中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2026, Vol. 24 ›› Issue (3): 317-319.doi: 10.19438/j.cjoms.2026.03.017

• 病例报告 • 上一篇    下一篇

牙龈外周性黏液瘤1例报告

卞轶夫1,2*, 申佳玉1,2*, 段新亮1,2, 程雪2, 韩冰1,2   

  1. 1.吉林大学口腔医院 口腔颌面外科,吉林 长春 130021;
    2.牙发育及颌骨重塑与再生实验室,吉林 长春 130021
  • 收稿日期:2025-12-02 修回日期:2026-01-12 出版日期:2026-05-20 发布日期:2026-06-04
  • 通讯作者: 韩冰,E-mail: hbing@jlu.edu.cn
  • 作者简介:卞轶夫（1999—）,男,在读硕士研究生,E-mail: bianyf23@mails.jlu.edu.cn;申佳玉（1999—）,女,在读博士研究生,E-mail: shenjy22@mails.jlu.edu.cn。*并列第一作者
  • 基金资助:
    吉林省科技发展计划项目（20230204079YY）

Peripheral myxoma of the gingiva: a case report

Bian Yifu1,2, Shen Jiayu1,2, Duan Xinliang1,2, Cheng Xue2, Han Bing1,2   

  1. 1. Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Jilin University. Changchun 130021;
    2. Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Jilin University. Changchun 130021, Jilin Province, China
  • Received:2025-12-02 Revised:2026-01-12 Online:2026-05-20 Published:2026-06-04

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摘要： 发生于牙龈等软组织的外周性黏液瘤较少见。本文报告1例右侧上颌牙龈外周性黏液瘤病例。患者为74岁女性,14-16牙颊侧牙龈出现无痛性蒂状肿物1年余,影像检查未见颌骨破坏。全麻下局部广泛切除并行骨面刮除及超声骨刀打磨。HE显示丰富黏液样基质内散在梭形/星形细胞,异形性轻,核分裂罕见,局灶少量炎细胞,未见明确牙源性上皮成分。免疫组织化学染色显示Vimentin阳性,SMA局灶阳性,CK阴性,Ki-67约20%。需与外周性牙源性黏液瘤（peripheral odontogenic myxoma,POM）及牙龈瘤伴黏液变性鉴别。本病例提示牙龈黏液样肿物来源判断需谨慎,对无骨侵犯者宜行足量软组织切除联合骨面刮除并长期随访,以降低复发风险。

关键词: 黏液瘤, 外周性黏液瘤, 牙龈肿物

Abstract: Peripheral myxoma arising in soft tissues such as the gingiva is a rare entity. This article reported a case of peripheral myxoma of the right maxillary gingiva in a 74-year-old female patient who presented with a painless pedunculated mass on the buccal gingiva adjacent to the right maxillary teeth 14 to 16 for more than one year. Imaging examinations revealed no jaw bone destruction. Wide local excision under general anesthesia was performed, along with curettage of the bony surface and grinding with an ultrasonic bone knife. Hematoxylin-eosin (HE) staining showed scattered spindle/stellate cells in an abundant myxoid stroma with mild atypia, rare mitoses, and a focal mild inflammatory cell infiltrate; no definite odontogenic epithelial components were identified. Immunohistochemical staining demonstrated positive Vimentin expression, focal positive SMA expression, negative CK expression, and a Ki-67 proliferation index of approximately 20%. Peripheral myxoma needed to be differentiated from peripheral odontogenic myxoma (POM) and epulis with myxoid degeneration. This case suggested that the origin of gingival myxoid masses should be determined with caution. For lesions without bone invasion, adequate soft tissue excision combined with bony surface curettage and long-term follow-up are recommended to reduce the risk of recurrence.

Key words: Myxoma, Peripheral myxoma, Gingival mass

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