头颈部腺样囊性癌预后分析：单中心经验

doi:10.19438/j.cjoms.2023.05.007

中国口腔颌面外科杂志 ›› 2023, Vol. 21 ›› Issue (5): 467-471.doi: 10.19438/j.cjoms.2023.05.007

头颈部腺样囊性癌预后分析：单中心经验

程煜天, 徐乐, 马利, 吴海威, 陈占伟, 邹虎威, 张天奇, 刘桂军, 刘振兴, 尹长伟, 李文刚, 张世周, 黄圣运^*, 张东升^*

山东第一医科大学附属省立医院口腔颌面外科,山东济南 250021

收稿日期:2023-01-09 修回日期:2023-03-07 出版日期:2023-09-20 发布日期:2023-10-11
通讯作者: 张东升,E-mail：ds63zhang@sdu.edu.cn;黄圣运,E-mail：huangsy28@sdu.edu.cn。^*共同通信作者
作者简介:程煜天（1988-）男,硕士,主治医师,E-mail：cyt880604@126.com
基金资助:
山东省自然科学基金（ZR2021MH270）; 中国博士后科学基金（2019M652380）; 济南市临床医学科技创新计划（202134035）; 山东省口腔组织再生重点实验室开放课题（SDDX202105）

Prognosis of adenoid cystic carcinoma in head and neck region: a single-centre experience

CHENG Yu-tian, XU Le, MA Li, WU Hai-wei, CHEN Zhan-wei, ZOU Hu-wei, ZHANG Tian-qi, LIU Gui-jun, LIU Zhen-xing, YIN Chang-wei, LI Wen-gang, ZHANG Shi-zhou, HUANG Sheng-yun, ZHANG Dong-sheng

Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University. Jinan 250021, Shandong Province, China

Received:2023-01-09 Revised:2023-03-07 Online:2023-09-20 Published:2023-10-11

摘要/Abstract

摘要： 目的：通过探讨头颈部腺样囊性癌(adenoid cystic carcinoma, ACC)的临床特点,分析影响其生存、复发、转移等预后的因素。方法：回顾性收集2010年1月—2020年12月在山东第一医科大学附属省立医院口腔颌面外科就诊的188例腺样囊性癌患者的临床资料,进行门诊或电话随访,采用SPSS 26.0软件包中的Kaplan-Meier法评估生存情况,应用Cox回归分析对其相关预后因素进行分析。结果：188例患者总体生存率为76.6%,其中因复发死亡13.3%,远处转移死亡10.1%。复发率23.9%,转移率10.1%。其中复发患者生存率42.2%,转移患者生存率为68.4%。Cox回归分析结果显示,年龄、肿瘤原发灶大小、区域淋巴结转移和治疗方式为影响患者生存率的预后因素。结论：患者年龄、T分期、N分期和治疗方式为影响腺样囊性癌患者生存率的预后因素,患者年龄、神经侵犯为影响腺样囊性癌患者复发的预后因素,患者N分期为影响腺样囊性癌患者转移的预后因素。

关键词: 腺样囊性癌, 头颈部, 预后分析

Abstract: PURPOSE: To explore the prognostic factors of adenoid cystic carcinoma (ACC) in head and neck region by analyzing associated clinical characters. METHODS: A total of 188 patients with ACC in head and neck region were enrolled, and the follow-up was carried out by outpatient review or telephone. Kaplan-Meier method was used to assess the survival rates, and Cox regression analysis was used to identify the associated prognostic factors with SPSS 26.0 software package. RESULTS: The overall survival rate of 188 patients was 76.6%, of which 13.3% died of recurrence and 10.1% died of distant metastasis. The rate of local recurrence and distant metastasis were 23.9% and 10.1%, of which the survival rate was 42.2% and 68.4%, respectively. Cox regression analysis revealed that age, T stage, N stage, and regimens were significantly associated with survival of ACC. CONCLUSIONS: In ACC, age, T stage, N stage, and regimen were independent prognostic factors of survival, age and nerve invasion were independent prognostic factors of recurrence, and N stage was independent prognostic factor of distant metastasis.

Key words: Adenoid cystic carcinoma, Head and neck region, Prognosis analysis

中图分类号:

R739.8

程煜天, 徐乐, 马利, 吴海威, 陈占伟, 邹虎威, 张天奇, 刘桂军, 刘振兴, 尹长伟, 李文刚, 张世周, 黄圣运, 张东升. 头颈部腺样囊性癌预后分析：单中心经验[J]. 中国口腔颌面外科杂志, 2023, 21(5): 467-471.

CHENG Yu-tian, XU Le, MA Li, WU Hai-wei, CHEN Zhan-wei, ZOU Hu-wei, ZHANG Tian-qi, LIU Gui-jun, LIU Zhen-xing, YIN Chang-wei, LI Wen-gang, ZHANG Shi-zhou, HUANG Sheng-yun, ZHANG Dong-sheng. Prognosis of adenoid cystic carcinoma in head and neck region: a single-centre experience[J]. China J Oral Maxillofac Surg, 2023, 21(5): 467-471.

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头颈部腺样囊性癌预后分析：单中心经验

Prognosis of adenoid cystic carcinoma in head and neck region: a single-centre experience

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