口腔疣状癌临床诊治专家共识

doi:10.19438/j.cjoms.2018.04.014

中国口腔颌面外科杂志 ›› 2018, Vol. 16 ›› Issue (4): 362-370.doi: 10.19438/j.cjoms.2018.04.014

口腔疣状癌临床诊治专家共识

唐瞻贵^1#, 步荣发², 刘彦普³, 郭伟⁴, 孙沫逸³, 郑家伟⁴, 何悦⁴, 尚政军⁵, 吴煜农⁶, 李劲松⁷, 韩正学⁸, 田臻⁹, 张陈平⁴, 李铁军¹⁰, 钟鸣¹¹, 廖贵清¹², 沈子华¹, 黄俊辉¹³, 喻建军¹⁴, 苏彤¹⁵, 姚志刚¹³, 胡延佳¹

1.中南大学湘雅口腔医（学）院口腔颌面外科,湖南长沙 410013;
2.中国人民解放军总医院口腔颌面外科,北京 100853;
3.空军军医大学（第四军医大学）口腔医学院口腔颌面外科,陕西西安 710032;
4.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科, 上海 200011;
5.武汉大学口腔医学院口腔颌面外科,湖北武汉 430072;
6.南京医科大学附属口腔医院（江苏省口腔医院）口腔颌面外科,江苏南京 210029;
7.中山大学孙逸仙纪念医院口腔颌面外科,广东广州 510120;
8.首都医科大学附属北京口腔医院口腔颌面外科,北京 100050;
9.上海交通大学医学院附属第九人民医院·口腔医学院口腔病理科,上海 200011;
10.北京大学口腔医学院口腔病理科,北京 100081;
11.中国医科大学口腔医学院口腔病理科,辽宁沈阳 110122;
12.广州中山大学附属口腔医院口腔颌面外科,广东广州 510055;
13.中南大学湘雅口腔医（学）院口腔病理科,湖南长沙 410013;
14.湖南省肿瘤医院头颈外科,湖南长沙 410006;
15.中南大学湘雅医院口腔颌面外科,湖南长沙 410008

收稿日期:2018-03-09 修回日期:2018-03-28 出版日期:2018-07-20 发布日期:2018-08-09
通讯作者: 唐瞻贵,E-mail: tangzhangui@aliyun.com
作者简介:唐瞻贵（1964-）,男,博士,教授,主任医师,博士研究生导师
基金资助:
国家自然科学基金（81671003）; 湖南省科技计划（2014SK4006）

Expert consensus statement on diagnosis and clinical management of oral verrucous carcinoma

TANG Zhan-gui¹, BU Rong-fa², LIU Yan-pu³, GUO Wei⁴, SUN Mo-yi³, ZHENG Jia-wei⁴, HE Yue⁴, SHANG Zheng-jun⁵, WU Yu-nong⁶, LI Jin-song⁷, HAN Zheng-xue⁸, TIAN Zhen⁹, ZHANG Chen-ping⁴, LI Tie-jun¹⁰, ZHONG Ming¹¹, LIAO Gui-qing¹², SHEN Zi-hua¹, HUANG Jun-hui¹³, YU Jian-jun¹⁴, SU Tong¹⁵, YAO Zhi-gang¹³, HU Yan-jia¹

1.Department of Oral and Maxillofacial Surgery, Xiangya School of Stomatology, Central South University. Changsha 410013, Hunan Province;
2.Department of Oral and Maxillofacial Surgery, China PLA General Hospital. Beijing 100853;
3.Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University. Xi'an 710032, Shaanxi Province;
4. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
5.Department of Oral and Maxillofacial Surgery, School of Stomatology, Wuhan University. Wuhan 430072, Hubei Province;
6. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Nanjing Medical University. Nanjing 210029, Jiangsu Province;
7. Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province;
8. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Capital Medical University. Beijing 100050;
9.Department of Oral Pathology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
10. Department of Oral Pathology, School of Stomatology, Peking University. Beijing 100081;
11. Department of Oral Pathology, School of Stomatology, China Medical University. Shenyang 110122, Liaoning Province;
12. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Sun Yat sen University. Guangzhou 510055, Guangdong Province;
13. Department of Oral Pathology, Xiangya School of Stomatology, Central South University. Changsha 410013, Hunan Province;
14. Department of Head and Neck Surgery, Hunan Provincial Tumor Hospital. Changsha 410006, Hunan Province;
15. Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University. Changsha 410008, Hunan Province, China

