丙酮酸激酶M2与CD276在头颈鳞癌中的表达及临床意义

doi:10.19438/j.cjoms.2020.04.002

中国口腔颌面外科杂志 ›› 2020, Vol. 18 ›› Issue (4): 297-301.doi: 10.19438/j.cjoms.2020.04.002

丙酮酸激酶M2与CD276在头颈鳞癌中的表达及临床意义

常涵月^1,2, 马海龙², 杨溪^2,*, 张志愿^1,2,*

1.广州医科大学附属口腔医院,广州口腔疾病研究所·口腔医学重点实验室,广东广州 510140;
2.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011

收稿日期:2019-11-28 出版日期:2020-07-20 发布日期:2020-09-10
通讯作者: 张志愿,E-mail: zhzhy0502@163.com;杨溪,E-mail: yangxi16@163.com。^*共同通信作者
作者简介:常涵月（1995-）,女,在读硕士研究生,E-mail:changhy95@163.com
基金资助:
国家自然科学基金（81902747,81602367）

Expression and significance of pyruvate kinase M2 and CD276 in head and neck squamous cell carcinoma

CHANG Han-yue^1,2, MA Hai-long², YANG Xi², ZHANG Zhi-yuan^1,2

1. Key Laboratory of Oral Medicine, Guangzhou Institute of Oral Disease, Stomatology Hospital of Guangzhou Medical University. Guangzhou 510140, Guangdong Province;
2. Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Disease; Shanghai Key Laboratory of Stomatology & Shanghai Reasearch Institute of Stomatology. Shanghai 200011, China

Received:2019-11-28 Online:2020-07-20 Published:2020-09-10

摘要/Abstract

摘要： 目的: 观察丙酮酸激酶M2（pyruvate kinase M2,PKM2）和B7H3（CD276）在头颈鳞癌（head and neck squamous cell carcinoma,HNSCC）和正常口腔黏膜中的表达,探讨PKM2与CD276的相关性。方法: 应用免疫组织化学方法检测PKM2和CD276在70例HNSCC及18例正常口腔黏膜组织中的表达水平,分析PKM2和CD276的表达水平与HNSCC临床病理特征的关系。采用SPSS 13.0软件包对数据进行统计学分析。结果: PKM2和CD276在HNSCC 的表达水平比正常黏膜组织高。PKM2和CD276的表达水平与TNM分期相关（P<0.05）,与患者性别、年龄、病理分级无相关性（P>0.05）。CD276在头颈鳞癌中的表达与PKM2的表达呈正相关。结论: PKM2和CD276在HNSCC的高表达与肿瘤恶性进展相关。PKM2可能通过增加CD276的表达而参与免疫调控。

关键词: 丙酮酸激酶M2, CD276, 头颈鳞癌

Abstract: PURPOSE: To investigate the expression and correlation between pyruvate kinase M2 (PKM2) and B7H3 (CD276) in head and neck squamous cell carcinoma (HNSCC) patients. METHODS: Immunohistochemical staining was used to detect the expression of PKM2 and CD276 in 70 HNSCC tissues and 18 normal oral mucosa tissues. The relationship between the expression of PKM2 and CD276 in OSCC tissues and clinical pathological characteristics were analyzed using SPSS13.0 software package. RESULTS: The expression of PKM2 and CD276 in HNSCC was significantly higher than that in normal oral mucosa. The expression of PKM2 and CD276 was strongly associated with TNM stage (P<0.05), while no correlation with gender, age, pathological differentiation grade(P>0.05). The expression of CD276 was positively correlated with the expression of PKM2 in HNSCC. CONCLUSIONS: High expression of PKM2 and CD276 in HNSCC was closely related with malignant progression, and PKM2 may participate in immune regulation by promoting CD276 expression.

Key words: Pyruvate kinase M2, CD276, head and neck squamous cell carcinoma

中图分类号:

R739.8

常涵月, 马海龙, 杨溪, 张志愿. 丙酮酸激酶M2与CD276在头颈鳞癌中的表达及临床意义[J]. 中国口腔颌面外科杂志, 2020, 18(4): 297-301.

CHANG Han-yue, MA Hai-long, YANG Xi, ZHANG Zhi-yuan. Expression and significance of pyruvate kinase M2 and CD276 in head and neck squamous cell carcinoma[J]. China J Oral Maxillofac Surg, 2020, 18(4): 297-301.

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丙酮酸激酶M2与CD276在头颈鳞癌中的表达及临床意义

Expression and significance of pyruvate kinase M2 and CD276 in head and neck squamous cell carcinoma

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