COX-2与骨代谢关系的研究进展

摘要/Abstract

摘要： 环氧化酶2 (cyclooxygenase-2, COX-2)是花生四烯酸（arachidonic acid, AA）合成前列腺素E2（prostaglandin E2, PGE2)的限速酶，通过对PGE2的调控，COX-2能够对骨代谢中骨形成和骨吸收产生多种不同的作用。同时，COX-2也能通过参与多条信号转导途径，影响骨的形成，包括G蛋白α亚基(guanine nucleotide-binding proteins alpha s, Gαs)信号通路、促丝裂原激活蛋白激酶（mitogen-activated protein kinases，MAPKs）通路以及核因子受体激活物配基（receptor activator of nuclear factor κB ligand，RANKL）信号通路。COX-2的产生由多种因素诱导，并可被其抑制剂如非甾体类抗炎药（non-steroidal anti-inflammatory drugs，NSAID)抑制。这些因素能调控COX-2的产量并最终作用于骨组织。本文就COX-2与骨形成的关系及其在相关临床应用上的展望进行介绍。

关键词: 环氧化酶2, 前列腺素, 骨形成, 成骨细胞, 破骨细胞

Abstract: Cyclooxygenase-2 (COX-2) is the rate-limiting enzyme of arachidonic acid (AA) synthesizing prostaglandin E2 (PGE2). It has various effects on bone metabolism that stimulate both bone resorption and formation through regulation of PGE2. Meanwhile, COX-2 can work by the participation of multiple signal transduction pathways in bone formation, including Gαs signaling pathway, mitogen-activated protein kinases (MAPKs) pathway and receptor activator of nuclear factor κB ligand (RANKL) signaling pathway. COX-2 was induced by many factors, and can be inhibited by the inhibitors such as non-steroidal anti-inflammatory drugs (NSAIDs). These factors can regulate the production of COX-2 and consequently have impact on bone tissue. The main PURPOSE of the article was to introduce the relationship between COX-2 and bone formation and its potential clinical applications.

Key words: Cyclooxygenase-2, Prostaglandin, Bone formation, Osteoblast, Osteoclast

中图分类号:

Q257

马吴迪，夏伦果，周宇宁，徐袁瑾. COX-2与骨代谢关系的研究进展[J]. 中国口腔颌面外科杂志, 2016, 14(1): 83-88.

MA Wu-di, XIA Lun-guo, ZHOU Yu-ning, XU Yuan-jin. Research progress of the relationship between COX-2 and bone formation[J]. China J Oral Maxillofac Surg, 2016, 14(1): 83-88.

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