自体骨移植修复牙槽骨缺损的研究进展

doi:10.19438/j.cjoms.2025.01.015

摘要/Abstract

摘要： 骨移植技术在种植前骨增量中应用广泛,临床上常用的骨移植材料有自体骨,同种异体骨、异种骨和人工合成骨材料。其中,自体骨具有骨生长的3大特性：骨传导、骨诱导以及骨生成作用,被视为骨移植的金标准。本文针对种植前的自体骨移植进行综述,从移植物的结构、形态、取骨部位、取骨方法等方面进行总结,并展望自体骨移植的应用前景。

关键词: 自体骨移植, 骨增量, 口腔种植, 牙槽骨缺损

Abstract: Bone grafts are widely used in bone augmentation before implantation. The commonly used bone grafts are autogenous bone, allogeneic bone, xenogeneic bone and synthetic materials. Autologous bone graft is regarded as the gold standard of bone transplantation since it has three properties: bone conduction, bone induction and bone formation. This article reviewed the autologous bone transplantation technique before implantation, summarized the structure, morphology, harvesting sites and methods and previewed the application of autologous bone transplantation.

Key words: Autologous bone graft, Bone augmentation, Oral implantology, Alveolar bone defect

中图分类号:

R782.1

刘自华, 徐光宙. 自体骨移植修复牙槽骨缺损的研究进展[J]. 中国口腔颌面外科杂志, 2025, 23(1): 84-93.

LIU Zi-hua, XU Guang-zhou. Research progress of autogenous bone graft in repairing alveolar bone defect[J]. China J Oral Maxillofac Surg, 2025, 23(1): 84-93.

参考文献

[1] Lee D, Lee Y, Kim S, et al.Evaluation of regeneration after the application of 2 types of deproteinized bovine bone mineral to alveolar bone defects in adult dogs[J]. J Periodontal Implant Sci, 2022, 52(5): 370-382.
[2] Moussa NT, Dym H.Maxillofacial bone grafting materials[J]. Dent Clin North Am, 2020, 64(2): 473-490.
[3] Chavda S, Levin L.Human studies of vertical and horizontal alveolar ridge augmentation comparing different types of bone graft materials: a systematic review[J]. J Oral Implantol, 2018, 44(1): 74-84.
[4] Fretwurst T, Gad LM, Nelson K, et al.Dentoalveolar reconstruction: modern approaches[J]. Curr Opin Otolaryngol Head Neck Surg, 2015, 23(4): 316-322.
[5] Meza-Mauricio J, Furquim CP, Dos Reis LD, et al.How efficacious is the combination of substitute bone graft with autogenous bone graft in comparison with substitute bone graft alone in the horizontal bone gain? a systematic review and meta-analysis[J]. J Clin Exp Dent, 2022,14(8): e678-e688.
[6] Rao RR, Stegemann JP.Cell-based approaches to the engineering of vascularized bone tissue[J]. Cytotherapy, 2013, 15(11): 1309-1322.
[7] Wang HL, Boyapati L."PASS" principles for predictable bone regeneration[J]. Implant Dent, 2006, 15(1): 8-17.
[8] Alzahrani BK, Fatani B, Alshalawi HS, et al.Survival of dental implants placed in iliac, fibula, and radial forearm flaps: a comprehensive review[J]. Cureus, 2023, 15(10): e48031.
[9] Ebad Ali SM, Razak S, Khan WF, et al.Outcomes of reconstruction with vascularized vs non vascularized bone graft after resection of bone tumours- a systematic review and meta-analysis[J]. J Ayub Med Coll Abbottabad, 2023, 35(2): 307-312.
[10] Ardisson A, de Senna PM, Granato R, et al. Success rate of mandible implants placed in vascularized fibula bone graft: a systematic review[J]. J Oral Implantol, 2023, 49(1): 85-92.
[11] El Zahwy M, Taha S, Mounir R, et al.Assessment of vertical ridge augmentation and marginal bone loss using autogenous onlay vs inlay grafting techniques with simultaneous implant placement in the anterior maxillary esthetic zone: a randomized clinical trial[J]. Clin Implant Dent Relat Res, 2019, 21(6): 1140-1147.
