中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2026, Vol. 24 ›› Issue (5): 437-445.doi: 10.19438/j.cjoms.2026.05.001

• 专家共识 • 上一篇    下一篇

载rhBMP-2自固化磷酸钙人工骨在牙槽突裂植骨修复中应用的专家共识

蔡鸣1, 崔颖秋2, 李承浩3, 李健4, 李云鹏5, 任战平6, 宋涛7, 杨学财8, 周炼9, 朱洪平10, 王旭东1   

  1. 1.上海交通大学医学院附属第九人民医院 口腔颅颌面科,上海交通大学口腔医学院,国家口腔医学中心,口腔疾病国家临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011;
    2.广州医科大学附属妇女儿童医疗中心 口腔科,广东 广州 510180;
    3.四川大学华西口腔医院 唇腭裂外科,四川 成都 610041;
    4.武汉大学口腔医院 口腔颌面外科,湖北 武汉 430079;
    5.口腔疾病国家临床医学研究中心,口颌系统重建与再生全国重点实验室,陕西省口腔疾病临床医学研究中心,空军军医大学口腔医院 口腔颌面外科,陕西 西安 710032;
    6.西安交通大学口腔医院 唇腭裂外科,陕西 西安 710004;
    7.中国医学科学院整形外科医院 唇腭裂中心,北京 100144;
    8.青岛市妇女儿童医院 唇腭裂治疗中心,山东 青岛 266071;
    9.中国医学科学院北京协和医院 口腔科,北京 100730;
    10.北京大学口腔医院 口腔颌面外科,北京 100081
  • 收稿日期:2026-05-25 修回日期:2026-06-22 出版日期:2026-09-20 发布日期:2026-10-10
  • 通讯作者: 王旭东,E-mail: xudongwang70@hotmail.com
  • 作者简介:蔡鸣（1979—）,男,博士,副教授、主任医师,E-mail: zidanecm500@126.com
  • 基金资助:
    国家重点研发计划（2023YFC2414100; 2023YFC2414104）

Expert consensus on rhBMP-2/CPC for alveolar cleft bone grafting

Cai Ming1, Cui Yingqiu2, Li Chenghao3, Li Jian4, Li Yunpeng5, Ren Zhanping6, Song Tao7, Yang Xuecai8, Zhou Lian9, Zhu Hongping10, Wang Xudong1   

  1. 1. Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology. Shanghai 200011;
    2. Department of Stomatology, Women and Children's Medical Center of Guangzhou Medical University. Guangzhou 510180, Guangdong Province;
    3. Department of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University. Chengdu 610041, Sichuan Province;
    4. Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Wuhan University. Wuhan 430079, Hubei Province;
    5. National Clinical Research Center for Oral Diseases; State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration; Shaanxi Clinical Research Center for Oral Diseases; Department of Oral and Maxillofacial Surgery, School of Stomatology, Air Force Military Medical University. Xi'an 710032, Shaanxi Province;
    6. Department of Cleft Lip and Palate Surgery, Hospital of Stomatology, Xi'an Jiaotong University. Xi'an 710004, Shaanxi Province;
    7. Center of Cleft Lip and Palate, Plastic Surgery Hospital, Chinese Academy of Medical Sciences. Beijing 100144;
    8. Cleft Lip and Palate Treatment Center, Qingdao Women and Children's Hospital. Qingdao 266071, Shandong Province;
    9. Department of Stomatology, Peking Union Medical College Hospital. Beijing 100730;
    10. Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology. Beijing 100081, China
  • Received:2026-05-25 Revised:2026-06-22 Online:2026-09-20 Published:2026-10-10

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摘要： 牙槽突裂植骨是唇腭裂序列治疗的关键环节,可恢复牙槽突连续性、促进恒牙萌出及改善鼻基底支撑。自体髂骨松质骨目前仍为常用骨源,但供区疼痛、活动受限等并发症影响部分患者接受度。载重组人骨形态发生蛋白2自固化磷酸钙人工骨（rhBMP-2/CPC）兼具骨传导与骨诱导作用,在减少自体取骨需求及促进骨再生方面具有应用潜力,但其适应证、安全性及术后管理尚缺乏统一规范。目前该材料5年及以上长期随访数据不足,本共识为阶段性推荐意见。为促进其在牙槽突裂植骨修复中的合理应用,本共识由国家口腔医学中心（上海）牵头,组织相关领域专家,基于现有循证医学证据和临床经验,采用GRADE体系,就rhBMP-2/CPC的适用人群、并发症风险、对牙萌出及正畸牙移动的影响、补救性植骨策略及术后影像学随访等问题形成推荐意见,供口腔颌面外科及相关专业医师参考。

关键词: 牙槽突裂, 牙槽突裂植骨, 重组人骨形态发生蛋白2, 自固化磷酸钙, 人工骨, 专家共识

Abstract: Alveolar bone grafting is an essential component of comprehensive cleft lip and palate management. It restores alveolar continuity, facilitates eruption of permanent teeth, and improves support of the nasal base. Autogenous cancellous bone harvested from the iliac crest remains the most commonly used grafting material; however, donor-site morbidity, including postoperative pain and limited mobility, may affect patients’ acceptance. Recombinant human bone morphogenetic protein-2-loaded self-setting calcium phosphate cement artificial bone (rhBMP-2/CPC) combines osteoinductive and osteoconductive properties and has shown potential for reducing the need for autogenous bone harvesting while promoting bone regeneration. Nevertheless, standardized guidance regarding its indications, safety profile, and postoperative management in alveolar cleft reconstruction remains limited. At present, there is insufficient long-term follow-up data (more than 5 years) for this material. This consensus represents interim recommendations. To promote the appropriate clinical application of rhBMP-2/CPC in alveolar cleft bone grafting, this expert consensus was developed under the leadership of the National Center for Stomatology, Shanghai, with contributions from multidisciplinary experts in relevant fields. Based on the best available evidence, expert clinical experience, and the GRADE framework, recommendations were formulated regarding patient selection, complication risks, effects on tooth eruption and orthodontic tooth movement, strategies for revision or salvage bone grafting, and postoperative radiographic evaluation and follow-up. This consensus is intended to provide practical guidance for oral and maxillofacial surgeons and related specialists involved in the management of alveolar cleft defects.

Key words: Alveolar cleft, Cleft lip and palate, Alveolar cleft bone grafting, Recombinant human bone morphogenetic protein-2, Calcium phosphate cement, Expert consensus

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