唾液腺:新型冠状病毒的“蓄水池”和“受累者”

doi:10.19438/j.cjoms.2020.06.003

中国口腔颌面外科杂志 ›› 2020, Vol. 18 ›› Issue (6): 486-489.doi: 10.19438/j.cjoms.2020.06.003

• 全民健康助力全面小康专栏 • 上一篇下一篇

唾液腺:新型冠状病毒的“蓄水池”和“受累者”

张卓宇, 撒国良, 魏泽全, 杨学文

武汉大学口腔医学院正颌与唇腭裂整形外科,口腔基础医学省部共建国家重点实验室培育基地和口腔生物医学教育部重点实验室,武汉大学口腔医学院,湖北武汉 430079

收稿日期:2020-07-06 修回日期:2020-08-25 发布日期:2020-12-31
通讯作者: 杨学文,E-mail:yxw._1962@whu.edu.cn
作者简介:张卓宇(1995-),女,在读硕士研究生,E-mail:zzhuozhuo13579@126.com
基金资助:
武汉大学教学研究项目(2019-YB-7)

Salivary glands: reservoir and victim of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)

ZHANG Zhuo-yu, SA Guo-liang, WEI Ze-quan, YANG Xue-wen

Department of Orthognathic & Cleft Lip and Palate Plastic Surgery, School of Stomatology Wuhan University; The State Key Laboratory Breeding Base of Basic Science of StomatologyHubei-MOST & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University. Wuhan 430079, Hubei Province, China

Received:2020-07-06 Revised:2020-08-25 Published:2020-12-31

摘要/Abstract

摘要： 新型冠状病毒引发的肺炎(简称新冠肺炎,coronavirus disease 2019,COVID-19)已在全球蔓延并快速进展,对人类的健康、经济活动和生活方式造成了巨大影响。口腔诊疗操作依赖牙科涡轮机,产生大量气溶胶,使口腔医护人员暴露于高风险环境中。唾液腺是唾液的来源,其是否感染新型冠状病毒和口腔诊疗风险密切相关。本文搜集国内外已发表的相关文献,总结新冠病毒对唾液腺感染及其在唾液腺内的复制过程和对唾液腺功能影响等方面的最新信息,旨在为口腔医护人员在疫情暴发及常态化防控期间的防护提供帮助。

关键词: 新型冠状病毒, 新型冠状病毒肺炎, 唾液腺, 唾液

Abstract: Coronavirus disease 2019(COVID-19) has spread globally and is progressing rapidly, which has a huge impact on human health, economic activities and life styles. Oral and dental care, which produces a lot of aerosols due to the usage of dental turbine, is a high-risk medical field. Whether salivary glands can be infected by SARS-CoV-2 is positively linked with the risks that the dentists confront, as salivary glands are the resources of saliva. This review summarized the literature on SARS-CoV-2 infection and impact of salivary glands, as well as their replication in salivary glands, so as to protect dentists during COVID-19 outbreak.

Key words: SARS-CoV-2, COVID-19, Salivary glands, Saliva

中图分类号:

R782

张卓宇, 撒国良, 魏泽全, 杨学文. 唾液腺:新型冠状病毒的“蓄水池”和“受累者”[J]. 中国口腔颌面外科杂志, 2020, 18(6): 486-489.

ZHANG Zhuo-yu, SA Guo-liang, WEI Ze-quan, YANG Xue-wen. Salivary glands: reservoir and victim of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)[J]. China J Oral Maxillofac Surg, 2020, 18(6): 486-489.

