13 649例中国东南部地区腮腺肿瘤构成比分析

doi:10.19438/j.cjoms.2024.06.012

中国口腔颌面外科杂志 ›› 2024, Vol. 22 ›› Issue (6): 590-596.doi: 10.19438/j.cjoms.2024.06.012

13 649例中国东南部地区腮腺肿瘤构成比分析

顾挺, 孙晶晶, 王瑜, 田臻, 王丽珍, 胡宇华, 夏荣辉, 李江, 张春叶

上海交通大学医学院附属第九人民医院口腔病理科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,中国医学科学院口腔颌面再生医学创新单元,上海 200011

收稿日期:2023-10-23 修回日期:2024-05-13 出版日期:2024-11-20 发布日期:2024-12-11
通讯作者: 张春叶,E-mail：yezi1806@126.com
作者简介:顾挺（1981-）,男,硕士,主管技师,E-mail：yuemachun@126.com
基金资助:
国家自然科学基金（82141108,82103405); 上海交通大学医学院附属第九人民医院临床研究助推计划 (JYLJ202119)

Clinical analysis of 13 649 cases of parotid gland tumors in southeast China

GU Ting, SUN Jing-jing, WANG Yu, TIAN Zhen, WANG Li-zhen, HU Yu-hua, XIA Rong-hui, LI Jiang, ZHANG Chun-ye

Department of Oral Pathology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences. Shanghai 200011, China

Received:2023-10-23 Revised:2024-05-13 Online:2024-11-20 Published:2024-12-11

摘要/Abstract

摘要： 目的： 分析腮腺内肿瘤的病理类型及构成比,为流行病学提供数据支持。方法： 收集2005年1月—2022年12月上海交通大学医学院附属第九人民医院口腔病理科确诊为腮腺内的肿瘤病例,分析患者性别、年龄、病理类型等特点。结果： 共收集13 649例腮腺内肿瘤病例。患者年龄1~104岁,高峰年龄51~60岁,男女之比为1.3∶1。其中,良性11 008例（80.7%）,中间型/恶性2 641例（19.3%）。上皮源性肿瘤12 856例（94.2%）,软组织肿瘤454例（3.3%）,淋巴造血系统来源肿瘤339例（2.5%）。原发唾液腺肿瘤12 228例,其中恶性占15.9%（1 939/12 228）,良性占84.1%（10 289/12 228）。多形性腺瘤和癌在多形性腺瘤中分别是良、恶性肿瘤最常见的类型,转移性肿瘤以鼻咽淋巴上皮癌转移至腮腺最常见;神经鞘膜瘤是最常见的软组织肿瘤,黏膜相关淋巴组织结外边缘区淋巴瘤是腮腺淋巴造血系统肿瘤中最常见的肿瘤类型。结论： 中国东南部地区腮腺内肿瘤,多形性腺瘤和癌在多形性腺瘤中是最常见的良、恶性肿瘤,神经鞘膜瘤和MALT淋巴瘤分别是最常见的软组织肿瘤和淋巴造血系统肿瘤。

关键词: 腮腺肿瘤, 肿瘤构成, 流行病学, 中国东南部

Abstract: PURPOSE: To analyze the pathological types and composition ratios of tumors within the parotid gland in order to provide data for epidemiological support. METHODS: Patients diagnosed with parotid tumors were recruited from Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine between 2005 to 2022. The patient sex, age and tumor type were collected. RESULTS: Totally 13 649 cases were enrolled in this study. The patients’ age ranged from 1 to 104 years, with the peak age occurring in the sixth decade. The male to female ratio was 1.3∶1. Among of them, totally 11 008 were benign tumors (80.7%), and 2 641(19.3%) were intermediate/malignant tumors. A total of 12 856 cases (94.2%) originated from epithelium, while 454 cases (3.3%) from soft tissues and 339 cases (2.5%) from haematopoietic and lymphoid tissues. Among 12 228 cases of primary salivary gland tumors, totally 10 289 (84.1%) of them were benign and 1 939(15.9%) were malignant. Pleomorphic adenoma and carcinoma ex pleomorphic adenoma were the most common benign and malignant subtype, respectively. Nasopharyngeal lymphoepithelial carcinoma was the most prevalent among different types of metastatic tumors to the parotid gland. The most common soft tissue and haematopoietic and lymphoid tissue tumor in the parotid gland were Schwannoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue lymphoma(MALT lymphoma). CONCLUSIONS: In southeastern region of China, parotid tumors, pleomorphic adenoma and carcinoma ex pleomorphic adenoma are the most common benign and malignant tumors of the parotid gland. The most prevalent soft tissue tumors and lymphoid hematopoietic system tumors are Schwannoma and MALT lymphoma, respectively.

Key words: Parotid gland tumor, Tumor composition, Epidemiology, Southeastern region of China

中图分类号:

R739.8

顾挺, 孙晶晶, 王瑜, 田臻, 王丽珍, 胡宇华, 夏荣辉, 李江, 张春叶. 13 649例中国东南部地区腮腺肿瘤构成比分析[J]. 中国口腔颌面外科杂志, 2024, 22(6): 590-596.

GU Ting, SUN Jing-jing, WANG Yu, TIAN Zhen, WANG Li-zhen, HU Yu-hua, XIA Rong-hui, LI Jiang, ZHANG Chun-ye. Clinical analysis of 13 649 cases of parotid gland tumors in southeast China[J]. China J Oral Maxillofac Surg, 2024, 22(6): 590-596.

