Research progress of adoptive T cell therapy in head and neck squamous cell carcinoma

doi:10.19438/j.cjoms.2024.02.014

Abstract

Abstract: Adoptive T cell therapy(ACT) is a new adoptive cell immunotherapy, which is developing rapidly in clinical research. Several studies have shown that ACT could enhance the specificity and reactivity of tumor tissue by increasing the number of T cells, thereby overcoming the suppression of tumor immune deficiency. There are three main modes of ACT: tumor infiltrating lymphocytes(TILs), chimeric antigen receptor T cells(CAR-T), and T cell receptor engineered T cells(TCR-T). In this review, we discussed the classification and research progress of various ACT therapies, including TILs, TCR-T, CAR-T and adoptive T cell therapy based on organoid co-culture, and explored the application prospects of ACT as a treatment method for head and neck squamous cell carcinoma.

Key words: Adoptive T cell therapy, Head and neck squamous cell carcinoma, Tumor infiltrating lymphocytes, Chimeric antigen receptor T cells, T cell receptor engineered T cells, Organoid

CLC Number:

R739.8

CHEN Yin-yu, CHEN Lin, XU Feng, ZOU Zi-chuan, GE Liang-yu, MENG Jian. Research progress of adoptive T cell therapy in head and neck squamous cell carcinoma[J]. China Journal of Oral and Maxillofacial Surgery, 2024, 22(2): 192-197.

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