中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2024, Vol. 22 ›› Issue (4): 360-364.doi: 10.19438/j.cjoms.2024.04.007

• 论著 • 上一篇    下一篇

头颈癌治疗诱发的淋巴水肿：临床因素和预后分析

郭毅波1, 李晨尧2, 樊奇3, 季彤4, 任振虎1   

  1. 1.上海交通大学医学院附属第九人民医院 口腔颌面-头颈肿瘤科,2.口腔颌面外科, 上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011;
    3.上海交通大学医学院附属第九人民医院 影像科,上海 200011;
    4.复旦大学附属中山医院 口腔颌面外科,上海 200030
  • 收稿日期:2023-12-22 修回日期:2024-02-10 出版日期:2024-07-20 发布日期:2024-08-07
  • 通讯作者: 任振虎,E-mail: ren.zhenhu@outlook.com
  • 作者简介:郭毅波（1998-）,男,在读博士研究生,E-mail: guoyibo98@163.com
  • 基金资助:
    国家口腔疾病临床医学研究中心项目（NCRCO202318）

Head and neck cancer therapy-induced lymphedema: clinical factors and prognostic analysis

GUO Yi-bo1, LI Chen-yao2, FAN Qi3, JI Tong4, REN Zhen-hu1   

  1. 1. Department of Oromaxillofacial Head and Neck Oncology, 2. Department of Oral and Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Shanghai Research Institute of Stomatology. Shanghai 200011;
    3. Department of Radiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011;
    4. Department of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University. Shanghai 200030, China
  • Received:2023-12-22 Revised:2024-02-10 Online:2024-07-20 Published:2024-08-07

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摘要： 目的: 探讨头颈部恶性肿瘤患者淋巴水肿的严重程度与其相关临床数据之间的关系。方法: 对接受多模式治疗的79例头颈癌患者进行回顾性研究。基于术后6个月以上的磁共振成像结果进行淋巴水肿诊断和分级,通过查阅电子病历和电话随访获取相关信息。采用SPSS 26.0软件包对数据进行统计学分析。结果: 随着TNM分期、颈淋巴清扫范围的增加,患者淋巴水肿重度率增加。术前接受药物诱导化疗的患者与未接受化疗的患者相比,淋巴水肿重度率更高。不同严重水肿程度患者无瘤生存期无统计学差异。结论: 头颈部淋巴水肿的发生与肿瘤分期、淋巴清扫的程度以及综合治疗方式有一定相关性,仍需进一步关注和研究。

关键词: 淋巴水肿, 头颈癌, 综合治疗, 无瘤生存期

Abstract: PURPOSE: To analyze the correlation between the severity of lymphedema in patients with head and neck malignancies and relevant clinical data related to the tumors. METHODS: In this paper, a retrospective study was conducted on 79 patients with head and neck cancer who received multimodality treatment. The diagnosis and grading were conducted by MRI results of patients more than 6 months after surgery, and the electronic records and telephone follow-up data were utilized. SPSS 26.0 software package was used for data analysis. RESULTS: As TNM stage increased and the extent of cervical lymph node dissection expanded, the incidence rate of severe lymphedema in patients also rose. Compared to patients who did not receive chemotherapy before surgery, those who underwent preoperative drug-induced chemotherapy had a higher prevalence of severe lymphedema. However, there was no significant difference in the disease-free survival period among patients with varying degrees of severity of lymphedema. CONCLUSIONS: Head and neck lymphedema correlates with tumor stage, extent of lymphatic clearance, and comprehensive treatment modalities. However, further research and attention are still needed.

Key words: Lymphoedema, Head and neck cancer, Multimodality treatment, Disease-free survival

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