基于影像组学鉴定头颈部鳞状细胞癌患者HPV状态：诊断性meta分析

doi:10.19438/j.cjoms.2023.01.012

中国口腔颌面外科杂志 ›› 2023, Vol. 21 ›› Issue (1): 69-74.doi: 10.19438/j.cjoms.2023.01.012

基于影像组学鉴定头颈部鳞状细胞癌患者HPV状态：诊断性meta分析

李雪儿^1,2, 王正业³, 买买提吐逊·吐尔地^1,2

1.新疆医科大学第一附属医院（附属口腔医院）口腔颌面创伤正颌外科,新疆乌鲁木齐 830054;
2.新疆维吾尔自治区口腔医学研究所,新疆乌鲁木齐 830054;
3.新疆医科大学公共卫生学院,新疆乌鲁木齐 830054

收稿日期:2022-07-17 修回日期:2022-10-01 出版日期:2023-01-20 发布日期:2023-06-12
通讯作者: 买买提吐逊·吐尔地,E-mail: maimaitituxun@aliyun.com
作者简介:李雪儿（1997-）,女,在读硕士研究生,E-mail: 975411807@qq.com

Identification of HPV status in head and neck squamous cell carcinoma patients based on radiomics: diagnostic meta-analysis

LI Xue-er^1,2, WANG Zheng-ye³, TUERDI Maimaitituxun^1,2

1. Orthognathic and Trauma Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital (Stomatolgical Hospital) of Xinjiang Medical University. Urumqi 830011;
2. Stomatolgical Research Institute of Xinjiang Uygur Autonomous Region. Urumqi 830054;
3. College of Public Health, Xinjiang Medical University. Urumqi 830054, Xinjiang Uygur Autonomous Region, China

Received:2022-07-17 Revised:2022-10-01 Online:2023-01-20 Published:2023-06-12

摘要/Abstract

摘要： 目的： 采用诊断性meta方法,评价影像组学特征,构建模型,鉴定头颈部鳞状细胞癌患者人乳头瘤病毒（HPV）状态的价值。方法： 检索PubMed、Embase、Web of Science、中国知网、维普数据库中有关影像组学鉴定HPV状态的相关文献。检索时间为建库至2022年5月28日。采用Revman5.4等统计软件,评估预测模型的诊断效能。结果： 共纳入9篇文献,包括3 312例患者。合并结果显示,基于影像组学方法诊断患者HPV状态的敏感度为0.82[95%CI(0.74,0.87)],特异度为0.66[95%CI(0.54,0.75)], 阳性似然比为2.4[95%CI(1.8,3.1)],阴性似然比为0.28[95%CI(0.21,0.36)],诊断比值比为9[95%CI(6,12)],综合受试者工作特征曲线下面积(AUC)为0.82[95%CI(0.78,0.85)]。通过影像组学方法鉴定HPV状态先验概率为25%,可提升至44%(后验概率)。结论： 采用影像组学方法鉴定头颈部鳞状细胞癌患者HPV状态有较高的实用价值。

关键词: 头颈部鳞状细胞癌, 人乳头瘤病毒, 影像组学, 诊断性meta分析

Abstract: PURPOSE: To evaluate the value of human papillomavirus (HPV) status in patients with head and neck squamous cell carcinoma (HNSCC) using diagnostic meta-analysis based on radiomics. METHODS: PubMed, Embase, Web of Science, CNKI and VIP databases were searched for literatures related to radiomics identification of HPV status. The retrieval time was from the establishment of the database to May 28, 2022. Statistical software such as Revman 5.4 was used to evaluate the diagnostic performance of the prediction model. RESULTS: A total of 9 papers, including 3312 patients, were included in this study. The combined results showed that the sensitivity, specificity and positive likelihood ratio of radiomic-based methods in the diagnosis of HPV status were 0.82[95%CI(0.74,0.87)], 0.66[95%CI(0.54,0.75)] and 2.4[95%CI(1.8,3.1)], respectively. The negative likelihood ratio was 0.28[95%CI(0.21,0.36)], the diagnostic odds ratio was 9[95%CI(6,12)], and the area under the receiver operating characteristic curve (AUC) was 0.82[95%CI(0.78,0.85)]. HPV status was identified by imaging histochemistry with a 25% pretest probability, which was elevated to 44%(post-test probability). CONCLUSIONS: The radiomics method has high practical value in identification of HPV status in patients with HNSCC.

Key words: Head and neck squamous cell carcinoma, Human Papillomavirus, Radiomics, Diagnostic meta-analysis

中图分类号:

R739.8

李雪儿, 王正业, 买买提吐逊·吐尔地. 基于影像组学鉴定头颈部鳞状细胞癌患者HPV状态：诊断性meta分析[J]. 中国口腔颌面外科杂志, 2023, 21(1): 69-74.

LI Xue-er, WANG Zheng-ye, TUERDI Maimaitituxun. Identification of HPV status in head and neck squamous cell carcinoma patients based on radiomics: diagnostic meta-analysis[J]. China J Oral Maxillofac Surg, 2023, 21(1): 69-74.

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基于影像组学鉴定头颈部鳞状细胞癌患者HPV状态：诊断性meta分析

Identification of HPV status in head and neck squamous cell carcinoma patients based on radiomics: diagnostic meta-analysis

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