NF1相关神经纤维瘤炎症微环境的研究进展

doi:10.19438/j.cjoms.2021.04.018

中国口腔颌面外科杂志 ›› 2021, Vol. 19 ›› Issue (4): 376-379.doi: 10.19438/j.cjoms.2021.04.018

NF1相关神经纤维瘤炎症微环境的研究进展

游元和, 王延安

上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海交通大学口腔医学院, 国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海 200011

收稿日期:2020-11-18 修回日期:2021-02-01 出版日期:2021-07-20 发布日期:2021-08-05
通讯作者: 王延安,E-mail: wangyan_an@163.com
作者简介:游元和（1995-）,男,硕士,E-mail: youyh0527@163.com

Research progress of inflammatory microenvironment in NF1 related neurofibroma

YOU Yuan-he, WANG Yan-an

Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China

Received:2020-11-18 Revised:2021-02-01 Online:2021-07-20 Published:2021-08-05

摘要/Abstract

摘要： 神经纤维瘤是I型神经纤维瘤病的特征性症状之一,终生进展,治疗难度大,而其发病机制仍不明确。瘤内的施万细胞呈NF1双等位基因失活状态,可激活RAS-GTP信号转导,继而释放大量细胞因子,为免疫细胞的募集提供了富含细胞因子的微环境。相较于免疫炎症细胞在正常外周神经中的低占比率,在NF1相关神经纤维瘤中,30%的细胞是单核细胞/巨噬细胞,亦可见肥大细胞、T细胞和树突状细胞。越来越多的研究表明,炎症与肿瘤的形成密切相关。本文从肿瘤炎症微环境方面综述NF1相关神经纤维瘤微环境内相关炎症细胞的研究进展。

关键词: I型神经纤维瘤病, 神经纤维瘤, 肥大细胞, 巨噬细胞, 肿瘤炎症微环境

Abstract: Neurofibroma is one of the characteristic lesions of neurofibromatosis type 1. However, the pathogenesis of neurofibromas is still not completely known. The highly active RAS-GTP signal transduction of Schwann cells with biallelic inactivation can produce a large number of cytokines, which provides a cytokine-rich microenvironment for immune cell recruitment. In normal peripheral nerves, the proportion of immune inflammatory cells is not high. In NF1-related neurofibromas, 30% of the cells are monocytes/macrophages. Mast cells, T cells and dendritic cells (DC) also present. Increased evidences indicate that there is a correlation between inflammation and tumorigenesis. This review summarized the research progress of inflammatory cells in the microenvironment of NF1-related neurofibroma.

Key words: Neurofibromatosis type 1, Neurofibroma, Mast cell, Macrophage, Tumor inflammatory microenvironment

中图分类号:

R739.8

游元和, 王延安. NF1相关神经纤维瘤炎症微环境的研究进展[J]. 中国口腔颌面外科杂志, 2021, 19(4): 376-379.

YOU Yuan-he, WANG Yan-an. Research progress of inflammatory microenvironment in NF1 related neurofibroma[J]. China J Oral Maxillofac Surg, 2021, 19(4): 376-379.

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NF1相关神经纤维瘤炎症微环境的研究进展

Research progress of inflammatory microenvironment in NF1 related neurofibroma

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