Received:2018-03-09 Revised:2018-03-28 Online:2018-07-20 Published:2018-08-09

摘要/Abstract

摘要： 口腔疣状癌(oral verrucous carcinoma, OVC)是一种具有独特组织学改变和生物学行为,有别于口腔鳞状细胞癌(oral squamous cell carcinoma, OSCC)的恶性肿瘤,发病原因目前尚不明确。研究发现,其首次临床诊断符合率仅为35%,常被误诊为疣状增生、牙源性角化囊肿、侵袭性牙周炎和慢性颌骨骨髓炎等疾病。OVC的治疗手段和预后与OSCC不尽相同,误诊和误治严重影响患者的生存质量。制定OVC临床诊治专家共识的目的,是希望减少OVC误诊误治,提高早期诊断率、患者生存率和生活质量。

关键词: 口腔疣状癌, 临床诊治, 专家共识

Abstract: Oral verrucous carcinoma (OVC) is a malignant tumor with independent histological changes and biological behaviors different from those of oral squamous cell carcinomas (OSCC). Its etiology is still unclear. It has the first clinical diagnosis coincidence rate of only 35% and is often misdiagnosed as other oral diseases such as verrucous hyperplasia, odontogenic keratocyst, aggressive periodontitis and chronic osteomyelitis. The treatment and prognosis of OVC are different from those of OSCC. Its misdiagnosis and mistreatment seriously affect patients' quality of life. In order to reduce misdiagnosis and mistreatment of OVC and to improve its early diagnostic rate, patients' survival rate and quality of life, it is necessary to establish an expert consensus on this tumor according to the national clinical conditions.

Key words: Oral verrucous carcinoma, OVC, Clinical diagnosis and management, Expert consensus

中图分类号:

R739.8

唐瞻贵, 步荣发, 刘彦普, 郭伟, 孙沫逸, 郑家伟, 何悦, 尚政军, 吴煜农, 李劲松, 韩正学, 田臻, 张陈平, 李铁军, 钟鸣, 廖贵清, 沈子华, 黄俊辉, 喻建军, 苏彤, 姚志刚, 胡延佳. 口腔疣状癌临床诊治专家共识[J]. 中国口腔颌面外科杂志, 2018, 16(4): 362-370.

TANG Zhan-gui, BU Rong-fa, LIU Yan-pu, GUO Wei, SUN Mo-yi, ZHENG Jia-wei, HE Yue, SHANG Zheng-jun, WU Yu-nong, LI Jin-song, HAN Zheng-xue, TIAN Zhen, ZHANG Chen-ping, LI Tie-jun, ZHONG Ming, LIAO Gui-qing, SHEN Zi-hua, HUANG Jun-hui, YU Jian-jun, SU Tong, YAO Zhi-gang, HU Yan-jia. Expert consensus statement on diagnosis and clinical management of oral verrucous carcinoma[J]. China J Oral Maxillofac Surg, 2018, 16(4): 362-370.

