唾液腺黏液表皮样癌预后评估的组织病理学与分子病理指标

doi:10.19438/j.cjoms.2018.04.016

中国口腔颌面外科杂志 ›› 2018, Vol. 16 ›› Issue (4): 376-381.doi: 10.19438/j.cjoms.2018.04.016

唾液腺黏液表皮样癌预后评估的组织病理学与分子病理指标

汪洋, 田臻

上海交通大学医学院附属第九人民医院·口腔医学院口腔病理科,国家口腔疾病临床研究中心, 上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011

收稿日期:2017-06-29 修回日期:2017-09-27 出版日期:2018-07-20 发布日期:2018-08-09
通讯作者: 田臻,E-mail：tian0304_cn@163.com
作者简介:汪洋（1989-）,男,在读硕士研究生,E-mail：cmfuyangwang@126.com
基金资助:
国家自然科学基金（81272976、81372910）

Histopathological and molecular markers in prognostic evaluation of salivary mucoepidermoid carcinoma

WANG Yang, TIAN Zhen

Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011, China;

Received:2017-06-29 Revised:2017-09-27 Online:2018-07-20 Published:2018-08-09

摘要/Abstract

摘要： 黏液表皮样癌（mucoepidermoid carcinoma,MEC）是最常见的唾液腺恶性肿瘤,曾一度被认为良性肿瘤而称作黏液表皮样瘤。虽然MEC均由黏液细胞、中间细胞和表皮样细胞构成,但其临床生物学行为表现各异,可分为低度恶性、中度恶性和高度恶性。客观准确地评价MEC的恶性级别,对于临床上确定治疗方案具有重要的指导意义。近年来陆续筛选出的若干预后相关分子标志物,有望与传统组织病理学分级相结合,形成有助于完善MEC预后评估的评价体系。

关键词: 黏液表皮样癌, 融合基因, MECT1-MAML2, 唾液腺

Abstract: Mucoepidermoid carcinoma (MEC） is the most common salivary gland malignancies, which used to be classified as mucoepidermoid tumor. Although MEC is composed basically of 3 different cell types: a mucin-producing cell, an epidermoid cell, and an intermediate cell, MEC may have different biological behaviors, which can be divided into low, moderate, and high grade. It is important to distinguish the histopathologic grade, in order to make appropriate treatment plan. In recent years, several prognostic molecular markers have been discovered, which are expected to be combined with the traditional histopathological classification to form a rating system for improving prognosis assessment of MEC.

Key words: Mucoepidermoid carcinoma, Fusion gene, MECT1-MAML2, Salivary gland

中图分类号:

R739.8

汪洋, 田臻. 唾液腺黏液表皮样癌预后评估的组织病理学与分子病理指标[J]. 中国口腔颌面外科杂志, 2018, 16(4): 376-381.

WANG Yang, TIAN Zhen. Histopathological and molecular markers in prognostic evaluation of salivary mucoepidermoid carcinoma[J]. China J Oral Maxillofac Surg, 2018, 16(4): 376-381.

