塞来昔布用于下颌阻生牙拔除术后镇痛的疗效评价

中国口腔颌面外科杂志 ›› 2014, Vol. 12 ›› Issue (1): 65-68.

塞来昔布用于下颌阻生牙拔除术后镇痛的疗效评价

王飞^{1, *}, 宇文婷^{2, *}, 梁衍灿², 程慧琳², 焦九阳², 鲁颖娟², 陈伟良²

1.中山大学孙逸仙纪念医院麻醉科, 广东广州 510120; 2.中山大学孙逸仙纪念医院口腔科,广东广州 510120

收稿日期:2012-05-20 修回日期:2012-07-16 出版日期:2014-02-10 发布日期:2014-02-10
通讯作者: 陈伟良,E-mail:drchen@vip.163.com
作者简介:王飞(1976-),男,硕士,主治医师,E-mail：1995wangfei@sina.com；宇文婷(1983-),女,学士,医师,E-mail:yuwenting2002@163.com。*并列第一作者
基金资助:
广东省科技社会发展项目(2012B031800374)

Application of celecoxib in analgesia for patients who underwent extraction of impacted tooth

WANG Fei¹, YU Wen-ting², LIANG Yan-can², CHENG Hui-lin², JIAO Jiu-yang², LU Ying-juan², CHEN Wei-liang²

1.Department of Anaesthesiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province, China; 2.Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. Guangzhou 510120, Guangdong Province, China

Received:2012-05-20 Revised:2012-07-16 Online:2014-02-10 Published:2014-02-10
Supported by:
Supported by Science and Techology Program of Guangdong Province (2012B031800374).

摘要/Abstract

摘要： 目的: 评价塞来昔布对下颌阻生牙拔除术后急性疼痛的镇痛效果。方法：90例拔除下颌阻生第三磨牙的患者按随机双盲法分为塞来昔布组、布洛芬组、安慰剂组,每组30例。拔牙4 h后,分别给予塞来昔布400 mg、布洛芬400 mg、维生素C 100 mg。采用视觉模拟评分法(visual analogue scale,VAS),记录患者拔牙4 h后、服药24 h内的疼痛情况及不良反应,利用SPSS 13.0软件包,通过χ²检验和方差分析,比较2种药物的镇痛效果有无显著差异。结果:塞来昔布组、布洛芬组与安慰剂组相比,在镇痛药起效时间、疼痛强度差值(PID)、疼痛缓解程度(PAR)、总疼痛强度差(SPID)、疼痛缓解总和(TOPPAR)、整体评价方面具有显著差异(P<0.05)。塞来昔布组与布洛芬组相比,镇痛效果基本相同,仅服药12 h后两者的PID有显著差异(P<0.05)。服药24 h内,在镇痛起效时间、PAR、SPID、TOPPAR、整体评价方面的差异无显著性(P>0.05)。结论：塞来昔布对下颌阻生牙拔除术后中、重度急性疼痛有明显的镇痛作用。

关键词: 塞来昔布, 阻生牙, 拔牙, 镇痛

Abstract: PURPOSE: To evaluate the effect of celecoxib in acute pain relief after extraction of impacted tooth. METHODS: In the randomized, double-blind placebo-controlled trial, 90 patients who underwent extraction of impacted mandibular third molar, were divided into 3 groups based on the use of ccelecoxib, ibuprofen and placebo. Each group had 30 patients. After 4 hours of extraction, patients were given 400 mg celecoxib in the celecoxib group, 400 mg ibuprofen in the ibuprofen group. While in the placebo group, 100 mg vitamin C was administrated. Pain and adverse events were recorded after extraction and application of 3 drugs. Chi-square test and analysis of variance were carried out for comparison between the three groups using SPSS 13.0 software package. RESULTS: There were significant differences in analgesic onset time, PID, PAR, SPID, TOPPAR and overall assessment between celecoxib group, ibuprofen and placebo group (P<0.05). Compared with celecoxib group and ibuprofen group, the analgesic effect was quite the same. 12 h after administration, only the PID of the two groups had significant difference (P<0.05). Within 24 h, there was no significant difference in time to onset of analgesia, PAR, SPID, TOPPAR, and overall assessment (P>0.05). CONCLUSIONS: Celecoxib has distinct analgesic effect in extraction of impacted teeth with acute severe pain.

Key words: Celecoxib, Impacted tooth, Extraction, Analgesia

王飞, 宇文婷, 梁衍灿, 程慧琳, 焦九阳, 鲁颖娟, 陈伟良. 塞来昔布用于下颌阻生牙拔除术后镇痛的疗效评价[J]. 中国口腔颌面外科杂志, 2014, 12(1): 65-68.

WANG Fei, YU Wen-ting, LIANG Yan-can, CHENG Hui-lin, JIAO Jiu-yang, LU Ying-juan, CHEN Wei-liang. Application of celecoxib in analgesia for patients who underwent extraction of impacted tooth[J]. China J Oral Maxillofac Surg, 2014, 12(1): 65-68.

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