[12] Starch-Jensen T, Nielsen HB.Sandwich osteotomy of the atrophic posterior mandible with interpositional autogenous bone block graft compared with bone substitute material: a systematic review and meta-analysis[J]. Br J Oral Maxillofac Surg, 2020, 58(10): e237-e247.
[13] Kamperos G, Zografos I, Tzermpos F, et al.Segmental sandwich osteotomy of the posterior mandible in pre-implant surgery-a systematic review[J]. Med Oral Patol Oral Cir Bucal, 2017, 22(1): e132-e141.
[14] Pape HC, Evans A, Kobbe P.Autologous bone graft: properties and techniques[J]. J Orthop Trauma, 2010, 24(Suppl 1): S36-S40.
[15] Li Y, Li D, Tang Z, et al.Current global research on mandibular defect: a bibliometric analysis from 2001 to 2021[J]. Front Bioeng Biotechnol, 2023, 11: 1061567.
[16] Dragan E, Nemtoi A.Review of the long-term outcomes of guided bone regeneration and autologous bone block augmentation for vertical dental restoration of dental implants[J]. Med Sci Monit, 2022,28: e937433.
[17] Walsh WR, Pelletier MH, Bertollo N, et al.Bone ongrowth and mechanical fixation of implants in cortical and cancellous bone[J]. J Orthop Surg Res, 2020, 15(1): 177-186.
[18] Zhao R, Yang R, Cooper PR, et al.Bone grafts and substitutes in dentistry: a review of current trends and developments[J]. Molecules, 2021, 26(10): 3007.
[19] Zhang W, Yelick PC.Craniofacial tissue engineering[J]. Cold Spring Harb Perspect Med, 2018, 8(1): a025775.
[20] Verdugo F, D'Addona A, Pontón J. Clinical, tomographic, and histological assessment of periosteal guided bone regeneration with cortical perforations in advanced human critical size defects[J]. Clin Implant Dent Relat Res, 2012, 14(1): 112-120.
[21] Sheikh Z, Hamdan N, Ikeda Y, et al.Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review[J]. Biomater Res, 2017,21: 9.
[22] Hamada T, Matsubara H, Hikichi T, et al.Rat model of an autologous cancellous bone graft[J]. Sci Rep, 2021, 11(1): 18001.
[23] Buck DW, 2nd, Dumanian GA. Bone biology and physiology: part I. the fundamentals[J]. Plast Reconstr Surg, 2012, 129(6): 1314-1320.
[24] Bauer TW, Muschler GF.Bone graft materials. an overview of the basic science[J]. Clin Orthop Relat Res, 2000(371): 10-27.
[25] Sass T, Bálint G, Koffol T, et al.Augmentation of the vertical bone defects of the mandible and maxilla with autogenous bone block[J]. Orv Hetil, 2022, 163(14): 558-563.
[26] Pourabbas R, Nezafati S.Clinical results of localized alveolar ridge augmentation with bone grafts harvested from symphysis in comparison with ramus[J]. J Dent Res Dent Clin Dent Prospects, 2007, 1(1): 7-12.
[27] Park YH, Choi SH, Cho KS, et al.Dimensional alterations following vertical ridge augmentation using collagen membrane and three types of bone grafting materials: a retrospective observational study[J]. Clin Implant Dent Relat Res, 2017, 19(4): 742-749.
[28] Aloy-Prósper A, Peñarrocha-Oltra D, Peñarrocha-Diago M, et al.The outcome of intraoral onlay block bone grafts on alveolar ridge augmentations: a systematic review[J]. Med Oral Patol Oral Cir Bucal, 2015, 20(2): e251-e258.
[29] Gandhi V, Lowney A, Cardarelli L, et al.Three-dimensional evaluation of the mandibular symphyseal region in block graft harvesting for dental implants using cone-beam computed tomography[J]. Imaging Sci Dent, 2020, 50(3): 217-226.
[30] Sbordone C, Toti P, Guidetti F, et al.Volume changes of iliac crest autogenous bone grafts after vertical and horizontal alveolar ridge augmentation of atrophic maxillas and mandibles: a 6-year computerized tomographic follow-up[J]. J Oral Maxillofac Surg, 2012, 70(11): 2559-2565.
