Clinical analysis of 13 649 cases of parotid gland tumors in southeast China

doi:10.19438/j.cjoms.2024.06.012

Abstract

Abstract: PURPOSE: To analyze the pathological types and composition ratios of tumors within the parotid gland in order to provide data for epidemiological support. METHODS: Patients diagnosed with parotid tumors were recruited from Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine between 2005 to 2022. The patient sex, age and tumor type were collected. RESULTS: Totally 13 649 cases were enrolled in this study. The patients’ age ranged from 1 to 104 years, with the peak age occurring in the sixth decade. The male to female ratio was 1.3∶1. Among of them, totally 11 008 were benign tumors (80.7%), and 2 641(19.3%) were intermediate/malignant tumors. A total of 12 856 cases (94.2%) originated from epithelium, while 454 cases (3.3%) from soft tissues and 339 cases (2.5%) from haematopoietic and lymphoid tissues. Among 12 228 cases of primary salivary gland tumors, totally 10 289 (84.1%) of them were benign and 1 939(15.9%) were malignant. Pleomorphic adenoma and carcinoma ex pleomorphic adenoma were the most common benign and malignant subtype, respectively. Nasopharyngeal lymphoepithelial carcinoma was the most prevalent among different types of metastatic tumors to the parotid gland. The most common soft tissue and haematopoietic and lymphoid tissue tumor in the parotid gland were Schwannoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma(MALT lymphoma). CONCLUSIONS: In southeastern region of China, parotid tumors, pleomorphic adenoma and carcinoma ex pleomorphic adenoma are the most common benign and malignant tumors of the parotid gland. The most prevalent soft tissue tumors and lymphoid hematopoietic system tumors are Schwannoma and MALT lymphoma, respectively.

Key words: Parotid gland tumor, Tumor composition, Epidemiology, Southeastern region of China

CLC Number:

R739.8

GU Ting, SUN Jing-jing, WANG Yu, TIAN Zhen, WANG Li-zhen, HU Yu-hua, XIA Rong-hui, LI Jiang, ZHANG Chun-ye. Clinical analysis of 13 649 cases of parotid gland tumors in southeast China[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(6): 590-596.

References

[1] Maahs GS, Oppermann Pde O, Maahs LG, et al.Parotid gland tumors: a retrospective study of 154 patients[J]. Braz J Otorhinolaryngol, 2015, 81(3): 301-306.
[2] Shashinder S, Tang IP, Velayutham P, et al.A review of parotid tumours and their management: a ten-year-experience[J]. Med J Malaysia, 2009, 64(1): 31-33.
[3] Sungur N, Akan IM, Ulusoy MG, et al.Clinicopathological evaluation of parotid gland tumors: a retrospective study[J]. J Craniofac Surg, 2002, 13(1): 26-30.
[4] Ascani G, Pieramici T, Messi M, et al.Salivary glands tumours: a retrospective study of 454 patients[J]. Minerva Stomatol, 2006, 55(4): 209-214.
[5] Tian Z, Li L, Wang L, et al.Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6 982 cases in an eastern Chinese population[J]. Int J Oral Maxillofac Surg, 2010, 39(3): 235-242.
[6] EI-Naggar AK, Chan JKC, Grandis JR, et al.WHO classification of head and neck tumours[M]. 4th Ed. Lyon: IARC, 2017.
[7] Badlani J, Gupta R, Smith J, et al.Metastases to the parotid gland-a review of the clinicopathological evolution, molecular mechanisms and management[J]. Surg Oncol, 2018, 27(1): 44-53.
[8] Sun J, Wang L, Tian Z, et al.Higher Ki67 index, nodal involvement, and invasive growth were high risk factors for worse prognosis in conventional mammary analogue secretory carcinoma[J]. J Oral Maxillofac Surg, 2019, 77(6): 1187-1202.
[9] Zhang C, Gu T, Hu Y, et al.Reevaluation of salivary lymphadenoma: a subgroup identified as warthin-like mucoepidermoid carcinoma following molecular investigation for MAML2 rearrangement[J]. Arch Pathol Lab Med, 2021, 145(6): 744-752.
[10] 张亮, 张莉, 刘华, 等. 312 例腮腺区肿瘤临床回顾性分析[J]. 临床口腔医学杂志, 2022, 38(9): 534-537.
Zhang L, Zhang L, Liu H, et al.Retrospective clinical analysis of parotid gland tumor in 312 patients[J]. Journal of Clinical Stomatology, 2022, 38(9): 534-537.
[11] 庞亚倩, 张凯, 刘姗姗,等. 344 例腮腺肿瘤回顾性分析[J]. 齐齐哈尔医学院学报, 2020, 41(24): 3111-3115.
Pang YQ, Zhang K, Liu SS, et al.Retrospective analysis of 344 cases of parotid gland tumors[J]. Journal of Qiqihar Medical University, 2020, 41(24): 3111-3115.
[12] 赵志国, 高丹, 王瑾, 等. 896例腮腺肿瘤临床回顾分析[J]. 上海口腔医学, 2017, 26(6): 605-609.
Zhao ZG, Gao D, Wang J, et al.Retrospective analysis of 896 cases of parotid gland tumor[J]. Shanghai Journal of Stomatology, 2017, 26(6): 605-609.
[13] Drivas EI, Skoulakis CE, Symvoulakis EK, et al. Pattern of parotid gland tumors on Crete, Greece: a retrospective study of 131 cases[J]. Med Sci Monit, 2007, 13(3): CR136-140.
[14] Venkatesh S, Srinivas T, Hariprasad S.Parotid gland tumors: 2-year prospective clinicopathological study[J]. Ann Maxillofac Surg, 2019, 9(1): 103-109.
[15] Li LJ, Li Y, Wen YM, et al.Clinical analysis of salivary gland tumor cases in West China in past 50 years[J]. Oral Oncol, 2008, 44(2): 187-192.
[16] 邓明辉, 吴汉江. 湖南地区5 443 例口腔颌面部恶性肿瘤临床分析[J]. 中国口腔颌面外科杂志, 2010, 8(2): 144-148.
Deng MH, Wu HJ.Clinical analysis of 5 443 malignant oral and maxillofacial tumors in Hunan area[J]. China Journal of Oral and Maxillofacial Surgery, 2010, 8(2): 144-148.
[17] 罗志强, 南晓梅, 叶钟泰. 2 085例口腔颌面部肿瘤疾病构成比分析[J]. 国际口腔医学杂志, 2015, 42(6): 635-639.
Luo ZQ, Nan XM, Ye ZT.Analysis of the proportion of oral-maxillofacial tumors in 2 085 patients[J]. International Journal of Stomatology, 2015, 42(6): 635-639.
[18] Skálová A, Vanecek T, Sima R, et al.Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity[J]. Am J Surg Pathol, 2010, 34(5): 599-608.
[19] Alves LDB, de Melo AC, Farinha TA, et al. A systematic review of secretory carcinoma of the salivary gland: where are we?[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2021, 132(4): e143-e152.
[20] McCarthy WA, Cox BL. Intraparotid schwannoma[J]. Arch Pathol Lab Med, 2014, 138(7): 982-985.
[21] Gu T, Zhang C, Xia R, et al.Indicators for malignant transformation in patients with lymphoepithelial lesion[J]. J Oral Maxillofac Surg, 2021, 79(4): 836-844.
[22] Zhang C, Xia R, Gu T, et al.Clinicopathological aspects of primary mucosa-associated lymphoid tissue lymphoma of the salivary gland: a retrospective single-center analysis of 72 cases[J]. J Oral Pathol Med, 2021, 50(7): 723-730.