Glut-1和HIF-1α在口腔鳞癌中的表达及与预后的相关性分析

doi:10.19438/j.cjoms.2026.02.001

中国口腔颌面外科杂志 ›› 2026, Vol. 24 ›› Issue (2): 105-109.doi: 10.19438/j.cjoms.2026.02.001

Glut-1和HIF-1α在口腔鳞癌中的表达及与预后的相关性分析

韩生伟, 汤传超, 王玉凤, 韩伟

南京大学医学院附属口腔医院口腔颌面外科,南京市口腔医院, 南京大学口腔医学研究所,江苏南京 210008

收稿日期:2025-04-28 修回日期:2025-05-30 出版日期:2026-03-20 发布日期:2026-04-02
通讯作者: 韩伟,E-mail：doctorhanwei@hotmail.com
作者简介:韩生伟（1989—）,男,博士,副主任医师,E-mail: hsw071232003@163.com
基金资助:
国家自然科学基金面上项目（82473178）;南京市口腔医院高水平医院建设科研项目（0224C040）

Analysis of the expression of Glut-1 and HIF-1α in oral squamous cell carcinoma and their correlation with prognosis

Han Shengwei, Tang Chuanchao, Wang Yufeng, Han Wei

Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University. Nanjing 210008, Jiangsu Province, China

Received:2025-04-28 Revised:2025-05-30 Online:2026-03-20 Published:2026-04-02

摘要/Abstract

摘要： 目的: 探讨口腔鳞癌（oral squamous cell carcinoma,OSCC）组织中葡萄糖转运蛋白1（glucose transporter 1,Glut-1）和低氧诱导因子1α（hypoxia-inducible factor 1α,HIF-1α）的表达水平,及其与临床病理特征和患者预后的相关性。方法: 收集2018年1月至2019年12月南京大学医学院附属口腔医院80例OSCC患者的肿瘤组织标本,采用免疫组织化学染色法检测 Glut-1和HIF-1α的表达,分析其与患者临床病理特征及预后的相关性。结果: Glut-1的高表达与肿瘤分化程度显著相关（P=0.006）,低分化肿瘤中 Glut-1 表达更高;HIF-1α的高表达与肿瘤病理分级（P<0.001）及肿瘤大小（P=0.032）密切相关,高分级、体积较大的肿瘤中 HIF-1α表达更显著。Kaplan-Meier生存分析显示,Glut-1 和HIF-1α均高表达的患者预后最差（P=0.006）。Cox 多因素分析证实,Glut-1和 HIF-1α同时高表达是 OSCC 患者不良预后的独立危险因素（HR=2.787,P=0.022）。结论: Glut-1和HIF-1α的表达水平与OSCC分级密切相关,两者同时高表达的患者临床预后更差。

关键词: 口腔鳞癌, 葡萄糖转运蛋白1, 低氧诱导因子1, 预后

Abstract: PURPOSE: To investigate the expression levels of glucose transporter 1 (Glut-1) and hypoxia-inducible factor 1 α(HIF-1α) in oral squamous cell carcinoma (OSCC) tissues, and their correlation with clinicopathological features and patients' prognosis. METHODS: Tumor tissue samples from 80 OSCC patients treated in Nanjing Stomatological Hospital, Medical School of Nanjing University from January 2018 to December 2019 were collected. Immunohistochemical staining was used to detect the expression of Glut-1 and HIF-1α, and their correlation with clinicopathological features and prognosis of the patients was analyzed. RESULTS: The high expression of Glut-1 was significantly correlated with tumor differentiation (P=0.006), with higher Glut-1 expression in poorly differentiated tumors. The high expression of HIF-1α was closely related to tumor pathological grade (P<0.001) and tumor size (P=0.032), with stronger HIF-1α expression in high-grade and larger-sized tumors. Kaplan-Meier survival analysis showed that patients with high expression of both Glut-1 and HIF-1α had the worst prognosis (P=0.006). Cox multivariate analysis confirmed that simultaneous high expression of Glut-1 and HIF-1α was an independent risk factor for poor prognosis in OSCC patients(HR=2.787, P=0.022). CONCLUSIONS: The expression levels of Glut-1 and HIF-1α are closely related to OSCC tumor grading, and patients with simultaneous high expression of both have worse clinical prognosis.

Key words: Oral squamous cell carcinoma, Glucose transporter 1, Hypoxia-inducible factor 1, Prognosis

中图分类号:

R739.8

韩生伟, 汤传超, 王玉凤, 韩伟. Glut-1和HIF-1α在口腔鳞癌中的表达及与预后的相关性分析[J]. 中国口腔颌面外科杂志, 2026, 24(2): 105-109.

Han Shengwei, Tang Chuanchao, Wang Yufeng, Han Wei. Analysis of the expression of Glut-1 and HIF-1α in oral squamous cell carcinoma and their correlation with prognosis[J]. China J Oral Maxillofac Surg, 2026, 24(2): 105-109.

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Glut-1和HIF-1α在口腔鳞癌中的表达及与预后的相关性分析

Analysis of the expression of Glut-1 and HIF-1α in oral squamous cell carcinoma and their correlation with prognosis

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