口腔医疗中恶性高热临床诊治中国专家共识

doi:10.19438/j.cjoms.2020.01.001

中国口腔颌面外科杂志 ›› 2020, Vol. 18 ›› Issue (1): 1-9.doi: 10.19438/j.cjoms.2020.01.001

口腔医疗中恶性高热临床诊治中国专家共识

唐瞻贵¹, 步荣发², 郭伟³, 孙沫逸⁴, 郑家伟³, 彭歆⁵, 张惠⁶, 段小红⁷, 姜虹⁸, 王淼⁹, 张铁军¹⁰, 杨旭东¹¹, 杨凯¹², 喻建军¹³, 罗志勇¹⁴, 谢咏秋¹⁵, 胡延佳¹, 王柏胜¹

1.中南大学湘雅口腔医(学)院口腔颌面外科,湖南长沙 410013;
2.中国人民解放军总医院口腔颌面外科,北京 100853;
3.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,上海 200011;
4.空军军医大学(第四军医大学)口腔医学院口腔颌面外科,陕西西安 710032;
5.北京大学口腔医学院口腔颌面外科,北京 100081;
6.空军军医大学(第四军医大学)口腔医学院麻醉科;
7.口腔生物学教研室,陕西西安 710032;
8.上海交通大学医学院附属第九人民医院麻醉科,上海 200011;
9.四川大学华西口腔医院麻醉科,四川成都 610041;
10.武汉大学口腔医院麻醉科,湖北武汉 430072;
11.北京大学口腔医院麻醉科,北京 100081;
12.重庆医科大学附属第一医院口腔颌面外科,重庆 400016;
13.湖南省肿瘤医院头颈外科,湖南长沙 410006;
14.中南大学生命科学学院分子生物学研究中心,湖南长沙 410083;
15.中南大学湘雅医院麻醉科,湖南长沙 410008

收稿日期:2019-11-03 出版日期:2020-01-20 发布日期:2020-03-09
通讯作者: 唐瞻贵,E-mail:zhgtang@csu.edu.cn
作者简介:唐瞻贵(1964-),男,博士,教授,主任医师,博士研究生导师
基金资助:
国家自然科学基金(81671003)

Chinese expert consensus on diagnosis and clinical management of malignant hyperthermia in oral medicine

TANG Zhan-gui¹, BU Rong-fa², GUO Wei³, SUN Mo-yi⁴, ZHENG Jia-wei³, PENG Xin⁵, ZHANG Hui⁶, DUAN Xiao-hong⁷, JIANG Hong⁸, WANG Miao⁹, ZHANG Tie-jun¹⁰, YANG Xu-dong¹¹, YANG Kai¹², YU Jian-jun¹³, LUO Zhi-yong¹⁴, XIE Yong-qiu¹⁵, HU Yan-jia¹, WANG Bai-sheng¹

1.Department of Oral and Maxillofacial Surgery, Xiangya School of Stomatology, Central South University. Changsha 410013, Hunan Province;
2.Department of Oral and Maxillofacial Surgery, China PLA General Hospital. Beijing 100853;
3.Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
4.Department of Oral and Maxillofacial Surgery, School of Stomatology, Airforce Military Medical University. Xi'an 710032, Shaanxi Province;
5.Department of Oral and Maxillofacial Surgery, School of Stomatology, Peking University. Beijing 100081;
6.Department of Anesthesiology;
7.Oral Biology Section, School of Stomatology, Airforce Military Medical University. Xi'an 710032, Shaanxi Province;
8.Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
9.Department of Anesthesiology, West China School and Hospital of Stomatology, Sichuan University. Chengdu 610041, Sichuan Province;
10.Department of Anesthesiology, School and Hospital of Stomatology, Wuhan University. Wuhan 430070, Hubei Province;
11.Department of Anesthesiology, School of Stomatology, Peking University. Beijing 100081;
12.Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University. Chongqing 400016;
13.Head and Neck Surgery, Hunan Cancer Hospital. Changsha 410006, Hunan Province;
14.The Centre for Molecular Biodiscovery, School of Life Science, Central South University. Changsha 410083, Hunan Province;
15.Department of Anesthesiology, Xiangya Hospital, Central South University. Changsha 410078, Hunan Province, China

Received:2019-11-03 Online:2020-01-20 Published:2020-03-09

摘要/Abstract

摘要： 恶性高热(malignant hyperthermia,MH)是在有易感体质的患者中,由麻醉药或其他因素所诱发而出现的一系列病理生理及临床变化的特定性疾病。该病具有常染色体显性遗传特征,好发于青少年,可伴有唇腭裂等先天性疾病。由于各类麻醉药物在临床医学中的广泛应用,该病越来越受到广大临床医师的重视。MH的治疗手段有其特殊性,误诊和误治可能导致患者死亡等严重后果。制定口腔医学中MH临床诊治中国专家共识的目的,是希望广大口腔临床医师在诊疗过程中警惕MH的发生,减少误诊误治,提高患者的救治成功率。

关键词: 口腔医疗, 恶性高热, 临床诊治, 专家共识

Abstract: Malignant hyperthermia (MH) is an autosomal dominant disease induced by anesthetic drugs or other factors and present a series of pathologic physiology and clinical changes in patients with susceptibility. MH is prone to occur in adolescents, and patients may be accompanied by congenital diseases like cleft lip and palate. Due to the wide application of all kinds of anesthetic drugs in clinical procedures, this disease has attracted more and more attention from clinicians. The treatment of MH has its particularity, misdiagnosis and mistreatment may lead to serious consequences even death. The purpose of formulating the consensus of experts on MH in oral medicine is to hope that the majority of oral clinicians are alert to the occurrence of MH in the process of diagnosis and treatment, reduce misdiagnosis and mistreatment of MH, and improve the treatment success rate of patients.

Key words: Oral medicine, Malignant hyperthermia, Clinical diagnosis and treatment, Expert consensus

中图分类号:

R782

唐瞻贵, 步荣发, 郭伟, 孙沫逸, 郑家伟, 彭歆, 张惠, 段小红, 姜虹, 王淼, 张铁军, 杨旭东, 杨凯, 喻建军, 罗志勇, 谢咏秋, 胡延佳, 王柏胜. 口腔医疗中恶性高热临床诊治中国专家共识[J]. 中国口腔颌面外科杂志, 2020, 18(1): 1-9.

TANG Zhan-gui, BU Rong-fa, GUO Wei, SUN Mo-yi, ZHENG Jia-wei, PENG Xin, ZHANG Hui, DUAN Xiao-hong, JIANG Hong, WANG Miao, ZHANG Tie-jun, YANG Xu-dong, YANG Kai, YU Jian-jun, LUO Zhi-yong, XIE Yong-qiu, HU Yan-jia, WANG Bai-sheng. Chinese expert consensus on diagnosis and clinical management of malignant hyperthermia in oral medicine[J]. China J Oral Maxillofac Surg, 2020, 18(1): 1-9.

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口腔医疗中恶性高热临床诊治中国专家共识

Chinese expert consensus on diagnosis and clinical management of malignant hyperthermia in oral medicine

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