高活性骨替代材料在颌面部骨组织工程中的应用进展

doi:10.19438/j.cjoms.2024.04.013

摘要/Abstract

摘要： 颌骨缺损是口腔颌面外科最常见的疾病之一,严重颌骨缺损会对患者生活和心理造成不同程度的影响,需要进行及时有效的修复。颌骨具有的独特生理外形和个体差异,导致颌骨缺损的修复无法完全依赖于标准化的骨修复体。随着相关制造技术的发展和成熟,特别是3D打印技术在骨缺损修复方面具有的独特优势, 已引起国内外学者广泛关注。骨缺损修复是一个复杂而精密的过程,理想的修复骨缺损的生物材料应具备良好的组织相容性、合适的机械应力、适宜的孔径大小和溶解性等特性。本文简要综述了现有的用于颌骨组织工程的高活性骨替代材料。

关键词: 颌骨, 生物材料, 组织工程, 颌骨缺损, 3D打印

Abstract: Jaw defect is one of the most common diseases in oral and maxillofacial surgery. Severe jaw defect will cause different degrees of impact on the life and psychology of patients, and needs timely and effective repair. Due to the unique physiologic appearance and individual differences of jaw bones, the repair of jaw defects can't be completely dependent on standardized bone prosthetics. With the development and maturity of related manufacturing technologies, especially the unique advantages of 3D printing technology in bone defect repair, it has attracted wide attention of scholars both at home and abroad. The repair of bone defects is a complex and precise process. The ideal biomaterials for repairing bone defects should have good histocompatibility, suitable mechanical stress, suitable pore size, and solubility. This article briefly reviewed the existing high-active bone replacement materials for jaw tissue engineering.

Key words: Jaw, Biomaterials, Tissue engineering, Jaw defect, 3D printing

中图分类号:

R782.2

袁露函, 楚晨, 袁荣涛. 高活性骨替代材料在颌面部骨组织工程中的应用进展[J]. 中国口腔颌面外科杂志, 2024, 22(4): 394-399.

YUAN Lu-han, CHU Chen, YUAN Rong-tao. Research progress of application of highly active bone substitute in materialsmaxillofacial bone tissue engineering[J]. China J Oral Maxillofac Surg, 2024, 22(4): 394-399.

