中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2026, Vol. 24 ›› Issue (3): 266-271.doi: 10.19438/j.cjoms.2026.03.010

• 论著 • 上一篇    下一篇

龈沟液leptin、HMGB1、SIRT1与种植体周炎的相关性及其对预后的预测价值

魏子程, 董煜, 侯德强, 李昕, 丁壮   

  1. 江南大学附属医院 口腔科,江苏 无锡 214122
  • 收稿日期:2025-08-29 修回日期:2025-12-03 出版日期:2026-05-20 发布日期:2026-06-04
  • 通讯作者: 魏子程,E-mail: wrn7i9d@163.com
  • 作者简介:魏子程（1986—）,男,硕士,副主任医师
  • 基金资助:
    无锡市科教兴卫工程-医学青年人才资助项目（QNRC058）

Correlation of Leptin, HMGB1, and SIRT1 in gingival crevicular fluid with peri-implantitis and their predictive value for prognosis

Wei Zicheng, Dong Yu, Hou Deqiang, Li Xin, Ding Zhuang   

  1. Department of Stomatology, Affiliated Hospital of Jiangnan University. Wuxi 214122, Jiangsu Province, China
  • Received:2025-08-29 Revised:2025-12-03 Online:2026-05-20 Published:2026-06-04

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摘要： 目的: 探讨龈沟液瘦素（leptin）、高迁移率族蛋白 B1（HMGB1）、沉默信息调节因子 1（SIRT1）与种植义齿修复患者并发种植体周炎（PI）的相关性,以及三者对预后不良的预测价值。方法: 选取2020年7月—2024年7月江南大学附属医院收治的295例种植义齿修复患者,其中61例确诊PI（PI组）,234例种植体健康（非PI组）。采用ELISA法检测龈沟液leptin、HMGB1、SIRT1水平,采用Pearson法分析三者与菌斑指数（PLI）、龈沟出血指数（SBI）、探诊深度（PD）的相关性,采用受试者工作特征（ROC）曲线评估三者对PI患者预后不良的预测效能。结果: PI组龈沟液leptin、HMGB1水平显著高于非PI组,SIRT1水平显著低于非PI组（P<0.001）;PI组PLI、SBI、PD均显著高于非PI组（P<0.001）。leptin、HMGB1与PLI、SBI、PD呈显著正相关（P<0.001）,SIRT1与PLI、SBI、PD呈显著负相关（P<0.001）。预后不良组（21例）发热率、Ⅳ期占比、白细胞计数（WBC）、C反应蛋白（CRP）、中性粒细胞（NG）及leptin、HMGB1 水平均显著高于预后良好组（40例）,SIRT1 水平显著低于预后良好组（P<0.05）。leptin、HMGB1、SIRT1 联合预测预后不良的曲线下面积（AUC）为 0.946（95%CI：0.892~0.985）,显著高于单一指标（P<0.05）。结论: 种植义齿修复并发PI患者龈沟液leptin、HMGB1高表达,SIRT1低表达,三者与PI发生及病情严重程度密切相关;联合检测对PI患者预后不良具有较高预测价值。

关键词: 龈沟液, 瘦素, 高迁移率族蛋白 B1, 沉默信息调节因子 1, 种植体周炎, 种植义齿修复, 预后预测

Abstract: PURPOSE: To explore the correlation between gingival crevicular fluid leptin, high mobility group protein B1 (HMGB1), silent information regulator 1 (SIRT1) and peri-implantitis (PI) in patients with dental implant restoration, and their predictive value for poor prognosis. METHODS: A total of 295 patients who received dental implant restoration at the Affiliated Hospital of Jiangnan University from July 2020 to July 2024 were enrolled, including 61 patients with PI (PI group) and 234 patients with healthy implants (non-PI group). ELISA was used to detect the levels of leptin, HMGB1 and SIRT1 in gingival crevicular fluid. Pearson method was used to analyze the correlation between the three indicators and plaque index (PLI), sulcular bleeding index (SBI), probing depth (PD). ROC curve was used to evaluate the predictive efficacy of the three indicators for poor prognosis in PI patients. RESULTS: GCF levels of leptin and HMGB1 were significantly higher, while SIRT1 levels were significantly lower in the PI group compared to the non-PI group (P<0.001). PLI, SBI, and PD were also significantly elevated in the PI group (P<0.001). Leptin and HMGB1 showed significant positive correlations with PLI, SBI and PD (P<0.001), whereas SIRT1 exhibited significant negative correlations with these clinical indices (P<0.001). Among PI patients, those with poor prognosis (n=21) had significantly higher rates of fever, greater proportion of stage IV disease, elevated white blood cell count (WBC), C-reactive protein (CRP), neutrophil count (NG), and higher GCF levels of leptin and HMGB1, along with significantly lower SIRT1 levels, compared to those with favorable prognosis (n=40) (P<0.05). The area under the curve (AUC) of leptin, HMGB1 and SIRT1 combined to predict poor prognosis was 0.946 (95%CI: 0.892-0.985), which was significantly higher than that of single indicators(P<0.05). CONCLUSIONS: Patients with dental implant restoration complicated with PI have high expression of leptin and HMGB1 and low expression of SIRT1 in gingival crevicular fluid, which are closely related to the occurrence and severity of PI. Combined detection of the three indicators has high predictive value for poor prognosis of PI patients.

Key words: Gingival crevicular fluid, Leptin, HMGB1, SIRT1, Peri-implantitis, Dental implant restoration, Prognostic prediction

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