放射性口腔黏膜炎防治药物研究进展

doi:10.19438/j.cjoms.2025.02.015

摘要/Abstract

摘要： 放射性口腔黏膜炎是头颈癌患者接受放射治疗最常见的并发症之一，会引发黏膜溃疡、剧烈疼痛、进食和吞咽困难等功能障碍，致使治疗中断，影响疗效。目前认为，放射性口腔黏膜炎是一个多靶点的复杂动态过程，针对这些靶点进行药物治疗，可以预防和控制黏膜炎的发生、发展。本文针对黏膜炎的不同靶点，包括DNA损伤、氧化应激通路、口腔微生物群、上皮增殖、镇痛管理，对放射性黏膜炎的防治药物研究进展进行综述，为未来研究和临床防治放射性口腔黏膜炎提供参考与理论依据。

关键词: 放射治疗, 头颈癌, 放射性口腔黏膜炎, 靶点

Abstract: Radiation oral mucositis is one of the most common complications of radiotherapy in patients with head and neck cancer. It can lead to mucosal ulceration, severe pain, eating and swallowing difficulties and other functional disorders, resulting in treatment interruption and poor curative effect. Radiation oral mucositis is currently believed to be a complex and dynamic process with multiple targets, and drug therapy targeting these targets can prevent and control the occurrence and development of mucositis. This review discussed the research progress of drugs for prevention and treatment of radiation mucositis, aiming at different targets of mucositis, including DNA damage, oxidative stress pathway, oral microbiota, epithelial proliferation, and analgesic management, which will provide references for the future research and clinical prevention and treatment of radiation oral mucositis.

Key words: Radiation therapy, Head and neck cancer, Radiotherapy-induced oral mucositis, Target

中图分类号:

R781.5

王佳敏, 安韡, 陈文革. 放射性口腔黏膜炎防治药物研究进展[J]. 中国口腔颌面外科杂志, 2025, 23(2): 196-201.

WANG Jia-min, AN Wei, CHEN Wen-ge. Research progress on drugs for the prevention and treatment of radiotherapy-induced oral mucositis[J]. China J Oral Maxillofac Surg, 2025, 23(2): 196-201.

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