Nutritional status and quality of life in 28 patients with advanced oral squamous cell carcinoma during neoadjuvant chemotherapy

doi:10.19438/j.cjoms.2020.06.009

Abstract

Abstract: PURPOSE: To explore the changes of nutritional status and quality of life in patients with advanced oral squamous cell carcinoma(OSCC) during neoadjuvant chemotherapy and their correlation, and evaluate the effect of chemotherapy on nutritional status and quality of life. METHODS: During June 2019 to December 2019, 28 patients with advanced OSCC who received neoadjuvant chemotherapy in the Department of Oromaxillofacial Head and Neck Oncology of Shanghai Ninth People's Hospital were enrolled in the cohort study. TPF regimen (docetaxel+cisplatin+5-fluorouracil) was used in the whole group. During chemotherapy, individual regimen was used for nutritional support. The changes of PG-SGA, QLQ-H&N35 scores and their correlation before and after the chemotherapy were analyzed. The patients were divided into the response group (CR+PR) and the non-response group (PD+SD) for stratified analysis according to the tumor regression using SPSS 23.0 software package. RESULTS: The PG-SGA score and QLQ-H&N35 score of patients after chemotherapy were significantly lower than those before chemotherapy(P=0.0301; P=0.0015), and there was significant correlation between them(r=0.5953, P<0.0001). Stratified analysis showed that there was no significant difference in PG-SGA score and QLQ-H&N35 score between response group and non-response group(P>0.05). There was no significant difference in body weight, muscle mass and fat mass between the two groups (P>0.05). There was no significant difference in body weight and fat between the two groups(P>0.05), but there was significant increase in muscle mass in response group and significant decrease in muscle mass in the non-response group(P=0.0358). CONCLUSIONS: Neoadjuvant chemotherapy can improve the nutritional status and quality of life of patients with advanced OSCC.

Key words: Advanced oral cancer, Neoadjuvant chemotherapy, Nutritional status, Quality of life

CLC Number:

R739.8

ZHANG Xin-rui, JIANG Yi-ting, ZHANG Han-zhi, ZHANG Mei-fang, ZHANG Hai-feng, SUN Juan, REN Guo-xin. Nutritional status and quality of life in 28 patients with advanced oral squamous cell carcinoma during neoadjuvant chemotherapy[J]. China Journal of Oral and Maxillofacial Surgery, 2020, 18(6): 516-520.

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