[31] 史远, 杨国利. 外斜线取骨自体骨移植及其他牙槽嵴骨增量法的研究进展[J]. 口腔医学, 2021, 41(6): 557-560, 571.
Shi Y, Yang GL.Research progress of external oblique bone autotransplantation and other alveolar ridge bone augmentation methods[J]. Stomatology, 2021, 41(6): 557-560, 571.
[32] Sugg KB, Rosenthal AH, Ozaki W, et al.Quantitative comparison of volume maintenance between inlay and onlay bone grafts in the craniofacial skeleton[J]. Plast Reconstr Surg, 2013, 131(5): 1014-1021.
[33] Sbordone L, Toti P, Menchini-Fabris GB, et al.Volume changes of autogenous bone grafts after alveolar ridge augmentation of atrophic maxillae and mandibles[J]. Int J Oral Maxillofac Surg, 2009, 38(10): 1059-1065.
[34] 唐世杰, 石伦刚. 牙槽突裂植骨吸收的原因与对策[J]. 中国实用口腔科杂志, 2012, 5(6): 332-336.
Tang SJ, Shi LG.Causes and countermeasures of bone graft resorption in alveolar cleft[J]. Chinese Journal of Practical Stomatology, 2012, 5(6): 332-336.
[35] Maiorana C, Beretta M, Salina S, et al.Reduction of autogenous bone graft resorption by means of Bio-Oss coverage: a prospective study[J]. Int J Periodontics Restorative Dent, 2005, 25(1): 19-25.
[36] Urban IA, Nagursky H, Lozada JL, et al.Horizontal ridge augmentation with a collagen membrane and a combination of particulated autogenous bone and anorganic bovine bone-derived mineral: a prospective case series in 25 patients[J]. Int J Periodontics Restorative Dent, 2013, 33(3): 299-307.
[37] Roccuzzo M, Savoini M, Dalmasso P, et al.Long-term outcomes of implants placed after vertical alveolar ridge augmentation in partially edentulous patients: a 10-year prospective clinical study[J]. Clin Oral Implants Res, 2017, 28(10): 1204-1210.
[38] Cordaro L, Torsello F, Morcavallo S, et al.Effect of bovine bone and collagen membranes on healing of mandibular bone blocks: a prospective randomized controlled study[J]. Clin Oral Implants Res, 2011, 22(10): 1145-1150.
[39] 满毅, 王天璐. 钛网在口腔种植骨量扩增中的应用[J]. 口腔颌面外科杂志, 2015, 25(4): 241-245.
Man Y, Wang TL.Application of titanium mesh in bone mass expansion in oral implants[J]. Journal of Oral and Maxillofacial Surgery, 2015, 25(4): 241-245.
[40] de Azevedo RA, Matos FS, Figueiredo LMG. Appositional bone graft tunneled: technical note[J]. Int J Surg Case Rep, 2017, 33: 143-147.
[41] Levin BP, Chu SJ.Ridge augmentation simultaneous with immediate implant placement: the subperiosteal tunneling technique[J]. Compend Contin Educ Dent, 2018, 39(5): 304-309.
[42] Kakar A, Kakar K, Sripathi Rao BH, et al.Lateral alveolar ridge augmentation procedure using subperiosteal tunneling technique: a pilot study[J]. Maxillofac Plast Reconstr Surg, 2018, 40(1): 3-10.
[43] Lima JLO, Sendyk DI, Sendyk WR, et al.Growth dynamic of allogeneic and autogenous bone grafts in a vertical model[J]. Braz Dent J, 2018, 29(4): 325-334.
[44] Clementini M, Morlupi A, Agrestini C, et al.Success rate of dental implants inserted in autologous bone graft regenerated areas: a systematic review[J]. Oral Implantol (Rome), 2011, 4(3-4): 3-10.
[45] Kuchler U, von Arx T. Horizontal ridge augmentation in conjunction with or prior to implant placement in the anterior maxilla: a systematic review[J]. Int J Oral Maxillofac Implants, 2014, 29(Suppl): 14-24.
[46] Miron RJ, Gruber R, Hedbom E, et al.Impact of bone harvesting techniques on cell viability and the release of growth factors of autografts[J]. Clin Implant Dent Relat Res, 2013, 15(4): 481-489.
