中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2014, Vol. 12 ›› Issue (4): 328-332.

• 临床研究 • 上一篇    下一篇

MIC-1在婴幼儿血管瘤中的表达及其与VEGF、p53表达的相关性

孙桦梁1, 徐大鹏1, 薛雷1, 孙宁宁1, 钟鸣2, 王绪凯1   

  1. 1.中国医科大学口腔医学院 口腔颌面外科,辽宁省口腔医学研究所 口腔颌面外科研究室,辽宁 沈阳 110002;
    2.中国医科大学口腔医学院 病理科,中心实验室,辽宁 沈阳 110002
  • 收稿日期:2013-11-25 出版日期:2014-07-10 发布日期:2014-08-20
  • 通讯作者: 王绪凯,Tel:024-22892451,E-mail：wangxukai757892@sina.com
  • 作者简介:孙桦梁（1987-）,男,硕士研究生,E-mail:sunhualiang0609@sina.com
  • 基金资助:
    辽宁省教育厅科研基金(2009A747)

Expression and correlation of MIC-1, VEGF and p53 in infantile hemangioma

SUN Hua-liang1, XU Da-peng1, XUE Lei1, SUN Ning-ning1, ZHONG Ming2, WANG Xu-kai   

  1. 1.Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, Liaoning Institute of Dental Research. Shenyang 110002;
    2.Department of Pathology, Central Laboratory, School of Stomatology, China Medical University. Shenyang 110002, Liaoning Province, China
  • Received:2013-11-25 Online:2014-07-10 Published:2014-08-20
  • Supported by:
    Supported by Research Fund of Department of Education of Liaoning Province (2009A747)

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摘要： 目的 研究巨噬细胞抑制因子1（macrophage inhibitory cytokine-1,MIC-1）与血管内皮细胞生长因子（vascular endothelial growth factor,VEGF）以及p53在婴幼儿血管瘤中的表达及其关系,探讨MIC-1在血管瘤发病过程中的作用。方法：采用免疫组织化学SABC法检测血管瘤组织标本中MIC-1和VEGF、p53的表达情况,分析MIC-1与VEGF、p53在不同时期婴幼儿血管瘤中表达的相关性。采用SPSS17.0软件包进行χ2检验、Spearman等级相关分析。结果：MIC-1在增殖期和消退期血管瘤中的阳性表达率分别为85.19%和34.78%,2组之间差异显著(P<0.01);VEGF在增殖期和消退期血管瘤中的阳性表达率分别为96.30%和43.48%,2组之间差异显著(P<0.01);p53在增殖期和消退期血管瘤中的阳性表达率分别为81.48%和30.43%,2组之间差异显著(P<0.01);MIC-1在血管畸形和正常皮肤组织中不表达或低表达。MIC-1与VEGF的表达呈正相关 (r=0.613,P<0.01),与p53的表达也呈正相关(r=0.753,P<0.01)。结论：MIC-1可能与血管瘤的发病及发展有密切关系。

关键词: 血管瘤, 巨噬细胞抑制因子1, 血管内皮细胞生长因子, p53

Abstract: PURPOSE: To investigate the expression and correlation of MIC-1, VEGF and p53 in infantile hemangioma and to clarify the role of MIC-1 in hemangioma evolution. METHODS: Fifty hemangiomas (27 in proliferative phase and 23 in involuting phase) were examined immunohistochemically by SABC method. Statistical analysis was carried out using SPSS 17.0 software package. RESULTS: MIC-1 was expressed in 85.19% of proliferative hemangiomas, whereas 34.78% in involuting hemangiomas, there was significant difference between proliferation and involuting hemangiomas (P<0.01).MIC-1 was weakly expressed in normal skin and vascular malformations. VEGF was expressed in 96.30% of proliferative hemangiomas, whereas 43.48% in involuting hemangiomas; there was significant difference between proliferation and involuting hemangiomas (P<0.01). p53 was expressed in 81.48% of proliferative hemangiomas, whereas 30.43% in involuting hemangiomas, there was significant difference between proliferation and involuting hemangiomas (P<0.01). There was a significant positive correlation between the expression of MIC-1 and VEGF(r=0.613,P<0.01), and also between MIC-1 and p53 (r=0.753,P<0.01). CONCLUSIONS: MIC-1 plays an important role in the development and progress of infantile hemangiomas.

Key words: Infantile hemangioma, MIC-1, VEGF, p53

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