高频超声检查在腮腺疾病诊疗中的应用研究进展

doi:10.19438/j.cjoms.2026.02.014

摘要/Abstract

摘要： 腮腺疾病类型丰富,涵盖肿瘤性病变、炎症性疾病及自身免疫性疾病等。由于腮腺解剖结构复杂,且与面神经等重要结构紧密关联,术前精准诊断对手术方案制定及患者预后改善具有直接影响。高频超声（high-frequency ultrasound, HFUS）作为腮腺疾病首选影像学检查手段,凭借实时成像、无创操作、高分辨率等突出优势,在疾病诊断、治疗决策及术后随访中发挥着关键作用。近年来,随着弹性成像、超声造影及介入超声等新技术的不断发展,HFUS在腮腺疾病诊疗中的应用价值得到显著提升。本文综述了HFUS的技术优势,详细阐述其在腮腺疾病诊断、良恶性肿瘤鉴别以及腮腺解剖评估（肿瘤与面神经位置关系判断）中的具体应用,同时深入探讨该技术的优缺点及未来发展方向,旨在为临床实践提供更全面的参考。

关键词: 腮腺疾病, 高频超声, 弹性成像, 超声造影, 影像诊断

Abstract: Parotid gland diseases are highly diverse, including neoplastic lesions, inflammatory diseases, autoimmune diseases, and etc. Owing to the complex anatomical structure of the parotid gland and its involvement with vital structures such as the facial nerve, accurate preoperative diagnosis directly influences the making of surgical plans and prediction of the prognosis of patients. High-frequency ultrasound(HFUS), as the preferred imaging examination method for parotid gland diseases, plays a crucial role in disease diagnosis, treatment decision-making, and follow-up due to its advantages of real-time imaging, non-invasiveness, and high resolution. In recent years, with the development of new technologies like elastography, contrast-enhanced ultrasound, and interventional ultrasound, the application value of HFUS in the diagnosis and treatment of parotid gland diseases has been significantly enhanced. This article reviewed the technical advantages of HFUS, elaborated on its applications in the diagnosis of parotid gland diseases, the differentiation of benign and malignant tumors, and the anatomical assessment of the parotid gland (determining the positional relationship between tumors and facial nerve), and discussed the technical strengths, weaknesses, and future development directions of this technology.

Key words: Parotid gland diseases, High-frequency ultrasound, Elastography, Contrast-enhanced ultrasound, Imaging diagnosis

中图分类号:

孙智超, 石文静, 陈岗. 高频超声检查在腮腺疾病诊疗中的应用研究进展[J]. 中国口腔颌面外科杂志, 2026, 24(2): 185-189.

Sun Zhichao, Shi Wenjing, Chen Gang. Research progress on the application of high-frequency ultrasound examination in the diagnosis and treatment of parotid gland diseases[J]. China J Oral Maxillofac Surg, 2026, 24(2): 185-189.

