China Journal of Oral and Maxillofacial Surgery ›› 2021, Vol. 19 ›› Issue (1): 45-48.doi: 10.19438/j.cjoms.2021.01.009

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Analysis of anesthetic effect of remifentanil combined with ketamine in cleft lip and palate surgery in infants

LIN Xiao-rui1, LI Chen-xi2, ZHANG Xiu-hua1   

  1. 1. Central Operation Department, The First Affiliated Hospital of Xinjiang Medical University. Urumqi 830054, Xinjiang Uygur Autonomous Region, China;
    2. Department of Oral and Maxillofacial Surgery, Laboratory for Tumor Genetics and Regenerative Medicine, The Head and Neurocenter, University Hospital Hamburg-Eppendorf (UKE). Hamburg 20246, Germany
  • Received:2020-03-09 Revised:2020-08-24 Online:2021-01-20 Published:2021-02-19

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Abstract: PURPOSE: To observe and analyze the anesthetic effect of remifentanil combined with ketamine in cleft lip and palate surgery of infants. METHODS: Ninety-six infants who underwent repair of congenital cleft lip and palate in our hospital from December 2017 to December 2019 were selected, the children were randomly divided into an experimental group (n=48) and a control group (n=48) according to the order of admission. Patients in the control group were anesthetized with ketamine alone, while patients in the experimental group were anesthetized by remifentanil combined with ketamine. The blood pressure, heart rate, and anesthesia recovery time were used to evaluate the anesthetic effect of the two groups of children and the amount of applied ketamine was recorded. SPSS 22.0 software package was performed for statistical analysis. RESULTS: There was no significant difference in the respiration and blood oxygen saturation between the two groups of children during and after surgery (P>0.05). There was no significant difference in heart rate and mean arterial pressure between the two groups of children before operation. The heart rate and mean arterial pressure of the children in the experimental group were significantly lower than those in the control group during and after surgery (P<0.05). The anesthesia wake-up time of the experimental group was significantly shorter than that of the control group, and the amount of applied ketamine was significantly lower than that of the control group. The incidence of respiratory depression, increased airway secretion, and agitation was significantly lower than that of the control group(P<0.05). There was no significant difference in the incidence of adverse reactions such as vomiting, laryngeal spasm, asphyxia and fever between the two groups of children (P>0.05). CONCLUSIONS: Remifentanil combined with ketamine as an anesthetic for cleft lip and palate repair in infants and young children could improve blood pressure, heart rate, shorten anesthesia recovery time, reduce respiratory depression and decrease airway secretions while maintaining stable blood oxygen saturation. Moreover, its analgesic effect is exact and the safety is high.

Key words: Remifentanil, Ketamine, Infants, Cleft lip and palate, Anesthetic effect

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