[47] Manzano-Moreno FJ, Rodríguez-Martínez JB, Ramos-Torrecillas J, et al.Proliferation and osteogenic differentiation of osteoblast-like cells obtained from two techniques for harvesting intraoral bone grafts[J]. Clin Oral Investig, 2013, 17(5): 1349-1356.
[48] Sbordone C, Toti P, Guidetti F, et al.Volume changes of autogenous bone after sinus lifting and grafting procedures: a 6-year computerized tomographic follow-up[J]. J Craniomaxillofac Surg, 2013, 41(3): 235-241.
[49] Peng W, Kim IK, Cho HY, et al.Assessment of the autogenous bone graft for sinus elevation[J]. J Korean Assoc Oral Maxillofac Surg, 2013, 39(6): 274-282.
[50] Aludden HC, Mordenfeld A, Hallman M, et al.Lateral ridge augmentation with Bio-Oss alone or Bio-Oss mixed with particulate autogenous bone graft: a systematic review[J]. Int J Oral Maxillofac Surg, 2017, 46(8): 1030-1038.
[51] Mordenfeld A, Johansson CB, Albrektsson T, et al.A randomized and controlled clinical trial of two different compositions of deproteinized bovine bone and autogenous bone used for lateral ridge augmentation[J]. Clin Oral Implants Res, 2014, 25(3): 310-320.
[52] Khoury F, Hanser T.Three-dimensional vertical alveolar ridge augmentation in the posterior maxilla: a 10-year clinical study[J]. Int J Oral Maxillofac Implants, 2019, 34(2): 471-480.
[53] De Stavola L, Tunkel J.Results of vertical bone augmentation with autogenous bone block grafts and the tunnel technique: a clinical prospective study of 10 consecutively treated patients[J]. Int J Periodontics Restorative Dent, 2013, 33(5): 651-659.
[54] 尉华杰, 朱一博, 邱立新. 双层皮质骨片夹层植骨技术对上前牙重度骨缺损患者成骨效果的长期临床观察[J]. 中华口腔医学杂志, 2020, 55(11): 838-844.
Yu HJ, Zhu YB, Qiu LX.Clinical study on bilamina cortical grafting technique for reconstruction of severely atrophic alveolar ridges in anterior maxillae[J]. Chinese Journal of Stomatology, 2020, 55(11): 838-844.
[55] Soldatos NK, Stylianou P, Koidou VP, et al.Limitations and options using resorbable versus nonresorbable membranes for successful guided bone regeneration[J]. Quintessence Int, 2017, 48(2): 131-147.
[56] 胡文军, 朱靖恺, 马威. 植骨材料在口腔种植中的应用概况及进展[J]. 中国实用口腔科杂志, 2018, 11(1): 17-23.
Hu WJ, Zhu JK, Ma W.Application and progress of bone graft materials in oral implantation[J]. Chinese Journal of Practical Stomatology, 2018, 11(1): 17-23.
[57] 尉华杰, 邱立新. 块状及片状自体骨重建牙槽嵴重度骨缺损的临床研究[J]. 中国口腔种植学杂志, 2021, 26(1): 18-24.
Yu HJ, Qiu LX.Clinical study on the reconstruction of severe alveolar ridge bone defect with block and flake autogenous bone[J]. Chinese Journal of Oral Implantology, 2021, 26(1): 18-24.
[58] Giesenhagen B, Martin N, Donkiewicz P, et al.Vertical bone augmentation in a single-tooth gap with an allogenic bone ring: clinical considerations[J]. J Esthet Restor Dent, 2018, 30(6): 480-483.
[59] Sáez-Alcaide LM, Brinkmann JC, Sánchez-Labrador L, et al.Effectiveness of the bone ring technique and simultaneous implant placement for vertical ridge augmentation: a systematic review[J]. Int J Implant Dent, 2020, 6(1): 82-90.
[60] Giesenhagen B, Martin N, Jung O, et al.Bone augmentation and simultaneous implant placement with allogenic bone rings and analysis of its purification success[J]. Materials (Basel), 2019, 12(8): 1291.
[61] Amrani S, Anastassov GE, Montazem AH.Mandibular ramus/coronoid process grafts in maxillofacial reconstructive surgery[J]. J Oral Maxillofac Surg, 2010, 68(3): 641-646.