参考文献

[1] Dong Y, Lei GW, Wang SW, et al.Diagnostic value of CT perfusion imaging for parotid neoplasms[J]. Dentomaxillofac Radiol, 2014, 43(1): 20130237.
[2] MacFarlane D, Shah K, Wysong A, et al. The role of imaging in the management of patients with nonmelanoma skin cancer: diagnostic modalities and applications[J]. J Am Acad Dermatol, 2017, 76(4): 579-588.
[3] 李治群, 孙笑芬, 徐钐, 等. MRI多参数联合评分对腮腺肿瘤的定性诊断价值[J]. 放射学实践, 2023, 38(9): 1114-1120.
Li ZQ, Sun XF, Xu S, et al.The qualitative diagnostic value of MRI multiparameter combined scoring for the diagnosis of parotid gland tumors[J]. Radiologic Practice, 2023, 38(9): 1114-1120.
[4] Pavlin CJ, Foster FS.Ultrasound biomicroscopy. high-frequency ultrasound imaging of the eye at microscopic resolution[J]. Radiol Clin North Am, 1998, 36(6): 1047-1058.
[5] 徐辉雄, 郭乐杭. 高频超声在皮肤疾病诊断中的应用[J]. 肿瘤影像学, 2019, 28(5): 289-295.
Xu HX, Guo LH.Application of high-frequency ultrasound in dermatology diseases[J]. Journal of Tumor Imaging, 2019, 28(5): 289-295.
[6] Maehara A, Matsumura M, Ali ZA, et al.IVUS-guided versus OCT-guided coronary stent implantation: a critical appraisal[J]. JACC Cardiovasc Imaging, 2017, 10(12): 1487-1503.
[7] Albano D, Aringhieri G, Messina C, et al.High-frequency and ultra-high frequency ultrasound: musculoskeletal imaging up to 70 MHz[J]. Semin Musculoskelet Radiol, 2020, 24(2): 125-134.
[8] Jiang Z, Guo J, Hu L, et al.Comparative analysis of elastosonography and ¹⁸F-FDG PET/CT in differentiating benign and malignant salivary gland tumors: a systematic review and meta-analysis[J]. BMC Oral Health, 2025, 25(1): 464.
[9] Zhang YF, Li H, Wang XM, et al.Sonoelastography for differential diagnosis between malignant and benign parotid lesions: a meta-analysis[J]. Eur Radiol, 2019, 29(2): 725-735.
[10] 马倩, 毛翠莲, 李奥, 等. 声触诊组织成像定量技术联合高频超声诊断腮腺肿块良恶性的临床价值[J]. 实用临床医药杂志, 2023, 27(14): 9-12.
Ma Q, Mao CL, Li A, et al.Clinical value of virtual touch tissue imaging quantification technique combined with high-frequency ultrasound in diagnosis of benign and malignant parotid masses[J]. Journal of Practical Clinical Medicine, 2023, 27(14): 9-12
[11] 袁汝亮, 冯岚, 吴丽琴, 等. 流行性腮腺炎感染儿童腮腺及腹部的声像图研究[J]. 中华医院感染学杂志, 2017, 27(14): 3315-3318.
Yuan RL, Feng L, Wu LQ, et al.Sonopraphic images of parotid gland and abdomen of children with mumps[J]. Chinese Journal of Hospital Infection, 2017, 27(14): 3315-3318.
[12] 赵晓洁. 高频超声诊断流行性腮腺炎的临床研究[J]. 影像研究与医学应用, 2020, 4(6): 147-148.
Zhao XJ.Clinical study on the diagnosis of epidemic mumps by high-frequency ultrasound[J]. Journal of Imaging Research and Medical Applications, 2020, 4(6): 147-148.
[13] 向清玉, 王淑萍, 董艳娥, 等. 超声及实验室检查在流行性腮腺炎防治中的应用及分析[J]. 医疗卫生装备, 2016, 37(11): 69-71.
Xiang QY, Wang SP, Dong YE, et al.Application of ultrasound and clinical laboratory examinations to prevention and treatment of epidemic parotitis[J].Medical and Health Equipment, 2016, 37(11): 69-71.
[14] 陆一凡, 张蔚蒨, 俞创奇. 过敏相关阻塞性腮腺炎的临床分析及超声研究[J]. 上海交通大学学报(医学版), 2023, 43(5): 519-523.
Lu YF, Zhang WQ, Yu CQ, et al.Clinical analysis and ultrasound study of allergy-related obstructive parotitis[J]. Journal of Shanghai Jiao Tong University (Medical Edition), 2023, 43(5): 519-523.
[15] Sriskandan N, Hannah A, Howlett DC.A study to evaluate the accuracy of ultrasound in the diagnosis of parotid lumps and to review the sonographic features of parotid lesions-results in 220 patients[J]. Clin Radiol, 2010, 65(5): 366-372.
[16] Bialek EJ, Jakubowski W, Zajkowski P, et al.US of the major salivary glands: anatomy and spatial relationships, pathologic conditions, and pitfalls[J]. Radiographics, 2006, 26(3): 745-763.
[17] 刘继延, 赵文峰, 王淑梅, 等. 超声在腮腺肿瘤诊断中的价值[J]. 中国超声医学杂志, 2013, 29(4): 296-298.
Liu JY, Zhao WF, Wang SM, et al.Value of ultrasound in diagnosis of parotid gland tumors[J]. Chinese Journal of Ultrasound Medicine, 2013, 29(4): 296-298.
