中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2019, Vol. 17 ›› Issue (6): 535-539.doi: 10.19438/j.cjoms.2019.06.011

• 论著 • 上一篇    下一篇

79例头颈部牙源性黏液瘤临床、病理及预后分析

孙中毅1#, 陈一铭2#, 唐妍毅3,*, 季彤2,*   

  1. 1.黑龙江佳木斯市中心医院 口腔颌面外科,黑龙江 佳木斯 154000;
    2.上海交通大学医学院附属第九人民医院·口腔医学院 口腔颌面-头颈肿瘤科;
    3.口腔综合科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海200011
  • 收稿日期:2019-04-01 出版日期:2019-11-20 发布日期:2019-12-16
  • 通讯作者: 季彤,E-mail: jitongjitong@foxmail.com;唐妍毅,E-mail: tyy-85121@126.com。*共同通信作者
  • 作者简介:孙中毅（1984-）,男,硕士,E-mail: szy19840302@163.com; 陈一铭（1989-）,男,硕士,E-mail: 781368531@qq.com。#并列第一作者。

Head and neck odontogenic myxoma: clinical, pathological and prognosis analysis of 79 consecutive cases

SUN Zhong-yi1, CHEN Yi-ming2, TANG Yan-yi3, JI Tong2   

  1. 1.Department of Oral and Maxillofacial Surgery, Jiamusi Center Hospital. Jiamusi 154000, Heilongjiang Province;
    2.Department of Oromaxillofacial Head and Neck Oncology;
    3.Department of General Dentistry, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Disease; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology. Shanghai 200011, China
  • Received:2019-04-01 Online:2019-11-20 Published:2019-12-16

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摘要： 目的: 研究头颈部牙源性黏液瘤的临床、病理及预后特点。方法: 回顾2001—2017年于上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科接受手术治疗的头颈部黏液瘤患者的临床、病理及预后信息,采用SPSS 17.0软件包对数据进行统计学分析。结果: 纳入患者79例,其中可随访71例。可随访患者中,男30例,女41例。年龄≤30岁27例,31~60岁39例。12例有吸烟史,3例有酗酒史。12例接受过手术治疗;42例发生于下颌骨,26例发生于上颌骨及颅底。肿瘤最大直径中位值为3.5 cm,36例肿瘤最大直径≤3.5 cm。60例接受肿瘤根治性切除,11例接受局部刮治术。52例瘤体组织以纤维成分为主,19例以黏液成分为主;随访期间4例出现局部复发。接受局部刮治术的患者,术后复发率（36.36%）显著高于接受肿瘤根治性切除的患者（P=0.001）。结论: 头颈部牙源性黏液瘤是一种较为罕见的良性肿瘤,具备局部侵袭性,下颌骨发病较常见,患者年龄以31~60岁为主。相对于局部刮治术,根治性切除可有效抑制肿瘤术后复发。

关键词: 牙源性黏液瘤, 头颈部, 根治性切除, 局部刮治术

Abstract: PURPOSE: To analyze the clinical pathological and prognosis factors of head and neck odontogenic myxoma. METHODS: A retrospective study was adapted for patients who received surgery in the Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital from 2001-2017. Clinical, pathological and prognosis data were collected and analyzed with SPSS 17.0 software package. RESULTS: Seventy-nine patients were finally selected, 71 could be followed up. Among 71 patients, 30 were male; 27 were ≤30 years, 39 were within 31-60 years. Twelve had smoking history, 3 had alcoholism history. Forty-two had tumor in mandible, 26 had tumor in the maxilla and skull base. The median of the largest diameter tumor was 3.5 cm, 36 were ≤3.5 cm. Sixty received block resection, 11 underwent curettage. Fifty-two were rich in fibrous content while 19 were rich in mucus content. Four had local recurrence within follow-up period. Patients receiving curettage had higher rate of local recurrence (36.36%) compared while those with block resection (P=0.001). CONCLUSIONS: Head and neck odontogenic myxoma was a kind of benign tumor with local recurrence, mostly located in the mandible and high incidence in patients within 31-60 years old. Block resection can provide good control of local recurrence compared with curettage.

Key words: Odontogenic myxoma, Head and neck, Block resection, Curettage

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