参考文献

[1] Wang C, Horby PW, Hayden FG, et al.A novel coronavirus outbreak of global health concern[J]. Lancet, 2020, 395(10223): 470-473.
[2] Khurshid Z, Asiri FYI, Al Wadaani H.Human saliva: non-invasive fluid for detecting novel coronavirus (2019-nCoV)[J]. Int J Environ Res Public Health, 2020, 17(7): 2225-2225.
[3] 李建辉,麻婧,康文,等.新型冠状病毒2019-nCoV的病毒学特征、传播途径及抵抗力[J].临床医学研究与实践,2020,5(S1):3-5.
[4] Peng X, Xu X, Li Y, et al.Transmission routes of 2019-nCoV and controls in dental practice[J]. Int J Oral Sci, 2020, 12(1): 9-14.
[5] Lo Giudice R.The severe acute respiratory syndrome coronavirus-2 (SARS CoV-2) in dentistry. Management of biological risk in dental practice[J]. Int J Environ Res Public Health, 2020, 17(9): 3067-3077.
[6] Henrique Braz-Silva P, Pallos D, Giannecchini S, et al. SARS-CoV-2: what can saliva tell us? [J]. Oral Dis, 2020 Apr 20. [Online ahead of print].
[7] 白亮,刘宝宁,赵四海,等.新型冠状病毒来源、传播途径及易感动物模型研究进展[J].临床医学研究与实践, 2020, 5(S1): 1-2,11.
[8] Xu R, Cui B, Duan X, et al.Saliva: potential diagnostic value and transmission of 2019-nCoV[J]. Int J Oral Sci, 2020, 12(2): 11.
[9] Yoon JG, Yoon J, Song JY, et al.Clinical significance of a high SARS-CoV-2 viral load in the saliva[J]. J Korean Med Sci, 2020, 35(20): e195-e201.
[10] Yang JR, Deng DT, Wu N, et al.Persistent viral RNA positivity during the recovery period of a patient with SARS-CoV-2 infection[J]. J Med Virol, 2020, 92(9): 1681-1683.
[11] Azzi L, Carcano G, Dalla Gasperina D, et al. Two cases of COVID-19 with positive salivary and negative pharyngeal or respiratory swabs at hospital discharge: a rising concern[J]. Oral Dis, 2020 Apr 15. [Online ahead of print].
[12] Zheng S, Fan J, Yu F, et al.Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang Province, China, January-March 2020: retrospective cohort study[J]. BMJ, 2020, 369: m1443-m1451.
[13] To KK, Tsang OT, Yip CC, et al.Consistent detection of 2019 novel coronavirus in saliva[J]. Clin Infect Dis, 2020, 71(15): 841-843.
[14] Chen L, Zhao J, Peng J, et al. Detection of2019-nCoV in saliva and characterization of oral symptoms in COVID-19 patients[DB/OL]. https://ssrn.com/abstract=3557140.
[15] Xu J, Li Y, Gan F, et al.Salivary glands: potential reservoirs for covid-19 asymptomatic infection[J]. J Dent Res, 2020, 99(8): 989-989.
[16] Song J, Li Y, Huang X, et al. Systematic analysis of ACE2 and TMPRSS2 expression in salivary glands reveals underlying transmission mechanism caused by SARS-CoV-2[J]. J Med Virol, 2020 May 22. [Online ahead of print].
[17] Liu L, Wei Q, Alvarez X, et al.Epithelial cells lining salivary gland ducts are early target cells of severe acute respiratory syndrome coronavirus infection in the upper respiratory tracts of rhesus macaques[J]. J Virol, 2011,85(8): 4025-4030.
[18] Guerini-Rocco E, Taormina SV, Vacirca D, et al.SARS-CoV-2 detection in formalin-fixed paraffin-embedded tissue specimens from surgical resection of tongue squamous cell carcinoma[J]. J Clin Pathol, 2020, 73(11): 754-757.
[19] Kannan S, Shaik Syed Ali P, Sheeza A, et al. COVID-19 (Novel Coronavirus 2019) - recent trends[J]. Eur Rev Med Pharmacol Sci, 2020,24(4): 2006-2011.
[20] Zhou P, Yang XL, Wang XG, et al.A pneumonia outbreak associated with a new coronavirus of probable bat origin[J]. Nature, 2020,579(7798): 270-273.
[21] Irigoyen N, Firth AE, Jones JD, et al.High-resolution analysis of coronavirus gene expression by RNA sequencing and ribosome profiling[J]. PLoS Pathog, 2016,12(2): e1005473.
[22] Gomez GN, Abrar F, Dodhia MP, et al.SARS coronavirus protein nsp1 disrupts localization of Nup93 from the nuclear pore complex[J]. Biochem Cell Biol, 2019, 97(6): 758-766.
[23] Peiris JS, Chu CM, Cheng VC, et al.Clinical progression and viral load in a com- munity outbreak of coronavirus-associated SARS pneumonia: a prospective study[J]. Lancet, 2003, 361(9371): 1767-1772.
[24] Capaccio P, Pignataro L, Corbellino M, et al.Acute parotitis: a possible precocious clinical manifestation of SARS-CoV-2 infection?[J]. Otolaryngol Head Neck Surg, 2020,163(1): 182-183.
[25] Wang C, Wu H, Ding X, et al.Does infection of 2019 novel coronavirus cause acute and/or chronic sialadenitis?[J]. Med Hypotheses, 2020, 140: 109789.
[26] Farshidfar N, Hamedani S. Hyposalivation as a potential risk for SARS-CoV-2 infection: Inhibitory role of saliva[J]. Oral Dis, 2020 Apr 29. [Online ahead of print].
[27] Antoniades D, Harrison JD, Epivatianos A, et al.Treatment of chronic sialadenitis by intraductal penicillin or saline[J]. J Oral Maxillofac Surg, 2004, 62(4): 431-434.
[28] Harrison JD, Epivatianos A.Production of microliths and sialaden it is in rats by a short combined course of isoprenaline and calcium gluconate[J]. Oral Surg Oral Med Oral Pathol, 1992, 73(5): 585-590.
[29] 张艳霞, 刘雯, 孔亮, 等. 新型冠状病毒肺炎疫情期口腔医院防护标准(一)—工作人员防护[J].实用口腔医学杂志, 2020, 36(2): 157-161.
[30] 王林虎,林海燕,董青山,等.口腔医务人员职业防护现状与新冠肺炎疫情下的对策[J].临床口腔医学杂志,2020,36(4): 238-241.
[31] Zimmermann M, Nkenke E.Approaches to the management of patients in oral and maxillofacial surgery during COVID-19 pandemic[J]. J Craniomaxillofac Surg, 2020, 48(5): 521-526.
[32] 中华口腔医学会口腔颌面外科专业委员会.口腔颌面外科手术在新型冠状病毒感染流行期管理的专家意见[J].中国口腔颌面外科杂志,2020,18(2): 97-99.
[33] Jamal M, Shah M, Almarzooqi SH, et al. Overview of transnational recommendations for COVID-19 transmission control in dental care settings[J]. Oral Dis, 2020 May 19 [Online ahead of print].

唾液腺:新型冠状病毒的“蓄水池”和“受累者”

Salivary glands: reservoir and victim of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)

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