自体牙骨粉联合CGF在阻生下颌第三磨牙拔除术后第二磨牙远中骨缺损修复中的应用效果评价

doi:10.19438/j.cjoms.2025.03.011

摘要/Abstract

摘要： 目的：探讨自体牙骨粉联合浓缩生长因子（concentrated growth factors,CGF）在阻生下颌第三磨牙拔除术后第二磨牙远中骨缺损修复中的应用效果。方法：选择2023年6月—2024年6月就诊于新疆医科大学第一附属医院的25例双侧下颌阻生第三磨牙拔除术后第二磨牙远中骨缺损患者,采用自身双侧对照试验,一侧为试验组（25例）,另一侧为对照组（25例）。试验组骨缺损处给予自体牙骨粉联合CGF治疗,对照组骨缺损处给予CGF治疗。比较2组患者术后牙周探诊深度（probing depth,PD）、临床附着丧失（clinical attachment level,CAL）、骨缺损深度（osseous defect depth,ODD）、骨密度、手术时间、术后症状严重程度量表（Postoperative Symptom Severity Scale,PoSSe）评分、邻牙敏感度、术后感染及下唇麻木。采用SPSS 26.0软件包对数据进行统计学分析。结果：2组患者术后3、6个月的PD、CAL显著低于术后2周（P<0.001）;术后6个月试验组PD减少率、CAL减少率显著高于对照组（P<0.001）;试验组术后3、6个月ODD减少量显著大于对照组（P<0.001）;试验组与对照组术后3、6个月骨密度比较,具有显著差异。试验组手术时间显著大于对照组（P<0.001）。2组患者术后PoSSe量表评分在言语、外观、疼痛方面具有统计学差异（P<0.05）;对照组第二磨牙远中牙敏感发生率显著高于试验组（P<0.05）。结论：自体牙骨粉联合CGF能有效促进第二磨牙远中骨缺损恢复,改善第二磨牙远中牙周情况,具有较高的临床应用价值。CGF也可改善第二磨牙远中骨缺损深度,但骨缺损高度恢复不明显,远期效果不佳。

关键词: 下颌第三磨牙, 下颌第二磨牙, 骨缺损, 骨修复, 自体牙骨粉, 浓缩生长因子

Abstract: PURPOSE: To investigate the effect of autogenous tooth bone powder combined with concentrated growth factors (CGF) in the repair of distal bone defects in the second molar after impacted mandibular third molar extraction. METHODS: A total of 25 patients with distal bone defect of second molar after bilateral mandibular impacted third molar extraction were selected in the First Affiliated Hospital of Xinjiang Medical University from June 2023 to June 2024. A bilateral controlled experiment was conducted, with one side as the experimental group (n=25) and the other side as the control group (n=25). The experimental group received treatment with autogenous tooth powder combined with CGF, while the control group received CGF treatment alone. Postoperative probing depth(PD), clinical attachment loss(CAL), osseous defect depth(ODD), bone mineral density, operative time, Postoperative Symptom Severity Scale(PoSSe), adjacent tooth hypersensitivity, postoperative infection, and numbness of lower lip were compared between the two groups. SPSS 26.0 software package was used for data analysis. RESULTS: At 3 and 6 months postoperatively, the PD and CAL in both groups were significantly lower than those at 2 weeks postoperatively (P<0.001); the reduction rates of PD and CAL in the experimental group were significantly higher than those in the control group at 6 months postoperatively (P<0.001); the reduction amount of ODD in the experimental group was significantly higher than that in the control group at 3 and 6 months postoperatively (P<0.001). There were significant differences in bone density between the experimental group and the control group at 3 and 6 months postoperatively. The operation time in the experimental group was longer than that in the control group, with a statistically significant difference. The postoperative PoSSe scores for speech, appearance, and pain showed significant different between the two groups (P<0.05). The incidence of distal tooth sensitivity of the second molar in the control group was significantly higher than that in the experimental group(P<0.05). CONCLUSIONS: Autogenous tooth bone powder combined with CGF can effectively promote the recovery of distal bone defects in the second molar, improve the periodontal condition of the distal second molar, and has high clinical application value. CGF alone can also improve the depth of distal bone defects in the second molar, but the recovery of the height of the bone defect is not obvious, and the long-term effect is not good.

Key words: Mandibular third molar, Mandibular second molar, Bone defect, Bone regeneration, Autogenous tooth powder, Concentrated growth factors

中图分类号:

R782.1

岳丽, 王珊, 马金凤, 王玲. 自体牙骨粉联合CGF在阻生下颌第三磨牙拔除术后第二磨牙远中骨缺损修复中的应用效果评价[J]. 中国口腔颌面外科杂志, 2025, 23(3): 276-283.

Yue Li, Wang Shan, Ma Jinfeng, Wang Ling. Autogenous tooth bone powder combined with CGF for the repair of distal bone defects in the second molar after impacted mandibular third molar extraction[J]. China J Oral Maxillofac Surg, 2025, 23(3): 276-283.

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