Dnmt3B在骨关节炎中的表观遗传调控机制研究文献的可视化分析

doi:10.19438/j.cjoms.2026.05.011

中国口腔颌面外科杂志 ›› 2026, Vol. 24 ›› Issue (5): 507-516.doi: 10.19438/j.cjoms.2026.05.011

Dnmt3B在骨关节炎中的表观遗传调控机制研究文献的可视化分析

骆家承¹, 陈嘉俣², 周筱璇², 张睿嫣², 戚余钺², 徐誉甄², 黄铄婷², 崔辰绮², 孙紫伊², 刘小涵³, 熊颖盈³, 王烨欣^3,*, 张善勇^3,*

1.上海交通大学口腔医学院,上海 200011;
2.上海交通大学医学院,上海 200030;
3.上海交通大学医学院附属第九人民医院口腔外科,上海 200011

收稿日期:2026-02-12 修回日期:2026-03-23 出版日期:2026-09-20 发布日期:2026-10-10
通讯作者: 王烨欣,E-mail：wangyexin1993@163.com;张善勇,E-mail：zhangshanyong@126.com。^*共同通信作者
作者简介:骆家承（2005—）,男,本科生,E-mail：johnsonluo_0330@126.com
基金资助:
上海市扬帆计划（23YF1421900）; 2023激励计划2（JXJL-2025-3）; 大学生创新训练计划（20260547）

Visualization analysis of literature on epigenetic regulatory mechanisms of Dnmt3B in osteoarthritis

Luo Jiacheng¹, Chen Jiayu², Zhou Xiaoxuan², Zhang Ruiyan², Qi Yuyue², Xu Yuzhen², Huang Shuoting², Cui Chenqi², Sun Ziyi², Liu Xiaohan³, Xiong Yingying³, Wang Yexin³, Zhang Shanyong³

1. College of Stomatology, Shanghai Jiao Tong University. Shanghai 200011;
2. Shanghai Jiao Tong University School of Medicine. Shanghai 200030;
3. Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China

Received:2026-02-12 Revised:2026-03-23 Online:2026-09-20 Published:2026-10-10

摘要/Abstract

摘要： 目的：分析DNA甲基转移酶3B（DNA methyltransferase 3B,Dnmt3B）在骨关节炎（osteoarthritis,OA）中的表观遗传调控机制研究的文献,了解该领域的研究脉络、热点方向与不足,为未来研究提供参考。方法：检索2010—2025年PubMed、Web of Science、Scopus、CNKI数据库相关原创文献,采用CiteSpace 6.3.R1进行关键词共现、聚类、突现及文献计量可视化分析。结果：最终纳入21篇有效文献。领域研究以DNA甲基化、软骨细胞、炎症为核心主题,研究重心从基础机制描述转向 Dnmt3B 特异通路解析;Dnmt3B通过调控 miR-34a、ABAT、Wnt/β-catenin 等通路参与软骨稳态、炎症反应与代谢重编程,天然化合物、动物模型与代谢表观遗传交叉为前沿方向,但现有研究多局限于单一通路、以基础实验为主,临床转化证据不足。结论：Dnmt3B是OA表观遗传调控的关键分子,其异常表达驱动软骨退变、骨重塑与滑膜炎症进程。未来需开展多组学整合、大样本临床队列与精准干预研究,建立基于Dnmt3B基因多态性及甲基化特征的诊断标志物体系。

关键词: 骨关节炎, DNA甲基转移酶3B, 表观遗传学, 可视化分析

Abstract: PURPOSE: To analyze the literature on epigenetic regulatory mechanisms of DNA methyltransferase 3B (Dnmt3B) in osteoarthritis (OA), delineate the research landscape, key trends, and limitations in this field, and provide insights for future studies. METHODS: Original publications published between 2010 and 2025 were retrieved from PubMed, Web of Science, Scopus, and CNKI databases. CiteSpace 6.3.R1 was employed for keyword co-occurrence analysis, clustering, prominence analysis, and bibliometric visualization. RESULTS: A total of 21 valid articles were identified. Research focuses primarily revolve around DNA methylation, chondrocytes, and inflammation, with an increasing emphasis shifting from fundamental mechanism elucidation to the analysis of Dnmt3B-specific signaling pathways. Dnmt3B is involved in maintaining cartilage homeostasis, inflammatory responses, and metabolic reprogramming through regulation of pathways such as miR-34a, ABAT, and Wnt/β-catenin. Interdisciplinary approaches incorporating natural compounds, animal models, and metabolic epigenetics represent emerging research directions; however, existing studies predominantly concentrate on single pathways and basic experiments, lacking sufficient clinical translational evidence. CONCLUSIONS: Dnmt3B serves as a pivotal molecular player in OA epigenetic regulation, with its aberrant expression driving cartilage degeneration, bone remodeling, and synovial inflammation. Future investigations should integrate multi-omics data, conduct large-scale clinical cohort studies, and develop precision intervention strategies, ultimately establishing diagnostic biomarker systems based on Dnmt3B genetic polymorphisms and methylation profiles.

Key words: Osteoarthritis, DNA methyltransferase 3B, Epigenetics, Visualization analysis

中图分类号:

骆家承, 陈嘉俣, 周筱璇, 张睿嫣, 戚余钺, 徐誉甄, 黄铄婷, 崔辰绮, 孙紫伊, 刘小涵, 熊颖盈, 王烨欣, 张善勇. Dnmt3B在骨关节炎中的表观遗传调控机制研究文献的可视化分析[J]. 中国口腔颌面外科杂志, 2026, 24(5): 507-516.

Luo Jiacheng, Chen Jiayu, Zhou Xiaoxuan, Zhang Ruiyan, Qi Yuyue, Xu Yuzhen, Huang Shuoting, Cui Chenqi, Sun Ziyi, Liu Xiaohan, Xiong Yingying, Wang Yexin, Zhang Shanyong. Visualization analysis of literature on epigenetic regulatory mechanisms of Dnmt3B in osteoarthritis[J]. China J Oral Maxillofac Surg, 2026, 24(5): 507-516.

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Dnmt3B在骨关节炎中的表观遗传调控机制研究文献的可视化分析

Visualization analysis of literature on epigenetic regulatory mechanisms of Dnmt3B in osteoarthritis

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