柱状胶原蛋白海绵用于阻生牙拔除的效果及并发症风险分析

doi:10.19438/j.cjoms.2023.02.008

中国口腔颌面外科杂志 ›› 2023, Vol. 21 ›› Issue (2): 146-151.doi: 10.19438/j.cjoms.2023.02.008

柱状胶原蛋白海绵用于阻生牙拔除的效果及并发症风险分析

王辰昕^*, 彭晶^*, 黄昕, 施乐, 戴小锋

上海市静安区牙病防治所,上海 200070

收稿日期:2022-11-14 修回日期:2022-12-25 出版日期:2023-03-20 发布日期:2023-06-12
通讯作者: 戴小锋,E-mail: xiaofengdai2008@163.com
作者简介:王辰昕（1992- ）,女,硕士,主治医师,E-mail: wangchenxin_kjj@126.com;彭晶（1981-）,女,本科,主治医师,E-mail: yafangsuoywk@163.com。<sup>*</sup>并列第一作者
基金资助:
上海市静安区科学技术委员会、上海市静安区卫生健康委员会青年项目（2019QN13）

Effect of columnar collagen sponge on the extraction of impacted teeth and the risk of complications

WANG Chen-xin, PENG Jing, HUANG Xin, SHI Le, DAI Xiao-feng

Shanghai Jing'an Dental Clinic. Shanghai 200070, China

Received:2022-11-14 Revised:2022-12-25 Online:2023-03-20 Published:2023-06-12

摘要/Abstract

摘要： 目的： 探讨柱状胶原蛋白海绵用于阻生牙拔除的效果及并发症风险。方法： 选择2021年6月—2021年12月在上海市静安区牙病防治所实施阻生牙拔除的患者160例,随机分为试验组与对照组,每组各80例。2组均行常规阻生牙拔除术,对照组在牙拔除后使用20 mL氯化钠溶液冲洗患处牙窝;试验组在对照组基础上将柱状胶原蛋白海绵置入拔牙创面内。比较两组出血情况、术后疼痛评分、术后7 d肿胀程度、治疗前后龈沟液炎症因子水平[前列腺素E2（PGE2）、髓过氧化物酶（MPO）、降钙素基因相关肽（CGRP）]及术后并发症（开口受限、颌面部局部炎性硬结或淤青情况、感染、干槽症）发生情况。采用SPSS 22.0软件包对数据进行统计学分析。结果： 试验组患者术后出血时间显著低于对照组（P<0.05）,自发痛、吞咽痛VAS评分显著低于对照组（P<0.05）,患者拔牙7 d后肿胀程度显著低于对照组（P<0.05）;2组治疗前PGE2、MPO、CGRP比较无差异（P>0.05）,治疗后PGE2、MPO、CGRP均显著升高（P<0.05）,试验组显著低于对照组（P<0.05）;试验组患者术后并发症发生率显著低于对照组（P<0.05）。结论： 柱状胶原蛋白海绵用于阻生牙拔除效果较好,可有效避免术后并发症发生,对龈沟液炎症因子的影响较小,值得临床应用。

关键词: 柱状胶原蛋白海绵, 阻生智牙, 阻生牙拔除术, 并发症, 龈沟液炎症因子

Abstract: PURPOSE: To investigate the effect of collagen sponge in the extraction of impacted teeth and the risk of complications. METHODS: A total of 160 patients with impacted teeth extraction were selected from June 2021 to December 2021 in Shanghai Jing'an Dental Clinic. The patients were randomly divided into experimental group and control group, 80 cases in each group. Both groups underwent conventional extraction of impacted teeth, and the control group was rinsed with 20 mL sodium chloride solution after extraction. In the experimental group, on the basis of the control group, columnar collagen sponge was inserted into the extraction wound. Bleeding, postoperative pain score, postoperative swelling degree 7 days after surgery, levels of inflammatory factors[prostaglandin E2(PGE2), myeloperoxidase(MPO), calcitonin gene-related peptide(CGRP)] in gingival crevicular fluid before and after treatment and postoperative complications (restricted opening, inflammatory induration or bruising of maxillofacial region, infection, dry socket) were compared between the two groups. SPSS 22.0 software package was used for data analysis. RESULTS: The postoperative bleeding time of the experimental group was significantly lower than that of the control group(P<0.05). The VAS scores of spontaneous pain and dysphagia in the experimental group were significantly lower than those of the control group(P<0.05). The swelling degree of experimental group was significantly lower than that of control group 7 days after tooth extraction(P<0.05). There was no difference in PGE2, MPO and CGRP between the two groups before treatment(P>0.05). After treatment, PGE2, MPO and CGRP in the two groups were significantly increased(P<0.05), PGE2, MPO and CGRP of the experimental group after treatment were significantly lower than those of the control group after treatment(P<0.05). The incidence of postoperative complications in the experimental group was significantly lower than that in the control group (P<0.05). CONCLUSIONS: Columnar collagen sponge has a good effect in extraction of impacted teeth, and can effectively avoid postoperative complications, and has little influence on inflammatory factors in gingival crevicular fluid, which is worthy of wide application.

Key words: Columnar collagen sponge, Impacted wisdom teeth, Extraction of impacted teeth, Complications, Gingival crevicular fluid inflammatory factors

中图分类号:

R782.1

王辰昕, 彭晶, 黄昕, 施乐, 戴小锋. 柱状胶原蛋白海绵用于阻生牙拔除的效果及并发症风险分析[J]. 中国口腔颌面外科杂志, 2023, 21(2): 146-151.

WANG Chen-xin, PENG Jing, HUANG Xin, SHI Le, DAI Xiao-feng. Effect of columnar collagen sponge on the extraction of impacted teeth and the risk of complications[J]. China J Oral Maxillofac Surg, 2023, 21(2): 146-151.

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柱状胶原蛋白海绵用于阻生牙拔除的效果及并发症风险分析

Effect of columnar collagen sponge on the extraction of impacted teeth and the risk of complications

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