牙龈卟啉单胞菌促进口腔鳞状细胞癌进展的作用及机制研究进展

doi:10.19438/j.cjoms.2023.02.015

摘要/Abstract

摘要： 大量研究表明,牙龈卟啉单胞菌（Porphyromonas gingivalis, P.gingivalis）是口腔鳞状细胞癌（oral squamous cell carcinoma,OSCC）的重要危险因素之一。P.gingivalis与OSCC的发生、发展、侵袭、转移及预后等因素高度相关。P. gingivalis可能的致病机制是通过抵抗及破坏宿主先天免疫系统、促进上皮-间质转化、促进侵袭和转移、抑制细胞凋亡、激活细胞的增殖等多种途径来促进OSCC的发生与发展。本文主要总结近年来P. gingivalis在OSCC进展中的作用及机制的最新研究进展。

关键词: 牙龈卟啉单胞菌, 口腔鳞状细胞癌, 作用机制

Abstract: A large number of studies have shown that P.gingivalis is one of the bacterial species, as an important risk factor, of oral squamous cell carcinoma (OSCC). P.gingivalis is closely associated with the pathogenicity, development, invasion, metastasis and prognosis of OSCC. For its potential mechanisms, it may accelerate OSCC occurrence and progress probably through multiple ways as follows: resisting and destroying the innate immune system of the host, promoting epithelial-mesenchymal transition, promoting cancerous invasion and metastasis, inhibiting cell apoptosis, activating cell proliferation. This review summarized the research progress in the role and mechanism of P.gingivalis in promoting OSCC.

Key words: Porphyromonas gingivalis, Oral squamous cell carcinoma, Mechanism of action

中图分类号:

R739.8

热孜万姑丽·亚森, 买热拍提·买明, 李晨曦, 龚忠诚. 牙龈卟啉单胞菌促进口腔鳞状细胞癌进展的作用及机制研究进展[J]. 中国口腔颌面外科杂志, 2023, 21(2): 186-190.

REZIWANGULI·Yasen, MAIREPATI·Maiming, LI Chen-xi, GONG Zhong-cheng. Research progress in the role and mechanism of Porphyromonas gingivalis in promoting oral squamous cell carcinoma[J]. China J Oral Maxillofac Surg, 2023, 21(2): 186-190.

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