经皮穴位电刺激防治口腔鳞癌患者诱导化疗后骨髓抑制的效果观察

doi:10.19438/j.cjoms.2022.05.007

中国口腔颌面外科杂志 ›› 2022, Vol. 20 ›› Issue (5): 455-460.doi: 10.19438/j.cjoms.2022.05.007

经皮穴位电刺激防治口腔鳞癌患者诱导化疗后骨髓抑制的效果观察

季萍萍¹, 李莉², 吴奕帆³, 侯黎莉³

1.上海交通大学护理学院,上海 200025;
2.上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科,3.护理部,上海 200011

收稿日期:2022-01-19 修回日期:2022-05-22 出版日期:2022-09-20 发布日期:2022-09-20
通讯作者: 侯黎莉,E-mail：pisces_liz@163.com
作者简介:季萍萍（1996-）,女,在读硕士研究生,E-mail：1057137713@qq.com
基金资助:
上海市2021年度“科技创新行动计划”长三角科技创新共同体领域项目（21002411300）; 上海交通大学医学院附属第九人民医院护理院级基金（JYHL2020MS12）

Effect of transcutaneous electrical acupoint stimulation on myelosuppression in patients with oral squamous cell carcinoma after induction chemotherapy

JI Ping-ping¹, LI Li², WU Yi-fan³, HOU Li-li³

1. Shanghai Jiao Tong University School of Nursing. Shanghai 200025;
2. Department of Oromaxillofacial Head and Neck Oncology,3. Department of Nursing, Shanghai Ninth People Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200011, China

Received:2022-01-19 Revised:2022-05-22 Online:2022-09-20 Published:2022-09-20

摘要/Abstract

摘要： 目的: 观察经皮穴位电刺激对口腔鳞癌患者诱导化疗后骨髓抑制的影响。方法: 选择94例初次接受多西他赛、顺铂、5氟尿嘧啶诱导化疗方案的口腔鳞癌患者,随机分为试验组与对照组各47例。试验组在常规治疗基础上给予经皮穴位电刺激,对照组在常规治疗基础上给予安慰刺激,共干预2个化疗周期。比较2组患者2次化疗周期中白细胞、血红蛋白、血小板及中性粒细胞计数、骨髓抑制分度、抗骨髓抑制药物使用情况及疲乏状况评分。采用SPSS 25.0软件包对数据进行统计学分析。结果: 第2次化疗周期中,化疗第6天,试验组患者血红蛋白、血小板、中性粒细胞计数及化疗第13天血小板计数显著高于对照组（P<0.05）;第2次化疗周期中,2组患者骨髓抑制分度比较,试验组严重程度显著低于对照组（P<0.05）;2次化疗周期内,2组患者抗骨髓抑制药物使用情况比较,差异无统计学意义（P>0.05）。试验组患者疲乏总分在首次化疗周期第13天,第2次化疗周期化疗前1天、化疗第6天及第13天显著低于对照组（P<0.05）。结论: 经皮穴位电刺激有助于稳定口腔鳞癌患者化疗后血液指标计数水平,减轻骨髓抑制严重程度,同时缓解其疲乏症状。

关键词: 口腔鳞癌, 诱导化疗, 穴位疗法, 电刺激疗法, 骨髓抑制, 疲乏

Abstract: PURPOSE: To observe the effect of transcutaneous electrical acupoint stimulation on myelosuppression in patients with oral squamous cell carcinoma (OSCC) after induction chemotherapy. METHODS: A total of 94 patients with OSCC who received docetaxel, cisplatin, and 5-fluorouracil induction chemotherapy for the first time were selected and randomly divided into the experimental group and the control group, with 47 cases in each group. Patients in the experimental group were given transcutaneous electrical acupoint stimulation intervention on the basis of conventional treatment, while patients in the control group were given placebo/sham stimulation on the basis of conventional treatment, and were intervened for two cycles of chemotherapy. The counts of white blood cells, hemoglobin, platelets and neutrophils, the grades of myelosuppression, the use of anti-myelosuppressive drugs and the scores of fatigue status were compared between the two groups of patients during the two chemotherapy cycles. SPSS 25.0 software package was used for data analysis. RESULTS: In the second chemotherapy cycle, the hemoglobin, platelet and neutrophil counts on the 6th day of chemotherapy and the platelet count on the 13th day of chemotherapy in the experimental group were significantly higher than those in the control group(P<0.05). In the second chemotherapy cycle, the difference of myelosuppression grades between the two groups was statistically significant(P<0.05), the severity of patients in the experimental group was significantly lower than that in the control group. There was no significant difference in the use of anti-myelosuppressive drugs between the two groups of patients during the two chemotherapy cycles(P>0.05). The total score of fatigue in the experimental group was significantly lower than that in the control group on the 13th day of the first chemotherapy cycle, one day before the second chemotherapy cycle, on the 6th and 13th day of chemotherapy, and the differences were statistically significant(P<0.05). CONCLUSIONS: Transcutaneous electrical acupoint stimulation can help to stabilize the blood index count level of OSCC patients after chemotherapy, reduce the severity of myelosuppression, and relieve their fatigue symptoms.

Key words: Oral squamous cell carcinoma, Induction chemotherapy, Acupoint therapy, Electrical stimulation therapy, Myelosuppression, Fatigue

中图分类号:

R739.8

季萍萍, 李莉, 吴奕帆, 侯黎莉. 经皮穴位电刺激防治口腔鳞癌患者诱导化疗后骨髓抑制的效果观察[J]. 中国口腔颌面外科杂志, 2022, 20(5): 455-460.

JI Ping-ping, LI Li, WU Yi-fan, HOU Li-li. Effect of transcutaneous electrical acupoint stimulation on myelosuppression in patients with oral squamous cell carcinoma after induction chemotherapy[J]. China J Oral Maxillofac Surg, 2022, 20(5): 455-460.

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经皮穴位电刺激防治口腔鳞癌患者诱导化疗后骨髓抑制的效果观察

Effect of transcutaneous electrical acupoint stimulation on myelosuppression in patients with oral squamous cell carcinoma after induction chemotherapy

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