[18] Onkar PM, Ratnaparkhi C, Mitra K.High-frequency ultrasound in parotid gland disease[J]. Ultrasound Q, 2013, 29(4): 313-321.
[19] 胡南立, 黄声岳. 高频超声诊断在腮腺肿瘤诊断中的价值及误诊分析[J]. 现代实用医学, 2015, 27(1):116-118.
Hu NL, Huang SY.The value of high-frequency ultrasound diagnosis in the diagnosis of parotid tumors and analysis of misdiagnosis[J]. Modern Practical Medicine, 2015, 27(1): 116-118.
[20] 赵斐, 李鹏, 刘津灵. 高频超声对腮腺占位性病变的诊断价值[J]. 临床耳鼻咽喉头颈外科杂志, 2020, 34(7): 630-633.
Zhao F, Li P, Liu JL.Diagnostic value of high-resolution ultrasonography in parotid space occupying lesions[J]. Journal of Clinical Otorhinolaryngology Head and Neck Surgery, 2020, 34(7): 630-633.
[21] 陈志奎, 张秀娟, 黄静, 等. 高频超声诊断腮腺肿瘤[J]. 中国医学影像技术, 2011, 27(9): 1775-1778.
Chen ZK, Zhang XJ, Huang J, et al.High frequency ultrasound in diagnosis of parotid tumors[J]. Chinese Journal of Medical Imaging Technology, 2011, 27(9): 1775-1778.
[22] 丛颖, 杨芳, 侯兴华, 等. 高频彩超对腮腺肿瘤的诊断与鉴别诊断价值[J]. 中国中西医结合影像学杂志, 2015, 13(1):34-36.
Cong Y, Yang F, Hou XH, et al.Diagonosis and differential diagnosis value of high frequency color Doppler flow imaging for parotid tumors[J]. Chinese Imaging Journal of Integrated Traditional and Western Medicine, 2015, 13(1): 34-36.
[23] Klintworth N, Zenk J, Koch M, et al.Postoperative complications after extracapsular dissection of benign parotid lesions with particular reference to facial nerve function[J]. Laryngoscope, 2010, 120(3): 484-490.
[24] Ruohoalho J, Makitie AA, Aro K, et al.Complications after surgery for benign parotid gland neoplasms: a prospective cohort study[J]. Head Neck, 2017, 39(1): 170-176.
[25] Olsen KD, Quer M, de Bree R, et al. Deep lobe parotidectomy-why, when, and how?[J]. Eur Arch Otorhinolaryngol, 2017, 274(12): 4073-4078.
[26] Kurabayashi T, Ida M, Ohbayashi N, et al.Criteria for differentiating superficial from deep lobe tumours of the parotid gland by computed tomography[J]. Dentomaxillofac Radiol, 1993, 22(2): 81-85.
[27] Smith JR, King WW, Tang WY, et al.Differentiating tumours of the deep and superficial lobes of the parotid gland by computed tomographic sialography[J]. Clin Radiol, 1987, 38(4): 345-349.
[28] Sumi M, Van Cauteren M, Takagi Y, et al.Balanced turbo field-echo sequence for MRI of parotid gland diseases[J]. AJR Am J Roentgenol, 2007, 188(1): 228-232.
[29] Psychogios G, Rueger H, Jering M, et al.Ultrasound can help to indirectly predict contact of parotid tumors to the facial nerve, correct intraglandular localization, and appropriate surgical technique[J]. Head Neck, 2019, 41(9): 3211-3218.
[30] Kim JK, Lee DW, Geum S, et al.Ultrasonographic localization of parotid gland tumor relative to the facial nerve using Stensen's duct criterion[J]. J Oral Maxillofac Surg, 2023, 81(8): 1055-1061.
[31] Imaizumi A, Kuribayashi A, Okochi K, et al.Differentiation between superficial and deep lobe parotid tumors by magnetic resonance imaging: usefulness of the parotid duct criterion[J]. Acta Radiol, 2009, 50(7): 806-811.
[32] Lee SK, Rho BH, Won KS.Parotid incidentaloma identified by combined ¹⁸F-fluorodeoxyglucose whole-body positron emission tomography and computed tomography: findings at grayscale and power Doppler ultrasonography and ultrasound-guided fine-needle aspiration biopsy or core-needle biopsy[J]. Eur Radiol, 2009, 19(9): 2268-2274.
[33] Mantsopoulos K, Psychogios G, Agaimy A, et al.Inflamed benign tumors of the parotid gland: diagnostic pitfalls from a potentially misleading entity[J]. Head Neck, 2015, 37(1): 23-29.
[34] Dinnes J, Bamber J, Chuchu N, et al. High-frequency ultrasound for diagnosing skin cancer in adults[J]. Cochrane Database Syst Rev, 2018, 12(12): CD013188.
[35] Ma B, Wu G, Zhu H, et al.The prediction model of high-frequency ultrasound combined with artificial intelligence-assisted scoring system improved the diagnosis of sclerosing adenosis and early breast cancer[J]. Breast Cancer (Dove Med Press), 2025, 17: 145-155.