东北地区274例腭裂患者临床特征与ABO血型分析

doi:10.19438/j.cjoms.2018.02.010

中国口腔颌面外科杂志 ›› 2018, Vol. 16 ›› Issue (2): 149-152.doi: 10.19438/j.cjoms.2018.02.010

东北地区274例腭裂患者临床特征与ABO血型分析

史春玲, 李铎, 刘奕

中国医科大学附属口腔医院奉天门诊,辽宁沈阳 110013

收稿日期:2017-10-11 修回日期:2017-12-14 出版日期:2018-03-20 发布日期:2018-04-08
通讯作者: 刘奕,E-mail:liuyi256@126.com
作者简介:史春玲（1990-）,女,在读硕士研究生,E-mail:chunlingshi@163.com
基金资助:
辽宁省教育厅科学研究一般项目（L2015584）; 辽宁省科学事业公益研究基金(2015005003)

Association of ABO blood groups with cleft palate in 274 patients in the northeast China

SHI Chun-ling, LI Duo, LIU Yi

Fengtian Dental Clinic, School of Stomatology, China Medical University . Shenyang 110013, Liaoning Province, China;

Received:2017-10-11 Revised:2017-12-14 Online:2018-03-20 Published:2018-04-08

摘要/Abstract

摘要： 目的: 研究腭裂发生与ABO血型之间的关系。 方法: 选择2012年10月—2017年1月于中国医科大学附属口腔医院就诊的274例汉族腭裂患者（年龄为0~61岁）作为病例组,其中男113例,女161例（男∶女=1∶1.42）;对照组为本院就诊的978例非唇腭裂患者。采用SPSS 22.0软件包对腭裂患者和对照组ABO血型分布进行统计学分析。 结果: 腭裂患者血型频率特征与对照组均为B>O>A>AB, χ²检验显示腭裂患者与对照组血型分布间差异无显著性（P>0.05）。先天性腭裂中,不完全性腭裂与单侧完全性腭裂（75.55%）最多见,其次为黏膜下腭裂（22.26%）,双侧完全性腭裂（2.19%）最少见。腭裂患者女性(58.76%)多于男性(41.24%),农村患者（54.74%）多于城镇患者（45.26%）。 结论: 先天性腭裂中不完全性腭裂与单侧完全性腭裂最多见,其次为黏膜下腭裂,双侧完全性腭裂最少见。腭裂发生与ABO血型无关,可能与性别、城乡有关。

关键词: 腭裂, ABO血型, 遗传分析

Abstract: PURPOSE: To evaluate the relation between blood grouping and the presence of cleft palate. METHODS: From October 2012 to January 2017,the clinical records of 274 patients (age range 0-61 years) with congenital cleft palate who were treated at the Stomatological Hospital of China Medical University were selected as case group. There were 113 males and 161 females(male:female=1:1.42); the control group was consisted of 978 patients without cleft lip and/or palate who visited the hospital due to other problems. Statistical analysis was performed on the blood group distribution of patients with cleft palate and the control group using SPSS 22.0 software package. RESULTS: Blood type frequency of patients with cleft palate and controls was B>O>A>AB. Chi-square test showed that association of blood groups with cleft palate was not statistically significant(P>0.05).Congenital incomplete cleft palate and unilateral complete cleft palate(75.55%) were the most common types, followed by submucosal cleft palate(22.26%) and bilateral complete cleft palate(2.19%) was the least one. Women with cleft palate (58.76%) were more than men (41.24%) and the rural patients(54.74%) were more than the urban ones(45.26%). CONCLUSIONS: Congenital incomplete cleft palate and unilateral complete cleft palate are the most common types, followed by submucosal cleft palate and bilateral complete cleft palate is the least one. The occurrence of cleft palate is unrelated to ABO blood groups, it is possibly related to gender and urban and rural areas.

Key words: Cleft palate, ABO blood groups, Genetic analysis

中图分类号:

R783.5

史春玲, 李铎, 刘奕. 东北地区274例腭裂患者临床特征与ABO血型分析[J]. 中国口腔颌面外科杂志, 2018, 16(2): 149-152.

SHI Chun-ling, LI Duo, LIU Yi. Association of ABO blood groups with cleft palate in 274 patients in the northeast China[J]. China J Oral Maxillofac Surg, 2018, 16(2): 149-152.

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东北地区274例腭裂患者临床特征与ABO血型分析

Association of ABO blood groups with cleft palate in 274 patients in the northeast China

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