颈部淋巴外科治疗阿尔茨海默病临床研究现状

doi:10.19438/j.cjoms.2025.05.015

中国口腔颌面外科杂志 ›› 2025, Vol. 23 ›› Issue (5): 523-526.doi: 10.19438/j.cjoms.2025.05.015

颈部淋巴外科治疗阿尔茨海默病临床研究现状

陈由骏¹, 李霞², 王延安³, 张志愿³, 任振虎³

1.上海交通大学口腔医学院,上海 200125;
2.上海交通大学医学院附属精神卫生中心,上海 200030;
3.上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011

收稿日期:2025-04-07 修回日期:2025-06-27 发布日期:2025-10-10
通讯作者: 任振虎,E-mail: zhenhuren@126.com
作者简介:陈由骏（2002-）,男,本科,E-mail: jameschenyj@qq.com
基金资助:
国家口腔疾病临床医学研究中心（上海九院）“口腔医学临床研究攻关项目（非定向项目）”（NCRCO202318）

Current status of clinical research on cervical lymphatic surgery for Alzheimer's disease

Chen Youjun¹, Li Xia², Wang Yan'an³, Zhang Zhiyuan³, Ren Zhenhu³

1. College of Stomatology, Shanghai Jiao Tong University. Shanghai 200125;
2. Shanghai Mental Health Center. Shanghai 200030;
3. Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology. Shanghai 200011, China

Received:2025-04-07 Revised:2025-06-27 Published:2025-10-10

摘要/Abstract

摘要： 颈部淋巴外科作为一种新兴治疗策略,旨在通过改善脑淋巴引流功能缓解阿尔茨海默病（Alzheimer's disease, AD）的病理进程。现有研究认为,颈部淋巴系统与脑内废物的清除密切相关,其功能障碍可能导致AD相关蛋白沉积及神经退行性病变。目前,淋巴管-静脉吻合术等外科技术被尝试用于恢复淋巴引流,但相关临床研究仍处于初步探索阶段,证据主要基于小规模病例报告和短期观察结果。尽管初步数据显示部分患者症状改善,但缺乏大样本随机对照试验及长期疗效验证,其机制亦未完全明确。现有证据不足以支持该疗法的广泛临床应用,需进一步开展高质量研究,以明确其安全性和有效性。

关键词: 颈部淋巴外科, 阿尔茨海默病, 颈颅类淋巴分流疏通术

Abstract: Cervical lymphatic surgery, as an emerging therapeutic strategy, aims to alleviate the pathological progression of Alzheimer's disease (AD) by improving brain lymphatic drainage. Studies suggest that the cervical lymphatic system is closely associated with the clearance of brain waste products, and its dysfunction may lead to AD-related protein deposition and neurodegenerative pathologies. Currently, surgical techniques such as lymphovenous anastomosis have been attempted to restore lymphatic drainage. However, related clinical research remains in its preliminary investigation stages, with evidence primarily based on small-sample case reports and short-term observational outcomes. Although initial data indicate symptom improvement in some patients, there is a lack of large-scale randomized controlled trials and long-term efficacy validation, and the underlying mechanisms remain incompletely explained. Existing evidence is insufficient to support the widespread clinical application of this therapy, requiring further high-quality research to clarify its safety and efficacy.

Key words: Cervical lymphatic surgery, Alzheimer's disease, Cervical shunting to unclog cerebral lymphatic systems

中图分类号:

陈由骏, 李霞, 王延安, 张志愿, 任振虎. 颈部淋巴外科治疗阿尔茨海默病临床研究现状[J]. 中国口腔颌面外科杂志, 2025, 23(5): 523-526.

Chen Youjun, Li Xia, Wang Yan'an, Zhang Zhiyuan, Ren Zhenhu. Current status of clinical research on cervical lymphatic surgery for Alzheimer's disease[J]. China J Oral Maxillofac Surg, 2025, 23(5): 523-526.

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颈部淋巴外科治疗阿尔茨海默病临床研究现状

Current status of clinical research on cervical lymphatic surgery for Alzheimer's disease

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