参考文献

[1] Maahs GS, Oppermann Pde O, Maahs LG, et al.Parotid gland tumors: a retrospective study of 154 patients[J]. Braz J Otorhinolaryngol, 2015, 81(3): 301-306.
[2] Shashinder S, Tang IP, Velayutham P, et al.A review of parotid tumours and their management: a ten-year-experience[J]. Med J Malaysia, 2009, 64(1): 31-33.
[3] Sungur N, Akan IM, Ulusoy MG, et al.Clinicopathological evaluation of parotid gland tumors: a retrospective study[J]. J Craniofac Surg, 2002, 13(1): 26-30.
[4] Ascani G, Pieramici T, Messi M, et al.Salivary glands tumours: a retrospective study of 454 patients[J]. Minerva Stomatol, 2006, 55(4): 209-214.
[5] Tian Z, Li L, Wang L, et al.Salivary gland neoplasms in oral and maxillofacial regions: a 23-year retrospective study of 6 982 cases in an eastern Chinese population[J]. Int J Oral Maxillofac Surg, 2010, 39(3): 235-242.
[6] EI-Naggar AK, Chan JKC, Grandis JR, et al.WHO classification of head and neck tumours[M]. 4th Ed. Lyon: IARC, 2017.
[7] Badlani J, Gupta R, Smith J, et al.Metastases to the parotid gland-a review of the clinicopathological evolution, molecular mechanisms and management[J]. Surg Oncol, 2018, 27(1): 44-53.
[8] Sun J, Wang L, Tian Z, et al.Higher Ki67 index, nodal involvement, and invasive growth were high risk factors for worse prognosis in conventional mammary analogue secretory carcinoma[J]. J Oral Maxillofac Surg, 2019, 77(6): 1187-1202.
[9] Zhang C, Gu T, Hu Y, et al.Reevaluation of salivary lymphadenoma: a subgroup identified as warthin-like mucoepidermoid carcinoma following molecular investigation for MAML2 rearrangement[J]. Arch Pathol Lab Med, 2021, 145(6): 744-752.
[10] 张亮, 张莉, 刘华, 等. 312 例腮腺区肿瘤临床回顾性分析[J]. 临床口腔医学杂志, 2022, 38(9): 534-537.
Zhang L, Zhang L, Liu H, et al.Retrospective clinical analysis of parotid gland tumor in 312 patients[J]. Journal of Clinical Stomatology, 2022, 38(9): 534-537.
[11] 庞亚倩, 张凯, 刘姗姗,等. 344 例腮腺肿瘤回顾性分析[J]. 齐齐哈尔医学院学报, 2020, 41(24): 3111-3115.
Pang YQ, Zhang K, Liu SS, et al.Retrospective analysis of 344 cases of parotid gland tumors[J]. Journal of Qiqihar Medical University, 2020, 41(24): 3111-3115.
[12] 赵志国, 高丹, 王瑾, 等. 896例腮腺肿瘤临床回顾分析[J]. 上海口腔医学, 2017, 26(6): 605-609.
Zhao ZG, Gao D, Wang J, et al.Retrospective analysis of 896 cases of parotid gland tumor[J]. Shanghai Journal of Stomatology, 2017, 26(6): 605-609.
[13] Drivas EI, Skoulakis CE, Symvoulakis EK, et al. Pattern of parotid gland tumors on Crete, Greece: a retrospective study of 131 cases[J]. Med Sci Monit, 2007, 13(3): CR136-140.
[14] Venkatesh S, Srinivas T, Hariprasad S.Parotid gland tumors: 2-year prospective clinicopathological study[J]. Ann Maxillofac Surg, 2019, 9(1): 103-109.
[15] Li LJ, Li Y, Wen YM, et al.Clinical analysis of salivary gland tumor cases in West China in past 50 years[J]. Oral Oncol, 2008, 44(2): 187-192.
[16] 邓明辉, 吴汉江. 湖南地区5 443 例口腔颌面部恶性肿瘤临床分析[J]. 中国口腔颌面外科杂志, 2010, 8(2): 144-148.
Deng MH, Wu HJ.Clinical analysis of 5 443 malignant oral and maxillofacial tumors in Hunan area[J]. China Journal of Oral and Maxillofacial Surgery, 2010, 8(2): 144-148.
[17] 罗志强, 南晓梅, 叶钟泰. 2 085例口腔颌面部肿瘤疾病构成比分析[J]. 国际口腔医学杂志, 2015, 42(6): 635-639.
Luo ZQ, Nan XM, Ye ZT.Analysis of the proportion of oral-maxillofacial tumors in 2 085 patients[J]. International Journal of Stomatology, 2015, 42(6): 635-639.
[18] Skálová A, Vanecek T, Sima R, et al.Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity[J]. Am J Surg Pathol, 2010, 34(5): 599-608.
[19] Alves LDB, de Melo AC, Farinha TA, et al. A systematic review of secretory carcinoma of the salivary gland: where are we?[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2021, 132(4): e143-e152.
[20] McCarthy WA, Cox BL. Intraparotid schwannoma[J]. Arch Pathol Lab Med, 2014, 138(7): 982-985.
[21] Gu T, Zhang C, Xia R, et al.Indicators for malignant transformation in patients with lymphoepithelial lesion[J]. J Oral Maxillofac Surg, 2021, 79(4): 836-844.
[22] Zhang C, Xia R, Gu T, et al.Clinicopathological aspects of primary mucosa-associated lymphoid tissue lymphoma of the salivary gland: a retrospective single-center analysis of 72 cases[J]. J Oral Pathol Med, 2021, 50(7): 723-730.

13 649例中国东南部地区腮腺肿瘤构成比分析

Clinical analysis of 13 649 cases of parotid gland tumors in southeast China

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