去泛素化酶在口腔鳞癌中的研究进展

doi:10.19438/j.cjoms.2024.03.015

摘要/Abstract

摘要： 口腔鳞状细胞癌（oral squamous cell carcinoma,OSCC）是头颈部最常见的恶性肿瘤之一,由于发病部位的特殊性而引起口腔功能障碍和面容破坏,预后较差,5年生存率尚不足50%,其发生、发展涉及多种信号通路调控。泛素及去泛素化是蛋白质翻译后修饰中关键的调控机制之一,越来越多的研究发现,去泛素化相关的酶在OSCC相关信号通路的调控中发挥着重要作用。本文总结去泛素化酶在OSCC不同信号通路中的调控机制,为去泛素化酶在OSCC中的研究提供依据。

关键词: 口腔鳞状细胞癌, 去泛素化酶, P53-MDM2, Wnt/β-catenin, NF-κB, Hedgehog

Abstract: Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in head and neck cancers. Due to the unique location of its onset, it can cause dysfunction of the oral cavity and facial damage, resulting in poor prognosis. The 5-year survival rate is still less than 50%. Its occurrence and development are regulated by multiple signaling pathways. Ubiquitination and deubiquitination are one of the key regulatory mechanisms in protein post translational modifications. More and more studies have found that deubiquitinating enzymes play an important role in the regulation of OSCC related signaling pathways. This article summarized the regulatory mechanisms of deubiquitinating enzymes in different signaling pathways of OSCC, providing a basis for the research of deubiquitinating enzymes in OSCC.

Key words: Oral squamous cell carcinoma, Deubiquitinating enzymes, P53-MDM2, Wnt/β-catenin, NF-κB, Hedgehog

中图分类号:

R739.8

孙晓梅, 段晓峰. 去泛素化酶在口腔鳞癌中的研究进展[J]. 中国口腔颌面外科杂志, 2024, 22(3): 294-299.

SUN Xiao-mei, DUAN Xiao-feng. Research progress of deubiquitinase in oral squamous cell carcinoma[J]. China J Oral Maxillofac Surg, 2024, 22(3): 294-299.

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