特瑞普利单抗联合新辅助化疗治疗局部晚期可切除口腔鳞癌的效果评价

doi:10.19438/j.cjoms.2025.05.012

摘要/Abstract

摘要： 目的: 探讨特瑞普利单抗联合新辅助化疗治疗局部晚期可切除口腔鳞癌的效果。方法: 选择2020年1月—2022年1月在康复大学青岛中心医院接受治疗的口腔鳞癌患者98例,随机分为试验组和对照组,每组各49例。对照组接受新辅助化疗（白蛋白紫杉醇+顺铂）,试验组在对照组基础上联合应用特瑞普利单抗。治疗3周后行根治性手术。比较两组患者术后6个月的临床疗效,以及治疗前后的免疫功能、炎性因子水平、肿瘤标志物水平,并通过口腔健康影响程度量表（OHIP）和头颈肿瘤生活质量量表（UW-QOL）评估患者治疗前后的生活质量。治疗后随访2年,记录总生存期和生存率。结果: 试验组临床疗效和治疗后的免疫功能比对照组提高,且治疗后的炎性因子水平和肿瘤标志物比对照组降低,生活质量比对照组提高（P<0.05）。随访结果显示,试验组平均生存期和生存率均显著高于对照组（P<0.05）。结论: 特瑞普利单抗联合新辅助化疗可提高局部晚期可切除口腔鳞癌的临床疗效,改善患者生存状况。

关键词: 新辅助化疗, 特瑞普利单抗, 白蛋白紫杉醇, 顺铂, 口腔鳞癌, 生活质量

Abstract: PURPOSE: To evaluate the effectiveness of combining toripalimab with neoadjuvant chemotherapy for treating locally advanced resectable oral squamous cell carcinoma (OSCC). METHODS: A total of 98 patients with OSCC who received treatment in Qingdao Central Hospital, Rehabilitation University from January 2020 to January 2022 were randomly divided into experimental group and control group, with 49 cases in each group. The control group was treated with neoadjuvant chemotherapy consisting of albumin-bound paclitaxel and cisplatin, while the experimental group additionally received toripalimab on the basis of the control treatment. After 3 weeks of treatment, radical surgery was performed. The clinical efficacy at 6 months post-surgery, as well as immune function inflammatory cytokine levels, tumor markers, and quality of life before and after treatment were compared between the two groups using the Oral Health Impact Profile (OHIP) and University of Washington Quality of Life (UW-QOL) scales. A 2-year follow-up was conducted to record overall survival (OS) and survival rates. RESULTS: The experimental group showed improved clinical efficacy and immune function compared to the control group, with significantly lower inflammatory cytokine levels and tumor markers. Additionally, the experimental group exhibited a higher quality of life post-treatment (P<0.05). Follow-up results demonstrated that the experimental group had higher average OS and survival rates compared to the control group(P<0.05). CONCLUSIONS: Toripalimab in combination with neoadjuvant chemotherapy shows effectiveness in treating locally advanced resectable oral squamous cell carcinoma, enhancing clinical outcomes and survival rates.

Key words: Neoadjuvant chemotherapy, Toripalimab, Albumin-bound paclitaxel, Cisplatin, Oral squamous cell carcinoma, Quality of life

中图分类号:

R739.8

陈文健, 张弓, 纪业男, 宋蕾. 特瑞普利单抗联合新辅助化疗治疗局部晚期可切除口腔鳞癌的效果评价[J]. 中国口腔颌面外科杂志, 2025, 23(5): 502-507.

Chen Wenjian, Zhang Gong, Ji Yenan, Song Lei. Evaluation of the effect of toripalimab and neoadjuvant chemotherapy in treating locally advanced resectable oral squamous cell carcinoma[J]. China J Oral Maxillofac Surg, 2025, 23(5): 502-507.

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