2002—2013年上海市唾液腺恶性肿瘤流行情况分析

doi:10.19438/j.cjoms.2019.02.007

中国口腔颌面外科杂志 ›› 2019, Vol. 17 ›› Issue (2): 134-140.doi: 10.19438/j.cjoms.2019.02.007

2002—2013年上海市唾液腺恶性肿瘤流行情况分析

傅锦业^1,*, 吴春晓^2,*, 沈淑坤¹, 郑莹², 张陈平^1#, 张志愿^1#

1.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科, 国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011;
2.上海市疾病预防控制中心慢性非传染病与伤害防治所肿瘤防治科,上海 200336

收稿日期:2018-10-12 修回日期:2018-12-20 出版日期:2019-03-20 发布日期:2019-04-12
通讯作者: 张陈平,E-mail: zhang.chenping@hotmail.com;张志愿,E-mail: zhzhy639@163.com。^#共同通信作者
作者简介:傅锦业（1973-）,女,博士,主治医师,E-mail: fjy0712@hotmail.com;吴春晓（1981-）,男,硕士,主管医师,E-mail: wuchunxiao@scdc.sh.cn。^*并列第一作者
基金资助:
促进市级医院临床技能与临床创新能力三年行动计划项目（16CR2004A）

Salivary gland carcinoma in Shanghai from 2002 to 2013: an epidemiological study

FU Jin-ye¹, WU Chun-xiao², SHEN Shu-kun¹, ZHENG Ying², ZHANG Chen-ping¹, ZHANG Zhi-yuan¹

1.Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011;
2.Department of Cancer Control & Prevention, Shanghai Municipal Center for Disease Control & Prevention. Shanghai 200336, China

Received:2018-10-12 Revised:2018-12-20 Online:2019-03-20 Published:2019-04-12

摘要/Abstract

摘要： 目的:分析上海市2002—2013年唾液腺恶性肿瘤的人群发病状况,阐明疾病在本地区的流行病学特点。方法:根据上海市疾病预防控制中心提供的唾液腺恶性肿瘤病例资料,通过数据重新核实,采用SPSS 17.0软件包统计唾液腺恶性肿瘤的发病率、性别比、年龄分布状况、解剖部位占比以及病理分布情况;采用年均变化百分比、 χ²检验和Fisher精确检验,比较年度之间的变化情况。结果:2002—2013年,上海市共诊断唾液腺恶性肿瘤新发病例2 308例,发病粗率为13.93/100万,标率为8.54/100万,性别比为1.08∶1;中位首诊年龄为58岁。12年间,发病率变化平稳。唾液腺恶性肿瘤中,1/3来自小唾液腺,其中1/3来自腭腺;大唾液腺的发病比为12∶3∶1。黏液表皮样癌、腺样囊性癌和非特异性腺癌是最常见的3大病理类型。结论:目前上海市唾液腺恶性肿瘤的发病率较低,但不同部位、不同病理类型的好发人群差异较大,提示发病危险因素存在差异,值得关注。

关键词: 唾液腺, 恶性肿瘤, 发病率, 流行病学, 人口学特征, 上海市

Abstract: PURPOSE: To analyze the incidence of salivary gland carcinoma in Shanghai from 2002 to 2013; And to clarify its epidemiological features. METHODS: The incidence data was retrieved from Shanghai Municipal Center for Disease Control & Prevention and re-checked before analysis. SPSS 17.0 software package was used to calculate the incidence rate, male/female ratio, age distribution, percentage of anatomic sites and demographic features of pathology. Comparisons of annual change were performed by annual percent change, Chi-square test and Fisher's exact test. RESULTS: A total of 2 308 cases were newly diagnosed of salivary gland carcinoma from 2002 to 2013 in Shanghai. The crude incidence rate was 13.93 per 1 000 000 and the age-adjusted incidence was 8.54 per 1 000 000. The male to female ratio was 1.08 with median age of 58 years old. The annual incidence was stable during the study period. Among the total cases, one third occurred in minor salivary gland with palate being the most common origin. Carcinoma from major salivary gland confirmed the 12∶3∶1 distribution. Mucoepidermoid, adenoid cystic carcinoma and adenocarcinoma NOS were the top three pathological types. CONCLUSIONS: The incidence of salivary gland carcinoma was relatively low in Shanghai. However, the demography of different pathologic types or anatomic sites varied widely, indicating different risk factors for these cancers which deserves more attention.

Key words: Salivary gland, Carcinoma, Incidence, Epidemiology, Demography, Shanghai

中图分类号:

R739.8

傅锦业, 吴春晓, 沈淑坤, 郑莹, 张陈平, 张志愿. 2002—2013年上海市唾液腺恶性肿瘤流行情况分析[J]. 中国口腔颌面外科杂志, 2019, 17(2): 134-140.

FU Jin-ye, WU Chun-xiao, SHEN Shu-kun, ZHENG Ying, ZHANG Chen-ping, ZHANG Zhi-yuan. Salivary gland carcinoma in Shanghai from 2002 to 2013: an epidemiological study[J]. China J Oral Maxillofac Surg, 2019, 17(2): 134-140.

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2002—2013年上海市唾液腺恶性肿瘤流行情况分析

Salivary gland carcinoma in Shanghai from 2002 to 2013: an epidemiological study

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