The clinical effect of concentrate growth factor combined with autogenous bone and Bio-Oss on the long-term stability of alveolar bone repair after mandibular third molar extraction

doi:10.19438/j.cjoms.2024.06.005

Abstract

Abstract: PURPOSE: To evaluate the clinical efficacy of concentrate growth factors(CGF) combined with autobone and Bio-Oss in the long-term stability of alveolar bone repair after mandibular third molar extraction. METHODS: Sixty-six patients who underwent extraction of mandibular third molars at Tongren Hospital of Shanghai Municipality from September 2020 to December 2021 were selected and divided into 3 groups, blank group(n=22), experimental group A (autogenous bone, Bio-Oss, and oral repair film, n=23), and experimental group B(autogenous bone, Bio-Oss, CGF gel + CGF film, n=21). The Postoperative Symptom Severity Scale (PoSSe) was used to assess the clinical symptoms of the 3 groups of patients 1 week postoperatively. Additionally, probing depth (PD), vertical and horizontal distances of bone resorption were measured 3, 6, and 12 months postoperatively for the distal aspect of the second molar. SPSS 19.0 software package was used for data analysis. RESULTS: CGF could significantly reduce the pain time after tooth extraction (P<0.05). PD of the experimental group B was significantly lower than that of the blank group 3, 6 and 12 months after surgery(P<0.05), and significantly lower than that of the experimental group A 12 months postoperatively(P<0.05). At 3 and 6 months after operation, the vertical height of bone defect absorption in the experimental group B was significantly lower than that in the experimental group A(P<0.05). In terms of the horizontal distance of bone defect absorption, at 3, 6 and 12 months after surgery, the results of the experimental group B were significantly lower than those of the blank group(P<0.05); at 3 months after surgery, the experimental group B was significantly lower than the experimental group A(P<0.05), but at 6 and 12 months after surgery, there was no significant difference between the two groups (P>0.05). CONCLUSIONS: Autologous bone and Bio-Oss can achieve good results in restoration of alveolar bone after mandibular third molar extraction, but CGF combined with autologous bone and Bio-Oss has better clinical efficacy and is worthy of recommendation.

Key words: Mandibular third molar, Bone defect, CGF, Bio-Oss, Probing depth, PoSSe

CLC Number:

R782.1

SUN Shou-fu, PAN Yu-fan, TANG Yu, WANG Wei, JIANG Xue-wei, JIANG Yu-nan. The clinical effect of concentrate growth factor combined with autogenous bone and Bio-Oss on the long-term stability of alveolar bone repair after mandibular third molar extraction[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(6): 547-552.

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