参考文献

[1] Stewart BW, Wild CW.World cancer report[M]. Lyon: International Agency for Research on Cancer, 2014.
[2] Rivera C.Essentials of oral cancer[J]. Int J Clin Exp Pathol, 2015, 8(9): 11884-11894.
[3] Pereira MC, Oliveira DT, Kowalski LP, et al.Histologic subtypes of oral squamous cell carcinoma: prognostic relevance[J]. J Can Dent Assoc, 2007, 73(4): 339-344.
[4] Ackerman LV.Verrucous carcinoma of the oral cavity[J]. Surgery, 1948, 23(4): 670-678.
[5] Alonso JE, Han AY, Kuan EC, et al.Epidemiology and survival outcomes of sinonasal verrucous carcinoma in the United States[J]. Laryngoscope, 2018, 128(3): 651-656.
[6] Campaner AB, Cardoso FA, Fernandes GL, et al.Verrucous carcinoma of the vulva: diagnosis and treatment[J]. An Bras Dermatol, 2017, 92(2): 243-245.
[7] 王瑛, 吴奇光, 郑麟蕃. 口腔黏膜疣状癌的临床病理学研究[J]. 中华口腔科杂志, 1985, 20(3): 65-68.
[8] 唐瞻贵, 谢晓莉, 李晋芸, 等. 口腔疣状癌的误诊研究[J]. 临床口腔医学杂志, 2003, 19(8): 474-475.
[9] Kallarakkal TG, Ramanathan A, Zain RB.Verrucous papillary lesions: dilemmas in diagnosis and terminology[J]. Int J Dent, 2013, 2013: 298249.
[10] Alan H, Agacayak S, Kavak G, et al.Verrucous carcinoma and squamous cell papilloma of the oral cavity: Report of two cases and review of literature[J]. Eur J Dent, 2015, 9(3): 453-456.
[11] Garcia NG, Oliveira DT, Hanemann JA, et al.Oral verrucous carcinoma mimicking a chronic candidiasis: a case report[J]. Case Rep Oncol Med, 2012, 2012: 190272.
[12] 唐瞻贵, 谢晓莉, 粟红兵, 等. 口腔黏膜疣状癌电镜观察及其与临床病理的联系[J]. 湖南医科大学学报, 1996, 39(3): 262-264.
[13] Walvekar RR, Chaukar DA, Deshpande MS, et al.Verrucous carcinoma of the oral cavity: A clinical and pathological study of 101 cases[J]. Oral Oncol, 2009, 45(1): 47-51.
[14] Noble-Topham SE, Fliss DM, Hartwick RW, et al.Detection and typing of human papillomavirus in verrucous carcinoma of the oral cavity using the polymerase chain reaction[J]. Arch Otolaryngol Head Neck Surg, 1993, 119(12): 1299-1304.
[15] 邹萍, 唐瞻贵, 冯德云, 等. 人乳头瘤病毒16/18型、p53、p16蛋白在口腔疣状癌中的表达[J]. 口腔颌面外科杂志, 2003, 13(3): 211-215.
[16] 邹萍, 唐瞻贵, 冯德云, 等. 人乳头状瘤病毒16/18型在口腔疣状癌中的表达及意义[J]. 现代口腔医学杂志, 2004, 18(1): 5-8.
[17] De Socio GV, Bidovanets O, Tomassini GM, et al.Human papilloma virus-associated lips verrucous carcinoma in HIV-infected male[J]. J Int Assoc Provid AIDS Care, 2017, 16(4): 324-326.
[18] Gupta S, Kumar K, Raviprakash SM, et al.Ackerman's tumor of the oral cavity: A study of four cases with its conglomerate appearance[J]. J Dent Specialties, 2015, 3(4): 92-95.
[19] Luo JS, Tang ZG, Li L, et al.Verrucous carcinoma associated with oral submucous fibrosis that gradually transforms to squamous cell carcinoma: a rare case report[J]. Int J Clin Exp Pathol, 2016, 9(11): 11838-11842.
[20] Shafer WG.Verrucous carcinoma[J]. Int Dent J, 1972, 22(4): 451-459.
[21] 唐瞻贵, 李晋芸, 苏彤, 等. 口腔疣状癌的临床研究[J]. 口腔颌面外科杂志, 2002, 12(1): 87-88.
[22] Tang ZG, Xie XL, Li JY, et al.A clinical study on oral verrucous carcinoma[J]. Int J Oral Max Surg, 2003, 32(Suppl): 60.
[23] Rodrigues J, Vaz OP, Salelkar RS, et al.A rare case of verrucous carcinoma on the dorsum of the tongue[J]. Int J Adv Case Rep, 2015, 2(8): 530-531.
[24] Tang ZG, Xie XL, Li JY, et al.A clinic study on oral verrucous carcinoma phenotypes[J]. Chin J Dent Res, 2005, 8(3): 57-61.
[25] Peng Q, Tang ZG, Wang YH, et al.Oral verrucous carcinoma: from multifactorial etiology to diverse treatment regimens (Review)[J]. Int J Oncol, 2016, 49(1): 59-73.
[26] Fang XD, Liu OS, Tang ZG.Oral verrucous carcinoma: a retrospective clinical study of 29 Chinese patients[J]. Int J Clin Exp Med, 2017, 10(3): 5228-5232.
[27] Kolokythas A, Rogers TM, Miloro M.Hybrid verrucous squamous carcinoma of the oral cavity: treatment considerations based on a critical review of the literature[J]. J Oral Maxillofac Surg, 2010, 68(9): 2320-2324.
[28] Gokavarapu S, Rao SLM, Tantravahi US, et al.Oral hybrid verrucous carcinoma: a clinical study[J]. Indian J Surg Oncol, 2014, 5(4): 257-262.
[29] Karagozoglu KH, Buter J, Leemans CR, et al.Subset of patients with verrucous carcinoma of the oral cavity who benefit from treatment with methotrexate[J]. Br J Oral Maxillofac Surg, 2012, 50(6): 513-518.
