Adenoid cystic carcinoma of salivary gland: a clinicopathological study of 474 consecutive cases

Abstract

Abstract: PURPOSE: To investigate the clinicopathological features of salivary adenoid cystic carcinoma (ACC) in 474 Chinese patients. METHODS: The clinical and pathological characteristics of 474 primary salivary ACC diagnosed in Department of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine were analyzed. SPSS18.0 software package was used for statistical analysis. RESULTS: Of the 474 ACC cases, the male-to-female ratio was 1.03:1 (240 to 234); the mean age was 52 years (from 11 to 83); the parotid and the palate were the most common locations of major and minor salivary gland respectively; the mean clinical course was 21 months (from 1 month to 37 years); 64% (301/474) patients had clinical symptom; 72%(343/474) patients were TNM stage Ⅱ and Ⅲ; 76%(360/474) patients had cribriform and tubular histological subtype. Tumor with solid pattern was associated with higher cervical lymph node metastasis (P=0.016). CONCLUSIONS: In Chinese population, ACC is more common in elder people and frequently involves the parotid gland and the palate. Most patients have clinical symptoms and histologically, cribriform and tubular types are more common. Patients with solid pattern have higher possibility to develop cervical lymph node metastasis than those with cribriform and tubular patterns.

Key words: Salivary gland, Adenoid cystic carcinoma, Clinicopathological analysis

CLC Number:

R739.8

ZHANG Chun-ye, DENG Xu-xia, TIAN Zhen, WANG Li-zhen, HU Yu-hua, LI Lei, LI Jiang. Adenoid cystic carcinoma of salivary gland: a clinicopathological study of 474 consecutive cases[J]. China Journal of Oral and Maxillofacial Surgery, 2014, 12(2): 126-130.

References

[1] Li J, Wang BY, Nelson M, et al. Salivary adenocarcinoma, not otherwise specified: a collection of orphans [J]. Arch Pathol Lab Med, 2004, 128(12): 1385-1394.
[2] Tian Z, Li L, Wang L, et al. Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6982 cases in an eastern Chinese population [J]. Int J Oral Maxillofac Surg, 2010, 39(3): 235-242.
[3] Ellington CL, Goodman M, Kono SA, et al. Adenoid cystic carcinoma of the head and neck: incidence and survival trends based on 1973-2007 Surveillance, Epidemiology, and End Results data [J]. Cancer, 2012, 118(18): 4444-4451.
[4] da Cruz Perez DE, de Abreu Alves F, Nobuko Nishimoto I, et al. Prognostic factors in head and neck adenoid cystic carcinoma [J]. Oral Oncol, 2006, 42(2): 139-146.
[5] Ciccolallo L, Licitra L, Cantu G, et al. Survival from salivary glands adenoid cystic carcinoma in European populations [J]. Oral Oncol, 2009, 45(8): 669-674.
[6] Kokemueller H, Eckardt A, Brachvogel P, et al. Adenoid cystic carcinoma of the head and neck-a 20 years experience [J]. Int J Oral Maxillofac Surg, 2004, 33(1): 25-31.
[7] Barnes L. World health organization classification of tumours: pathology and genetics head and neck tumours [M]. Lyon: IARC press, 2005.
[8] Huang M, Ma D, Sun K, et al. Factors influencing survival rate in adenoid cystic carcinoma of the salivary glands [J]. Int J Oral Maxillofac Surg, 1997, 26(6): 435-439.
[9] Perzin KH, Gullane P, Clairmont AC. Adenoid cystic carcinomas arising in salivary glands: a correlation of histologic features and clinical course [J]. Cancer, 1978, 42(1): 265-282.
[10] Bianchi B, Copelli C, Cocchi R, et al. Adenoid cystic carcinoma of intraoral minor salivary glands [J]. Oral Oncol, 2008, 44(11): 1026-1031.
[11] Khan AJ, DiGiovanna MP, Ross DA, et al. Adenoid cystic carcinoma: a retrospective clinical review [J]. Int J Cancer, 2001, 96(3): 149-158.
[12] Garden AS, Weber RS, Morrison WH, et al. The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation [J]. Int J Radiat Oncol Biol Phys, 1995, 32(3): 619-626.
[13] Mücke T, Tannapfel A, Kesting MR, et al. Adenoid cystic carcinomas of minor salivary glands [J]. Auris Nasus Larynx, 2010, 37(5): 615-620.
[14] Agarwal JP, Jain S, Gupta T, et al. Intraoral adenoid cystic carcinoma: prognostic factors and outcome [J]. Oral Oncol, 2008, 44(10): 986-993.
[15] Min R, Siyi L, Wenjun Y, et al. Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis: a preliminary study of 62 cases [J]. Int J Oral Maxillofac Surg, 2012, 41(8): 952-957.