Predictive value of preoperative neutrophil to platelet ratio in the diagnosis of parotid malignant tumors

doi:10.19438/j.cjoms.2026.01.004

Abstract

Abstract: PURPOSE: To explore the diagnostic value of preoperative neutrophil-to-platelet ratio(NPR) in malignant parotid tumors, and to analyze its correlation with tumor stage and lymph node metastasis. METHODS: A total of 248 patients with parotid tumors admitted to Affiliated Hospital of Xuzhou Medical University from October 2022 to October 2024 were selected, including 124 cases in the malignant tumor group (experimental group) and 124 cases in the benign tumor group (control group). Inflammatory indicators such as preoperative peripheral blood NPR, neutrophil-to-lymphocyte ratio (NLR), and systemic inflammatory response index (SIRI) were compared between the two groups. Logistic regression analysis was used to screen independent risk factors for malignant parotid tumors, and receiver operating characteristic (ROC) curve was employed to evaluate the diagnostic efficacy of NPR. RESULTS: The level of NPR in the experimental group was significantly higher than that in the control group(P<0.001). Multivariate logistic regression showed that NPR was an independent risk factor for malignant parotid tumors(OR=1.055, 95%CI: 1.007-1.104, P=0.022). In the experimental group, NPR in the lymph node metastasis group was significantly higher than that in the non-metastasis group(P<0.001), and NPR in the advanced stage group(stage Ⅲ + Ⅳ) was significantly higher than that in the early stage group (stage Ⅰ+Ⅱ)(P<0.05). The ROC curve showed that the area under the curve(AUC) of NPR for diagnosing malignant parotid tumors was 0.663(95%CI: 0.587-0.739). At the optimal cut-off value of 0.014, the sensitivity was 68.8% and the specificity was 58.3%. CONCLUSIONS: The level of preoperative peripheral venous blood NPR can be used as an auxiliary diagnostic indicator for malignant parotid tumors. A high NPR indicates a high risk of malignant tumors, advanced stage, and a high possibility of lymph node metastasis. However, its diagnostic efficacy is limited and needs to be comprehensively judged in combination with clinical examination.

Key words: Malignant parotid tumor, Neutrophil-to-platelet ratio, Inflammatory response, Diagnostic value, Lymph node metastasis

CLC Number:

Xue Xingyue, Cao Kun, Lu Fang, Bao Qiang, Sun Yuhua, Li Jiafeng. Predictive value of preoperative neutrophil to platelet ratio in the diagnosis of parotid malignant tumors[J]. China Journal of Oral and Maxillofacial Surgery, 2026, 24(1): 23-27.

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