口腔种植体周围菌群对种植体周围炎影响的meta分析

doi:10.19438/j.cjoms.2024.05.012

中国口腔颌面外科杂志 ›› 2024, Vol. 22 ›› Issue (5): 478-486.doi: 10.19438/j.cjoms.2024.05.012

口腔种植体周围菌群对种植体周围炎影响的meta分析

古丽斯旦·麦吾拉江¹, 李晨曦^1,2,*, 龚忠诚^1,*, 热依拉·居热提³, 姬晓炜⁴

1.新疆医科大学第一附属医院（附属口腔医院）口腔颌面肿瘤外科, 新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐 830054;
2.华中科技大学同济医学院附属协和医院口腔医学中心, 口腔颌面发育与再生湖北省重点实验室,湖北武汉 430022;
3.新疆医科大学第一附属医院（附属口腔医院）牙周病科,4.口腔修复种植科,新疆乌鲁木齐 830054

收稿日期:2023-12-11 修回日期:2024-01-15 出版日期:2024-09-20 发布日期:2024-09-29
通讯作者: 李晨曦,E-mail: lichenximed@163.com;龚忠诚,E-mail: gzc740904@xjmu.edu.cn。^*共同通信作者
作者简介:古丽斯旦·麦吾拉江（1987-）,女,本科,E-mail: 1102164894@qq.com
基金资助:
国家自然科学基金（82360481）; 口腔颌面发育与再生湖北省重点实验室开放课题基金（2022kqhm008）; 新疆维吾尔自治区科研创新项目（XJ2023G174）; 天山英才医药卫生领军人才(TSYC202301A001)

A PRISMA meta-analysis regarding the impact of surrounding bacteria of oral implant on periimplantitis

GULISIDAN·Maiwulajiang¹, LI Chen-xi^1,2, GONG Zhong-cheng¹, REYILA·jureti³, JI Xiao-wei⁴

1. Department of Oral and Maxillofacial Oncology & Surgery, the First Affiliated Hospital/Affiliated Stomatological Hospital of Xinjiang Medical University, Stomatological Research Institute of Xinjiang Uygur Autonomous Region. Urumqi 830054, Xinjiang Uygur Autonomous Region;
2. Center of Stomatology, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology; Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration. Wuhan 430022, Hubei Province;
3. Department of Periodontics, 4. Department of Prosthodontics and Dental Implantology, School/Hospital of Stomatology, First Affiliated Hospital of Xinjiang Medical University. Urumqi 830054, Xinjiang Uygur Autonomous Region, China

Received:2023-12-11 Revised:2024-01-15 Online:2024-09-20 Published:2024-09-29

摘要/Abstract

摘要： 目的: 系统评价细菌微生物与口腔种植体周围炎（periimplantitis,PI）发生的相关性。方法: 计算机检索Web of Science、PubMed、Scopus、Embase、CNKI和The Cochrane Library数据库,检索时限从建库至2023年12月,汇集PI受试者种植体周围菌群分布的临床研究。运用Stata 14.2和R 4.0.4软件,通过随机效应模型进行荟萃分析。使用改良纽卡斯尔-渥太华量表（the Newcastle-Ottawa Scale,NOS）及乔安娜·布里格斯研究所（Joanna Briggs Institute,JBI）报告检查表进行偏倚风险评价。结果: 共纳入13项研究,1 274例参与者（1 688个种植体）。Meta分析结果表明,PI与表皮葡萄球菌、牙龈卟啉单胞菌、福赛斯坦纳菌、齿垢密螺旋体、具核梭杆菌和中间普氏菌暴露有关（P均<0.05）。细菌计数作为结果和亚组分析的结果大多无有效结论。结论: PI与表皮葡萄球菌及特定牙周病原体（牙龈卟啉单胞菌、福赛斯坦纳菌、齿垢密螺旋体、具核梭杆菌和中间普氏菌）相关,但仍需继续完善多中心前瞻性队列研究以证实目前结论。

关键词: 种植体周围炎, 细菌, 微生物群, 风险因素, 临床预后

Abstract: PURPOSE: To systematically evaluate the correlation between bacterial microorganisms and periimplantitis pathogenesis. METHODS: Web of Science, PubMed, Scopus, Embase, CNKI, and The Cochrane Library were electronically retrieved to collect clinical studies related to bacterial distribution in subjects with periimplantitis from outset to December 2023. Meta analysis was performed using random-effect model by Stata 14.2 and R 4.0.4 software. Modified Newcastle-Ottawa Scale(NOS) and Joanna Briggs Institute(JBI) checklist were used to perform the risk of bias assessment. RESULTS: A total of thirteen studies, containing 1 274 participants(1 688 dental implants) were included. Compared with non-periimplantitis, periimplantitis was associated with the exposure of Staphylococcus epidermidis(S.e), Porphyromonas gingivalis (P.g), Tannerella forsythia (T.f), Treponema denticola (T.d), Fusobacterium nucleatum (F.n), and Prevotella intermedia(P.i) (P<0.05). Results of data synthesis for bacterial count as outcome and for subgroup analyses were mostly inconclusive. CONCLUSIONS: Periimplantitis is associated with the presence of S.e and specific periodontopathogens (P.g, T.f, T.d, F.n and P.i). However, multicentric prospective cohort studies are needed to confirm the present findings.

Key words: Periimplantitis, Bacteria, Microbiota, Risk factors, Clinical prognosis

中图分类号:

R782.1

古丽斯旦·麦吾拉江, 李晨曦, 龚忠诚, 热依拉·居热提, 姬晓炜. 口腔种植体周围菌群对种植体周围炎影响的meta分析[J]. 中国口腔颌面外科杂志, 2024, 22(5): 478-486.

GULISIDAN·Maiwulajiang, LI Chen-xi, GONG Zhong-cheng, REYILA·jureti, JI Xiao-wei. A PRISMA meta-analysis regarding the impact of surrounding bacteria of oral implant on periimplantitis[J]. China J Oral Maxillofac Surg, 2024, 22(5): 478-486.

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口腔种植体周围菌群对种植体周围炎影响的meta分析

A PRISMA meta-analysis regarding the impact of surrounding bacteria of oral implant on periimplantitis

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