参考文献

[1] El-Naggar A, Chan J, Grandis J, et al.WHO classification of head and neck tumours[M]. Lyon, France: IARC, 2017: 163-164.
[2] McHugh CH, Roberts DB, El-Naggar AK, et al. Prognostic factors in mucoepidermoid carcinoma of the salivary glands[J]. Cancer, 2012, 118(16): 3928-3936.
[3] Seifert G, Sobin LH.The World Health Organization's histological classification of salivary gland tumors. A commentary on the second edition[J]. Cancer, 1992, 70(2): 379-385.
[4] Auclair PL, Goode RK, Ellis GL.Mucoepidermoid carcinoma of intraoral salivary glands. Evaluation and application of grading criteria in 143 cases[J]. Cancer, 1992, 69(8): 2021-2030.
[5] Brandwein MS, Ivanov K, Wallace DI, et al.Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading[J]. Am J Surg Pathol, 2001, 25(7): 835-845.
[6] Batsakis JG, Luna MA.Histopathologic grading of salivary gland neoplasms: I. Mucoepidermoid carcinomas[J]. Ann Otol Rhinol Laryngol, 1990, 99(10 Pt 1): 835-838.
[7] Healey WV, Perzin KH, Smith L.Mucoepidermoid carcinoma of salivary gland origin. Classification, clinical-pathologic correlation, and results of treatment[J]. Cancer, 1970, 26(2): 368-388.
[8] Katabi N, Ghossein R, Ali S, et al.Prognostic features in mucoepidermoid carcinoma of major salivary glands with emphasis on tumour histologic grading[J]. Histopathology, 2014, 65(6): 793-804.
[9] Nordkvist A, Gustafsson H, Juberg-Ode M, et al.Recurrent rearrangements of 11q14-22 in mucoepidermoid carcinoma[J]. Cancer Genet Cytogenet, 1994, 74(2): 77-83.
[10] Tonon G, Modi S, Wu L, et al.t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway[J]. Nat Genet, 2003, 33(2): 208-213.
[11] Enlund F, Behboudi A, Andren Y, et al.Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors[J]. Exp Cell Res, 2004, 292(1): 21-28.
[12] Saade RE, Bell D, Garcia J, et al.Role of CRTC1/MAML2 translocation in the prognosis and clinical outcomes of mucoepidermoid carcinoma[J]. JAMA Otolaryngol Head Neck Surg, 2016, 142(3): 234-240.
[13] Chen Z, Chen J, Gu Y, et al.Aberrantly activated AREG-EGFR signaling is required for the growth and survival of CRTC1-MAML2 fusion-positive mucoepidermoid carcinoma cells[J]. Oncogene, 2014, 33(29): 3869-3877.
[14] Anzick SL, Chen WD, Park Y, et al.Unfavorable prognosis of CRTC1-MAML2 positive mucoepidermoid tumors with CDKN2A deletions[J]. Genes Chromosomes Cancer, 2010, 49(1): 59-69.
[15] Fehr A, Meyer A, Heidorn K, et al.A link between the expression of the stem cell marker HMGA2, grading, and the fusion CRTC1-MAML2 in mucoepidermoid carcinoma[J]. Genes Chromosomes Cancer, 2009, 48(9): 777-785.
[16] Okumura Y, Miyabe S, Nakayama T, et al.Impact of CRTC1/3-MAML2 fusions on histological classification and prognosis of mucoepidermoid carcinoma[J]. Histopathology, 2011, 59(1): 90-97.
[17] Seethala RR, Dacic S, Cieply K, et al.A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas[J]. Am J Surg Pathol, 2010, 34(8): 1106-1121.
[18] Fonseca FP, Sena Filho M, Altemani A, et al.Molecular signature of salivary gland tumors: potential use as diagnostic and prognostic marker[J]. J Oral Pathol Med, 2016, 45(2): 101-110.
[19] Fehr A, Roser K, Heidorn K, et al.A new type of MAML2 fusion in mucoepidermoid carcinoma[J]. Genes Chromosomes Cancer, 2008, 47(3): 203-206.
[20] Nakayama T, Miyabe S, Okabe M, et al.Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma[J]. Mod Pathol, 2009, 22(12): 1575-1581.
[21] Behboudi A, Enlund F, Winnes M, et al.Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene[J]. Genes Chromosomes Cancer, 2006, 45(5): 470-481.
[22] Rotellini M, Paglierani M, Pepi M, et al.MAML2 rearrangement in Warthin's tumour: a fluorescent in situ hybridisation study of metaplastic variants[J]. J Oral Pathol Med, 2012, 41(8): 615-620.
[23] Fehr A, Roser K, Belge G, et al.A closer look at Warthin tumors and the t(11;19)[J]. Cancer Genet Cytogenet, 2008, 180(2): 135-139.
[24] Ishibashi K, Ito Y, Masaki A, et al.Warthin-like mucoepidermoid carcinoma: a combined study of fluorescence in situ hybridization and whole-slide imaging[J]. Am J Surg Pathol, 2015, 39(11): 1479-1487.
[25] Stenman G.Fusion oncogenes in salivary gland tumors: molecular and clinical consequences[J]. Head Neck Pathol, 2013, 7(Suppl 1):S12-S19.
[26] Moller E, Stenman G, Mandahl N, et al.POU5F1, encoding a key regulator of stem cell pluripotency, is fused to EWSR1 in hidradenoma of the skin and mucoepidermoid carcinoma of the salivary glands[J]. J Pathol, 2008, 215(1): 78-86.
[27] Kim S, Lim B, Kim J.EWS-Oct-4B, an alternative EWS-Oct-4 fusion gene, is a potent oncogene linked to human epithelial tumours[J]. Br J Cancer, 2010, 102(2): 436-446.
[28] Shiratsuchi H, Nakashima T, Hirakawa N, et al.beta-Catenin nuclear accumulation in head and neck mucoepidermoid carcinoma: its role in cyclin D1 overexpression and tumor progression[J]. Head Neck, 2007, 29(6): 577-584.
[29] Guo XL, Sun SZ, Wang WX, et al.Alterations of p16INK4a tumour suppressor gene in mucoepidermoid carcinoma of the salivary glands[J]. Int J Oral Maxillofac Surg, 2007, 36(4): 350-353.
[30] Ettl T, Stiegler C, Zeitler K, et al.EGFR, HER2, survivin, and loss of pSTAT3 characterize high-grade malignancy in salivary gland cancer with impact on prognosis[J]. Hum Pathol, 2012, 43(6): 921-931.
[31] Nakano T, Yamamoto H, Hashimoto K, et al.HER2 and EGFR gene copy number alterations are predominant in high-grade salivary mucoepidermoid carcinoma irrespective of MAML2 fusion status[J]. Histopathology, 2013, 63(3): 378-392.
[32] Ou Yang KX, Liang J, Huang ZQ.Association of clinicopathologic parameters with the expression of inducible nitric oxide synthase and vascular endothelial growth factor in mucoepidermoid carcinoma[J]. Oral Dis, 2011, 17(6): 590-596.
[33] Demasi APD, Silva CAB, Silva AD, et al.Expression of the vascular endothelial growth factor and angiopoietins in mucoepidermoid carcinoma of salivary gland[J]. Head Neck Pathol, 2011, 6(1): 10-15.
[34] Skalova A, Lehtonen H, von Boguslawsky K, et al. Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections[J]. Human Pathol, 1994, 25(9): 929-935.
[35] Kiyoshima T, Shima K, Kobayashi I, et al.Expression of p53 tumor suppressor gene in adenoid cystic and mucoepidermoid carcinomas of the salivary glands[J]. Oral Oncol, 2001, 37(3): 315-322.

