IFNAR1在口腔鳞状细胞癌中的表达及意义

doi:10.19438/j.cjoms.2017.03.010

中国口腔颌面外科杂志 ›› 2017, Vol. 15 ›› Issue (3): 240-244.doi: 10.19438/j.cjoms.2017.03.010

IFNAR1在口腔鳞状细胞癌中的表达及意义

朱黎琳¹,²，杨文艺¹，马海龙¹*，胡镜宙¹*

1.上海交通大学医学院附属第九人民医院·口腔医学院口腔颌面-头颈肿瘤科，上海市口腔医学重点实验室, 上海 200011；
2.复旦大学附属中山医院青浦分院口腔科，上海 201700

收稿日期:2016-10-17 修回日期:2017-01-26 出版日期:2017-05-20 发布日期:2017-06-09
通讯作者: 国家自然科学基金（31140007，81472516）；上海市自然科学基金（14ZR1424200）
作者简介:朱黎琳（1985-），女，在读硕士研究生，主治医师，E-mail:zll19850507@163.com
基金资助:
胡镜宙，E-mail: huyayi@163.com；马海龙，E-mail:mahl21@sjtu.edu.cn。*共同

Expression and significance of IFNAR1 in oral squamous cell carcinoma

ZHU Li-lin¹,², YANG Wen-yi¹, MA Hai-long¹, HU Jing-zhou¹.

1.Department of Oromaxillofacial Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology. Shanghai 200011；
2.Department of Stomatology, Zhongshan Hospital Qingpu Branch, Fudan University. Shanghai 201700, China

Received:2016-10-17 Revised:2017-01-26 Online:2017-05-20 Published:2017-06-09

摘要/Abstract

摘要： 目的：观察Ⅰ型干扰素受体1（type I interferon receptor 1，IFNAR1）在口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）及正常口腔黏膜中的表达，探讨其与患者临床特征及预后的关系。方法：应用免疫组织化学方法检测IFNAR1在108例OSCC及16例正常黏膜组织中的表达水平，分析IFNAR1的表达水平与OSCC临床病理特征的关系。采用SPSS17.0软件包对数据进行统计学分析。结果：IFNAR1在OSCC的表达水平比正常黏膜组织高。IFNAR1的表达水平与T分期、颈淋巴结转移、TNM分期及病理分化程度显著相关（P<0.05）；与患者的性别、年龄、发生部位、吸烟和饮酒无相关性（P>0.05）。IFNAR1表达对OSCC患者生存预后的HR=1.879 （95%CI=0.967-3.651，P=0.063）。Log-rank检验显示，IFNAR1表达高低与OSCC患者预后相关（P=0.057）。结论：IFNAR1在OSCC患者中高表达，其表达上调对OSCC是一个潜在的危险因子，与OSCC患者的预后有相关趋势。

关键词: IFNAR1, 免疫组织化学, 口腔鳞状细胞癌

Abstract: PURPOSE: To investigate the expression of type I interferon receptor 1(IFNAR1) in oral squamous cell carcinoma (OSCC) and normal mucosa, and to explore its relationship with clinical pathological characteristics and prognosis. METHODS: The expression of IFNAR1 in 108 cases with OSCC and 16 cases with normal oral mucosa was detected by immunohistochemistry. The relationship between the expression of IFNAR1 in OSCC tissues and clinical pathological characteristics were analyzed. The data were analyzed with SPSS17.0 software package. RESULTS: The expression of IFNAR1 in OSCC was significantly higher than that in normal oral mucosa. The expression of IFNAR1 was closely correlated with T stage, cervical lymph node metastasis, TNM stage and pathological differentiation (P<0.05); while gender, age, location, smoking and drinking had no correlation with IFNAR1 (P>0.05). IFNAR1 expression was an important factor to predict prognosis of OSCC patients with HR=1.879(95% CI=0.967-3.651, P=0.063). Patients with higher expression of IFNAR1 had poorer prognosis shown by Log-rank test (P=0.057). CONCLUSIONS: The expression of IFNAR1 in OSCC was significantly higher than that in normal oral mucosa, and it is a potential risk factor for OSCC. It has a tendency to be related to the prognosis of OSCC patients. IFNAR1 expression in tumor tissues can be a surrogate to select patients who can benefit from interferon alpha treatment in OSCC.

Key words: IFNAR1, Immunohistochemistry, Oral squamous cell carcinoma

中图分类号:

R739.8

朱黎琳,杨文艺，马海龙*，胡镜宙*. IFNAR1在口腔鳞状细胞癌中的表达及意义[J]. 中国口腔颌面外科杂志, 2017, 15(3): 240-244.

ZHU Li-lin, YANG Wen-yi, MA Hai-long, HU Jing-zhou.. Expression and significance of IFNAR1 in oral squamous cell carcinoma[J]. China J Oral Maxillofac Surg, 2017, 15(3): 240-244.

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IFNAR1在口腔鳞状细胞癌中的表达及意义

Expression and significance of IFNAR1 in oral squamous cell carcinoma

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