参考文献

[1] Zhang WB, Saxena S, Fakhrzadeh A, et al.Use of human dental pulp and endothelial cell seeded tyrosine-derived polycarbonate scaffolds for robust in vivo alveolar jaw bone regeneration[J]. Front Bioeng Biotechnol, 2020, 8: 796-807.
[2] Huang D, Li KD, Zheng XH, et al.Hyperbaric oxygen therapy: an effective auxiliary treatment method for large jaw cysts[J]. Int J Med Sci, 2021, 18(16): 3692-3696.
[3] Zhao J, Zhou YH, Zhao YQ, et al.Oral cavity-derived stem cells and preclinical models of jaw-bone defects for bone tissue engineering[J]. Stem Cell Res Ther, 2023,14(1): 39-59.
[4] 陈艺菲,郑赛男,阙林. 3D打印复合材料骨组织工程支架及其在颌面骨再生中的研究进展[J].山东医药, 2022, 62(25): 83-86.
Chen YF, Zheng SN, Que L.Research progress of 3D printed composite bone tissue engineering scaffold and its application in maxillofacial bone regeneration[J]. Shandong Medicine,2022, 62(25): 83-86.
[5] 王荷静, 张采欣, 寻兴祥, 等. 骨替代材料在上颌窦底外提升同期牙种植中促进骨再生的价值[J].中国口腔颌面外科杂志, 2023, 21(3): 218-224.
Wang HJ, Zhang CX, Xun XX, et al.The value of bone replacement materials in promoting bone regeneration in simultaneous dental implantation outside maxillary sinus[J]. China Journal of Oral and Maxillofacial Surgery, 2019, 21(3): 218-224.
[6] Chang S, Wang S, Liu Z, et al.Advances of stimulus-responsive hydrogels for bone defects repair in tissue engineering[J]. Gels, 2022, 8(6): 389-403.
[7] Mani MP, Sadia M, Jaganathan SK, et al.A review on 3D printing in tissue engineering applications[J]. J Polymer Eng, 2022, 42(3): 243-265.
[8] Wang C, Huang W, Zhou Y, et al.3D printing of bone tissue engineering scaffolds[J]. Bioact Mater, 2020,5(1): 82-91.
[9] Liao M, Zhu S, Guo A, et al.3D printed bioactive glasses porous scaffolds with high strength for the repair of long-bone segmental defects[J]. Compos B Eng, 2023,254: 110582.
[10] Zhou Y, Wu C, Chang J.Bioceramics to regulate stem cells and their microenvironment for tissue regeneration[J]. Mater Today Bio, 2019, 24: 41-56.
[11] Koons GL, Diba M, Mikos AG.Materials design for bone-tissue engineering[J]. Nat Rev Mater, 2020, 5(8): 584-603.
[12] 余文,孟昊业,孙逊,等. 3D打印生物陶瓷在骨组织工程中的研究现状[J].中国矫形外科杂志, 2018, 26(14): 1306-1310.
Yu W, Meng HY, Sun X, et al.3D printing porous ceramic scaffolds for bone tissue engineering: a review[J]. Orthopedic Journal of China, 2018,26(14): 1306-1310.
[13] 欧阳婉璐,钱玉芬.生物陶瓷材料负载冻干BMP-2对牙槽突裂骨改建的影响[J].中国口腔颌面外科杂志, 2018, 16(3): 221-226.
Ouyang WL, Qian YF.Effect of bioceramic materials loaded lyophilized BMP-2 on alveolar fracture bone remodeling[J]. China Journal of Oral and Maxillofacial Surgery, 2018, 16(3): 221-226.
[14] Cao CL, Huang PR, Prasopthum A, et al.Characterisation of bone regeneration in 3D printed ductile PCL/PEG/hydroxyapatite scaffolds with high ceramic microparticle concentrations[J]. Biomater Sci, 2021, 10(1): 138-152.
[15] Yang YJ, Kulkarni A, Soraru GD, et al.3D Printed SiOC(N) ceramic scaffolds for bone tissue regeneration: improved osteogenic differentiation of human bone marrow-derived mesenchymal stem cells[J]. Int J Mol Sci, 2021,22(24): 13676.
[16] Liu X, Zhao NR, Liang HF, et al.Bone tissue engineering scaffolds with HUVECs/hBMSCs cocultured on 3D-printed composite bioactive ceramic scaffolds promoted osteogenesis/angiogenesis[J]. J Orthop Translat, 2022, 37: 152-162.
[17] 林嘉宜, 袁伟壮, 张洪武. 医用3D打印材料应用于骨缺损修复的研究进展[J].中国临床解剖学杂志, 2017, 35(6): 708-712.
Lin JY, Yuan WZ, Zhang HW.Research progress of medical 3D printing materials for bone defect repair[J]. Chinese Journal of Clinical Anatomy, 2017, 35(6): 708-712.
[18] Im S, Choe G, Seok JM, et al.An osteogenic bioink composed of alginate, cellulose nanofibrils, and polydopamine nanoparticles for 3D bioprinting and bone tissue engineering[J]. Int J Biol Macromol, 2022,205:520-529.
[19] Wang HP, Cui JY, Li ST, et al.Fabrication of functional and biodegradable scaffolds using nucleated poly (4-hydroxybutyrate) via 3D printing for bone tissue engineering[J]. Polym Test, 2023, 118: 107881.
[20] Hassan MN, Yassin MA, Eltawila AM, et al.Contact osteogenesis by biodegradable 3D-printed poly(lactide-co-trimethylene carbonate)[J]. Biomater Res, 2022,26(1): 55-74.
[21] Lewns FK, Tsigkou O, Cox LR, et al.Hydrogels and bioprinting in bone tissue engineering: creating artificial stem-cell niches for in vitro models[J]. Adv Mater, 2023, 35(52): e2301670.
[22] 任荣, 张剑飞, 司家文, 等. 海藻酸钠/明胶复合水凝胶用于3D生物打印的初步研究[J].中国口腔颌面外科杂志, 2017,15(5): 402-407.
Ren R, Zhang JF, Si JW, et al.Preliminary study of sodium alginate/gelatin composite hydrogel for 3D bioprint[J]. China Journal of Oral and Maxillofacial Surgery, 2017,15(5): 402-407.
[23] Zou Q, Tian XB, Luo SW, et al.Agarose composite hydrogel and PVA sacrificial materials for bioprinting large-scale, personalized face-like with nutrient networks[J]. Carbohydr Polym, 2021,269: 118222.
[24] Hernandez I, Kumar A, Joddar B.A Bioactive hydrogel and 3D printed polycaprolactone system for bone tissue engineering[J]. Gels, 2017,3(3): 26-39.
[25] Rajabi M, Cabral JD, Saunderson S, et al.3D printing of chitooligosaccharide-polyethylene glycol diacrylate hydrogel inks for bone tissue regeneration[J]. J Biomed Mater Res A, 2023, 111(9): 1468-1481.
[26] van der Heide D, Cidonio G, Stoddart MJ, et al. 3D printing of inorganic-biopolymer composites for bone regeneration[J]. Biofabrication, 2022,14(4): e042003.
[27] Han YT, Wei QQ, Chang PB, et al.Three-dimensional printing of hydroxyapatite composites for biomedical application[J]. Crystals, 2021,11(4): 353.
[28] Gang FL, Ye WL, Ma CY, et al.3D printing of PLLA/biomineral composite bone tissue engineering scaffolds[J]. Materials(Basel), 2022,15(12): 4280-4295.
[29] Cakmak AM, Unal S, Sahin A, et al.3D printed polycaprolactone/gelatin/bacterial cellulose/hydroxyapatite composite scaffold for bone tissue engineering[J]. Polymers(Basel), 2020, 12(9): 1962-1976.
[30] Distler T, Fournier N, Grünewald A, et al.Polymer-bioactive glass composite filaments for 3D scaffold manufacturing by fused deposition modeling: fabrication and characterization[J]. Front Bioeng Biotechnol, 2020, 8: 552-568.
[31] Najafabadi FM, Karbasi S, Benisi SZ, et al.Physical, mechanical, and biological performance of chitosan-based nanocomposite coating deposited on the polycaprolactone-based 3D printed scaffold: Potential application in bone tissue engineering[J]. Int J Biol Macromol, 2023, 243: 125218.
[32] Petretta M, Gambardella A, Desando G, et al.Multifunctional 3D-printed magnetic polycaprolactone/hydroxyapatite scaffolds for bone tissue engineering[J]. Polymers(Basel), 2021, 13(21): 3825-3840.