Abstract: PURPOSE: To discuss the clinical features of IgG4-related sclerosing sialadenitis and salivary glands non-neoplastic diseases presenting gland swelling, to make clear the key points of clinical differential diagnosis. METHODS: We retrospectively analyzed and compared the clinical data of IgG4-related sclerosing sialadenitis with those of salivary glands non-neoplastic diseases especially Sjögren’s syndrome (SS) in medical history, clinical examination, serology and pathology. The statistical analysis was performed using SAS 8.0 software package. RESULTS: Three hundred and thirty-five patients with salivary glands non-neoplastic diseases were included in the study, including 25 IgG4-related sclerosing sialadenitis, 279 obstructive sialadenitis and 31 SS. We compared IgG4-related sclerosing sialadenitis with the others and found out significant differences in each aspects. CONCLUSIONS: IgG4-related sclerosing sialadenitis is a kind of chronic salivary gland inflammation with glands swelling. In order to make a definite diagnosis with other salivary glands non-neoplastic diseases, a comprehensive analysis is needed.

Key words: IgG4-related sclerosing sialadenitis, Obstructive sialadenitis, Sjögren’s syndrome