[30] Liu O, Zhang HX, Tang ZG, et al.Stereology study of oral verrucous carcinoma[J]. J BUON, 2012, 17(2): 343-349.
[31] 唐瞻贵, 谢晓莉, 粟红兵, 等. 口腔黏膜疣状癌电镜观察及其临床病理的联系[J]. 湖南医科大学学报, 1996, 21(3): 262-264.
[32] 唐瞻贵, 王月红. 口腔疣状癌研究进展[J]. 中华口腔医学杂志(电子版), 2010, 4(5): 425-432.
[33] Zhu LK, Ding YW, Liu W, et al.A clinicopathological study on verrucous hyperplasia and verrucous carcinoma of the oral mucosa[J]. J Oral Patho Med, 2012, 41(2): 131-135.
[34] Grover S, Jha M, Sharma B, et al.Verrucous Hyperplasia: case report and differential diagnosis[J]. Sultan Qaboos Univ Med J, 2017, 17(1): e98-102.
[35] Paral KM, Taxy JB, Lingen MW.CD34 and α smooth muscle actin distinguish verrucous hyperplasia from verrucous carcinoma[J]. Oral Surg Oral Med Oral Pathol, 2014, 117(4): 477-482.
[36] Habiba U, Kitamura T, Yanagawa MA, et al.Cytoplasmic expression of HuR may be a valuable diagnostic tool for determining the potentialor malignant transformation of oral verrucous borderline lesions[J]. Oncol Rep, 2014, 31(4): 1547-1554.
[37] Oliveira MC, Silveira EJ, Godoy GP, et al.Immunohistochemical evaluation of intermediate filament proteins in squamous papilloma and oral verrucous carcinoma[J]. Oral Dis, 2005, 11(5): 288-292.
[38] Dalirsani Z, Falaki F, Mohtasham N, et al.Oral verrucous carcinoma and ameloblastoma: a rare coincidence[J]. Iran J Otorhinolaryngol, 2015, 27(79): 159-163.
[39] 黄谢山, 谈顺. 口腔颌面疣状癌误诊1例[J]. 口腔医学研究, 2010, 26(1): 107-107.
[40] Verma DK, Bansal S, Gupta D, et al.Neck dissection in verrucous carcinoma: A surgical dilemma[J]. IJSS Case Rep Rev, 2015, 2(1): 42-45.
[41] Sciubba JJ, Helman JI.Current management strategies for verrucous hyperkeratosis and verrucous carcinoma[J]. Oral Maxillofac Surg Clin North Am, 2013, 25(1): 77-82.
[42] Yu CH, Lin HP, Cheng SJ, et al.Cryotherapy for oral precancers and cancers[J]. J Formos Med Assoc, 2014, 113(5): 272-277.
[43] Yeh CJ.Treatment of verrucous hyperplasia and verrucous carcinoma by shave excision and simple cryosurgery[J]. Int J Oral Maxillofac Surg, 2003, 32(3): 280-283.
[44] Galimberti D, Galimberti G, Pontón Montaño A, et al.Oral verrucous carcinoma treated with carbon dioxide laser[J]. J Eur Acad Dermatol Venereol, 2010, 24(8): 976-977.
[45] Azevedo LH, Galletta VC, de Paula Eduardo C, et al. Treatment of oral verrucous carcinoma with carbon dioxide laser[J]. J Oral Maxillofac Surg, 2007, 65(11): 2361-2366.
[46] Kwon HB, Choi YS, Lee JH, et al.Treatment of verrucous carcinoma of the lower lip with topical imiquimod (Aldara) and debulking therapy[J]. Ann Dermatol, 2011, 23(Suppl 1): S68-71.
[47] Sadasivan A, Thankappan K, Rajapurkar M, et al.Verrucous lesions of the oral cavity treated with surgery: Analysis of clinico-pathologic features and outcome[J]. Contemp Clin Dent, 2012, 3(1): 60-63.
[48] Candau-Alvarez A, Dean-Ferrer A, Alamillos-Granados FJ, et al.Verrucous carcinoma of the oral mucosa: an epidemiological and follow-up study of patients treated with surgery in 5 last years[J]. Med Oral Patol Oral Cir Bucal, 2014, 19(5): e506-e511.
[49] Vidyasagar MS, Fernandes DJ, Kasturi DP, et al.Radiotherapy and verrucous carcinoma of the oral cavity. A study of 107 cases[J]. Acta Oncol, 1992, 31(1): 43-47.
[50] van Gestel KM, Buurman DJ, Pijls R, et al. Locally advanced verrucous carcinoma of the oral cavity: Treatment using customized mold HDR brachytherapy instead of hemi-maxillectomy[J]. Strahlenther Onkol, 2013, 189(10): 894-898.
[51] Wu CF, Chen CM, Shen YS, et al.Effective eradication of oral verrucous carcinoma with continuous intraarterial infusion chemotherapy[J]. Head Neck, 2008, 30(5): 611-617.
[52] Salesiotis A, Soong R, Diasio RB, et al.Capecitabine induces rapid, sustained response in two patients with extensive oral verrucous carcinoma[J]. Clin Cancer Res, 2003, 9(2): 580-585.
[53] Deng ZY, Wang YH, Tang ZG, et al.Investigation of the association between miR-181b, Bcl-2 and LRIG1 in oral verrucous carcinoma[J]. Mol Med Rep, 2016, 14(4): 2991-2996.
[54] Wang YH, Tian X, Tang ZG, et al.Gene profiling analysis for patients with oral verrucous carcinoma and oral squamous cell