[62] Schlundt C, Fischer H, Bucher CH, et al.The multifaceted roles of macrophages in bone regeneration: a story of polarization, activation and time[J]. Acta Biomater, 2021, 133: 46-57.
[63] Sakkas A, Wilde F, Heufelder M, et al.Autogenous bone grafts in oral implantology-is it still a "gold standard"? a consecutive review of 279 patients with 456 clinical procedures[J]. Int J Implant Dent, 2017, 3(1): 23-40.
[64] Acocella A, Bertolai R, Colafranceschi M, et al.Clinical, histological and histomorphometric evaluation of the healing of mandibular ramus bone block grafts for alveolar ridge augmentation before implant placement[J]. J Craniomaxillofac Surg, 2010, 38(3): 222-230.
[65] Ataman-Duruel ET, Duruel O, Nares S, et al.Quantity and quality of intraoral autogenous block graft donor sites with cone beam computed tomography[J]. Int J Oral Maxillofac Implants, 2020, 35(4): 782-788.
[66] Chappuis V, Cavusoglu Y, Buser D, et al.Lateral ridge augmentation using autogenous block grafts and guided bone regeneration: a 10-year prospective case series study[J]. Clin Implant Dent Relat Res, 2017, 19(1): 85-96.
[67] Reininger D, Cobo-Vázquez C, Rosenberg B, et al.Alternative intraoral donor sites to the chin and mandibular body-ramus[J]. J Clin Exp Dent, 2017, 9(12): e1474-e1481.
[68] Dik EA, de Ruiter AP, van der Bilt A, et al. Effect on the contour of bone and soft tissue one year after harvesting chin bone for alveolar cleft repair[J]. Int J Oral Maxillofac Surg, 2010, 39(10): 962-967.
[69] 王连飞, 程刚. 骨环种植技术在口腔临床应用的研究进展[J]. 口腔材料器械杂志, 2020, 29(1): 46-49.
Wang LF, Cheng G.Research progress of bone ring implantation technology in oral clinical application[J]. Journal of Oral Materials and Instruments, 2020, 29(1): 46-49.
[70] Reininger D, Cobo-Vázquez C, Monteserín-Matesanz M, et al.Complications in the use of the mandibular body, ramus and symphysis as donor sites in bone graft surgery. a systematic review[J]. Med Oral Patol Oral Cir Bucal, 2016, 21(2): e241-e249.
[71] Zeltner M, Flückiger LB, Hämmerle CH, et al.Volumetric analysis of chin and mandibular retromolar region as donor sites for cortico-cancellous bone blocks[J]. Clin Oral Implants Res, 2016, 27(8): 999-1004.
[72] Verdugo F, Simonian K, Smith McDonald R, et al. Quantitation of mandibular ramus volume as a source of bone grafting[J]. Clin Implant Dent Relat Res, 2009, 11(Suppl 1): e32-e37.
[73] Starch-Jensen T, Deluiz D, Deb S, et al.Harvesting of autogenous bone graft from the ascending mandibular ramus compared with the chin region: a systematic review and meta-analysis focusing on complications and donor site morbidity[J]. J Oral Maxillofac Res, 2020, 11(3): e1.
[74] Carlsen A, Gorst-Rasmussen A, Jensen T.Donor site morbidity associated with autogenous bone harvesting from the ascending mandibular ramus[J]. Implant Dent, 2013, 22(5): 503-506.
[75] 赵雪竹, 唐志辉, 邹立东, 等. 下颌支区半柱状自体骨移植与颏部矩形自体骨移植在美学区水平向骨增量中的临床应用效果评价—随机对照临床试验[J]. 口腔医学研究, 2018, 34(9): 969-973.
Zhao XZ, Tang ZH, Zou LD, et al.Evaluation of clinical application of semi-columnar autograft and rectangular chin autograft in horizontal bone increment in the United States: a randomized controlled clinical trial[J]. Journal of Stomatology, 2018, 34(9): 969-973.
[76] Mertens C, Steveling HG, Seeberger R, et al.Reconstruction of severely atrophied alveolar ridges with calvarial onlay bone grafts and dental implants[J]. Clin Implant Dent Relat Res, 2013, 15(5): 673-683.
