key words: Site preservation, Bone defect regeneration, ChiBei materials, Guided bone regeneration

CLC Number:

R782.1

WANG Piao, YAO Yao, ZHAO Hao, PAN Ju-li, CUI Fu-zhai，GUO Ya-juan.. Repair of bone defect by using mineralized collagen materials and collagen membrane in minipig models[J]. China Journal of Oral and Maxillofacial Surgery, 2017, 15(5): 408-412.

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