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[11]	中华口腔医学会牙及牙槽外科专业委员会. 自体牙移植术规范化操作流程中国专家共识[J]. 中国口腔颌面外科杂志, 2020, 18(5): 390-394.
[12]	鞠侯雨, 郑家伟, 孙沫逸, 唐瞻贵, 杨道科, 冉炜, 步荣发, 尚伟, 孟箭, 武和明, 席庆, 杨凯, 王军, 邹建明, 吴云腾, 任国欣, 郭伟. 口腔颌面头颈部鳞癌超声热化疗中国专家共识[J]. 中国口腔颌面外科杂志, 2020, 18(3): 193-198.
[13]	唐瞻贵, 步荣发, 郭伟, 孙沫逸, 郑家伟, 彭歆, 张惠, 段小红, 姜虹, 王淼, 张铁军, 杨旭东, 杨凯, 喻建军, 罗志勇, 谢咏秋, 胡延佳, 王柏胜. 口腔医疗中恶性高热临床诊治中国专家共识[J]. 中国口腔颌面外科杂志, 2020, 18(1): 1-9.
[14]	蒋灿华, 翦新春, 张志愿, 郑家伟, 石冰, 刘彦普, 何悦, 彭歆, 尚政军, 韩新光, 刘蔚东, 莫洋, 郭峰, 程智刚, 陈传俊, 龚忠诚, 金武龙, 张世周, 袁荣涛, 严奉国, 李鹏程, 张胜, 高兴, 陈洁. 口腔颌面外科日间手术中国专家共识[J]. 中国口腔颌面外科杂志, 2019, 17(5): 385-390.
[15]	刘建华, 张志愿, 石冰, 郭传瑸, 孙坚, 王慧明, 孙长伏, 郑谦. 唇缺损局部组织瓣修复重建专家共识[J]. 中国口腔颌面外科杂志, 2019, 17(5): 391-396.

口腔疣状癌临床诊治专家共识

Expert consensus statement on diagnosis and clinical management of oral verrucous carcinoma

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