[77] Zufía J, Abella Sans F.Applications of maxillary tuberosity block autograft[J]. J Esthet Restor Dent, 2022, 34(7): 1015-1028.
[78] Singh S.Management of infrabony defects in mandibular molars in a patient with generalized aggressive periodontitis using autogenous bone graft from maxillary tuberosity[J]. J Indian Soc Periodontol, 2010, 14(1): 53-56.
[79] Wu V, Schulten E, Helder MN, et al.Bone vitality and vascularization of mandibular and maxillary bone grafts in maxillary sinus floor elevation: a retrospective cohort study[J]. Clin Implant Dent Relat Res, 2023, 25(1): 141-151.
[80] Guthua S, Ng'ang'a PM, Sarna K, et al. An innovative approach in the management of alveolar clefts with bone graft harvest from maxillary tuberosity and mandibular wisdom molar odontectomy sites: a case report[J]. Clin Case Rep, 2021, 9(12): e05253.
[81] Khojasteh A, Nazeman P, Tolstunov L.Tuberosity-alveolar block as a donor site for localised augmentation of the maxilla: a retrospective clinical study[J]. Br J Oral Maxillofac Surg, 2016, 54(8): 950-955.
[82] El Nahass H, Naiem SN.Palatal bone dimensions on cone beam computed tomography. Implications for the palate as autogenous donor site: an observational study[J]. Int J Oral Maxillofac Surg, 2016, 45(1): 99-103.
[83] 李清华, 郑海波, 朱亚琴, 等. 口腔种植术中腭部取骨量的CT测量研究[J]. 中国医学影像学杂志, 2013, 21(9): 697-700.
Li QH, Zheng HB, Zhu YQ, et al.CT measurement of palate bone extraction during oral implantation[J]. Chinese Journal of Medical Imaging, 2013, 21(9): 697-700.
[84] Hernández-Alfaro F, Pages CM, García E, et al.Palatal core graft for alveolar reconstruction: a new donor site[J]. Int J Oral Maxillofac Implants, 2005, 20(5): 777-783.
[85] Bernades Mayordomo R, Guijarro Martínez R, Hernández Alfaro F.The anterior maxilla as a potential source of bone grafts: a morphometric cone beam computed tomography analysis of different anatomical areas[J]. Int J Oral Maxillofac Surg, 2016, 45(8): 1049-1056.
[86] Yeung R.Simultaneous placement of implant and bone graft in the anterior maxilla: a case report[J]. Int J Oral Maxillofac Implants, 2004, 19(6): 892-895.
[87] Peñarrocha M, García-Mira B, Martinez O.Localized vertical maxillary ridge preservation using bone cores and a rotated palatal flap[J]. Int J Oral Maxillofac Implants, 2005, 20(1): 131-134.
[88] Wang T, Wu Q, Qu Y, et al.In-situ onlay grafting combined with titanium mesh for three-dimensional reconstruction of the anterior maxillary ridge[J]. Int J Periodontics Restorative Dent, 2016, 36(1): 95-101.
[89] Kainulainen VT, Sàndor GK, Oikarinen KS, et al.Zygomatic bone: an additional donor site for alveolar bone reconstruction. technical note[J]. Int J Oral Maxillofac Implants, 2002, 17(5): 723-728.
[90] Gellrich NC, Held U, Schoen R, et al.Alveolar zygomatic buttress: a new donor site for limited preimplant augmentation procedures[J]. J Oral Maxillofac Surg, 2007, 65(2): 275-280.
[91] 郭毅, 曹啟垣, 关崧华, 等. 智齿拔除术区自体块状骨在前牙区Onlay植骨术中的临床应用[J]. 口腔疾病防治, 2017, 25(9): 586-589.
Guo Y, Cao QH, Guan SH, et al.The clinical application of autogenous massive bone in anterior tooth area of wisdom tooth extraction[J]. Prevention and Treatment of Oral Diseases, 2017, 25(9): 586-589.
[92] Chang Y, Kim N, Stenfelt S.The development of a whole-head human finite-element model for simulation of the transmission of bone-conducted sound[J]. J Acoust Soc Am, 2016, 140(3): 1635.
