Abstract: PURPOSE: To investigate the efficacy and safety of music therapy in sedation and analgesia of patients with endotracheal intubation after orthognathic surgery. METHODS: Ninety patients undergoing orthognathic surgery were randomly divided into 3 groups, 30 in each group. Patients in groups A and B received treatment of sedation and analgesia with dexmedetomidine at 0.4 μg/(kg·h) and 0.8 μg/(kg·h), respectively; while patients in group C were given dexmedetomidine with 0.4 μg/(kg·h) + music therapy. The general conditions were recorded and average blood pressure, heart rate, sedation and analgesia scores at 3 h(T1), 6 h(T2), 9 h(T3) and 12 h(T4) in ICU after operations were also observed. The incidence of adverse reactions was compared among the 3 groups. The data were analyzed using GraphPad Prism 5 software package. RESULTS: The mean blood pressure of group A and group C was significantly higher than that of group B at T2, T3 and T4 time points, the heart rate of patients in group A and group C was significantly higher than that of patients in group B at each time point (P<0.05). Ramsay sedation score of patients in group B and group C was significantly higher than that of group A at all time points, while VAS pain score was significantly lower than that of group A (P<0.05). The incidence of bradycardia and hypotension in group C was significantly lower than that in group B (P<0.05). CONCLUSIONS: Music therapy can reduce the use of dexmedetomidine in patients with endotracheal intubation after orthognathic surgery. It has definite effect of assistant sedation and analgesia, and can reduce the incidence of adverse drug reactions.

Key words: Music therapy, Orthognathic surgery, Sedation and analgesia, Stress response