唾液腺黏液表皮样癌预后评估的组织病理学与分子病理指标

Histopathological and molecular markers in prognostic evaluation of salivary mucoepidermoid carcinoma

可视化

被引次数

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	惠琪, 高万鹏, 李欢, 赵琦, 王珺, 魏建华, 杨新杰, 杨子桧. 唾液腺腺样囊性癌微环境中肿瘤相关巨噬细胞外泌体差异表达miRNAs的筛选及验证[J]. 中国口腔颌面外科杂志, 2024, 22(3): 209-215.
[2]	王敏, 钱佳骏, 薛俊青, 顾挺, 胡宇华, 陈颖, 夏荣辉. 唾液腺腺泡细胞癌中NR4A3基因重排及NOR-1蛋白表达分析[J]. 中国口腔颌面外科杂志, 2024, 22(3): 249-254.
[3]	鲁煜, 刘清海, 梁海胜, 邓刚. 3D-ASL对舌肿物的诊断价值及与病理学特征的相关性分析[J]. 中国口腔颌面外科杂志, 2024, 22(1): 42-48.
[4]	王守鹏, 李胜男, 陈霖, 葛良玉, 李梦, 孟箭. ¹²⁵I放射性粒子植入治疗复发性腭部小唾液腺恶性肿瘤7例临床分析[J]. 中国口腔颌面外科杂志, 2023, 21(5): 497-501.
[5]	韩林孜, 房义康, 禹雯怡, 王奇民, 童磊, 邱建忠, 袁荣涛. 口腔乳头状唾液腺瘤1例临床病理分析[J]. 中国口腔颌面外科杂志, 2022, 20(1): 98-100.
[6]	高倩倩, 尚伟, 刘晓华. 颊部小唾液腺黏液囊肿误诊1例报告[J]. 中国口腔颌面外科杂志, 2021, 19(1): 91-93.
[7]	张卓宇, 撒国良, 魏泽全, 杨学文. 唾液腺:新型冠状病毒的“蓄水池”和“受累者”[J]. 中国口腔颌面外科杂志, 2020, 18(6): 486-489.
[8]	王少如, 高健刚, 徐竹青, 陈正岗, 郑建金, 邱建忠, 袁荣涛, 周建华. 精囊内镜用于诊断和治疗11例阻塞性唾液腺疾病的效果评价[J]. 中国口腔颌面外科杂志, 2020, 18(6): 544-547.
[9]	沈逸超, 俞创奇, 王知俊, 张蔚蒨. 超声弹性成像在唾液腺非肿瘤疾病中的应用进展[J]. 中国口腔颌面外科杂志, 2020, 18(2): 177-181.
[10]	汪洋, 夏亮, 胡宇华, 张春叶, 王丽珍, 李江, 田臻. 基于RNA-Seq分析挖掘唾液腺多形性腺瘤核心基因及通路[J]. 中国口腔颌面外科杂志, 2019, 17(5): 397-402.
[11]	徐万林, 朱云, 卢浩, 刘丽敏, 沈淑坤, 刘胜文, 杨雯君. 15例下颌下腺复发性多形性腺瘤临床病理分析[J]. 中国口腔颌面外科杂志, 2019, 17(5): 465-468.
[12]	徐博雅, 杨子桧, 王珺, 雷德林, 杨新杰. CCL2和CCR2在唾液腺腺样囊性癌中的表达及意义[J]. 中国口腔颌面外科杂志, 2019, 17(4): 311-315.
[13]	王知俊，张蔚蒨，郑凌艳，曹宁宁，石欢，谢李松，俞创奇. 超声弹性成像技术在IgG4相关唾液腺炎诊断和随访中的应用[J]. 中国口腔颌面外科杂志, 2019, 17(3): 225-229.
[14]	傅锦业, 吴春晓, 沈淑坤, 郑莹, 张陈平, 张志愿. 2002—2013年上海市唾液腺恶性肿瘤流行情况分析[J]. 中国口腔颌面外科杂志, 2019, 17(2): 134-140.
[15]	夏亮, 汪洋, 胡宇华, 王丽珍, 顾挺, 李江, 田臻. HER2基因在唾液腺恶性多形性腺瘤细胞增殖、周期、凋亡中的作用[J]. 中国口腔颌面外科杂志, 2018, 16(4): 310-316.