[93] Chiapasco M, Zaniboni M, Boisco M.Augmentation procedures for the rehabilitation of deficient edentulous ridges with oral implants[J]. Clin Oral Implants Res, 2006, 17(Suppl 2): 136-159.
[94] Petrungaro PS, Amar S.Localized ridge augmentation with allogenic block grafts prior to implant placement: case reports and histologic evaluations[J]. Implant Dent, 2005, 14(2): 139-148.
[95] Wortmann DE, van Minnen B, Delli K, et al. Harvesting anterior iliac crest or calvarial bone grafts to augment severely resorbed edentulous jaws: a systematic review and meta-analysis of patient-reported outcomes[J]. Int J Oral Maxillofac Surg, 2023, 52(4): 481-494.
[96] Scheerlinck LM, Muradin MS, van der Bilt A, et al. Donor site complications in bone grafting: comparison of iliac crest, calvarial, and mandibular ramus bone[J]. Int J Oral Maxillofac Implants, 2013, 28(1): 222-227.
[97] 鞠远福, 陈美伦. 自体骨移植修复下颌骨缺损[J]. 皖南医学院学报, 1998, 17(4): 375-376.
Ju YF, Chen ML.Repair of mandibular defect with autogenous bone transplantation[J]. Journal of Wannan Medical College, 1998, 17(4): 375-376.
[98] Arabiun H, Bordbar H, Dehghani Nazhvani S, et al.Effects of different storage media, temperature, and time on osteoblast preservation in autogenous bone grafts: a histomorphometrical analysis[J]. J Dent (Shiraz), 2020, 21(3): 225-233.
[99] Hashemi HM, Beshkar M.Bacterial contamination of autogenous bone collected by rongeur compared with that collected by bone filter during implant surgery[J]. Br J Oral Maxillofac Surg, 2011, 49(6): 474-477.
[100] Liang C, Lin X, Wang SL, et al.Osteogenic potential of three different autogenous bone particles harvested during implant surgery[J]. Oral Dis, 2017, 23(8): 1099-1108.
[101] 成贤基, 叶俊, 刘雯雯, 等. 慢速法制备种植体窝洞原位取骨的临床研究[J]. 中国口腔种植学杂志, 2013, 18(1): 22-25.
Cheng XJ, Ye J, Liu WW, et al.Clinical study on the preparation of implant cavity in situ bone extraction by slow method[J]. Chinese Journal of Oral Implantology, 2013, 18(1): 22-25.
[102] 郑善川, 骆树瑜. 超声骨刀在微创拔牙中应用的研究进展[J]. 微创医学, 2023,18(5): 608-610, 633.
Zheng SC, Luo SY.Research progress of ultrasonic bone knife in minimally invasive tooth extraction[J]. Minimally Invasive Medicine, 2023, 18(5): 608-610, 633.
[103] 俞琼, 黄廷贲, 杨国利. 原位取骨技术在上前牙种植中的应用[J]. 口腔医学, 2021, 41(7): 649-653.
Yu Q, Huang TB, Yang GL.In-situ autogenous bone grafting technique in anterior maxilla[J]. Stomatology, 2021, 41(7): 649-653.
[104] Zhen F, Fang W, Jing S, et al.The use of a piezoelectric ultrasonic osteotome for internal sinus elevation: a retrospective analysis of clinical results[J]. Int J Oral Maxillofac Implants, 2012, 27(4): 920-926.
[105] Kämmerer PW, Al-Nawas B.Bone reconstruction of extensive maxillomandibular defects in adults[J]. Periodontol 2000, 2023, 93(1): 340-357.
[106] Cristoforetti A, De Stavola L, Fincato A, et al.Assessing the accuracy of computer-planned osteotomy guided by stereolithographic template: a methodological framework applied to the mandibular bone harvesting[J]. Comput Biol Med, 2019, 114: 103435.
[107] 周冬玲, 王友君, 黄震,等. 不同原位取骨方法的种植体植入精度和获得自体骨骨量的比较[J]. 现代口腔医学杂志, 2022, 36(4): 235-238.
Zhou DL, Wang YJ, Huang Z, et al.Comparison of implant implantation accuracy and bone amount obtained by different in situ bone extraction methods[J]. Journal of Modern Stomatology, 2002, 36(4): 235-238.