肿瘤相关成纤维细胞对口腔鳞状细胞癌生物学行为影响的研究进展

doi:10.19438/j.cjoms.2024.01.015

摘要/Abstract

摘要： 口腔鳞状细胞癌（oral squamous cell carcinoma, OSCC）是全球第六大常见恶性肿瘤,其发生、发展与肿瘤微环境（tumor microenvironment, TME）密切相关。肿瘤相关成纤维细胞（cancer-associated fibroblasts, CAFs）作为TME中重要的组成成分,通过分泌多种生长因子、细胞因子、炎性因子、外泌体等参与上皮-间充质转化、重塑细胞外基质,激活多种生物学途径,对OSCC的发生、发展产生影响。本文对CAFs的来源、特点、异质性以及CAFs对OSCC的生物学行为的影响做一综述。

关键词: 肿瘤相关成纤维细胞, 肿瘤微环境, 口腔鳞状细胞癌

Abstract: Oral squamous cell carcinoma(OSCC) is the sixth most common malignant tumor in the world. The occurrence and development of oral cancer are closely related to tumor microenvironment (TME). Cancer-associated fibroblast (CAF) participated in epithelial-mesenchymal transition, remodel extracellular matrix, and activate various biological pathways by secreting various growth factors, cytokines, inflammatory factors, and exosomes, which are of great significance to the occurrence, development, and treatment of OSCC. This article reviews the origin, characteristics, heterogeneity of CAF, and the impact of CAF on the biological behavior of OSCC.

Key words: Cancer-associated fibroblast, Tumor microenvironment, Oral squamous cell carcinoma

中图分类号:

R739.8

韩林孜, 周建华, 董磊, 赵璐, 袁荣涛. 肿瘤相关成纤维细胞对口腔鳞状细胞癌生物学行为影响的研究进展[J]. 中国口腔颌面外科杂志, 2024, 22(1): 84-91.

HAN Lin-zi, ZHOU Jian-hua, DONG lei, ZHAO Lu, YUAN Rong-tao. Research progress on the effect of cancer-associated fibroblasts on biological behavior of oral squamous cell carcinoma[J]. China J Oral Maxillofac Surg, 2024, 22(1): 84-91.

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