中国口腔颌面外科杂志

中国口腔颌面外科杂志 ›› 2018, Vol. 16 ›› Issue (3): 205-208.doi: 10.19438/j.cjoms.2018.03.003

• 论著 • 上一篇    下一篇

C/Gd纳米复合物用于兔舌间质磁共振淋巴造影的应用价值评价

单俊1，曾文霞2，刘世恩3,徐豪越1，朱海涛 2，宋凯1，冯元勇1,吴大雄2*,尚伟1*   

  1. 1.青岛大学附属医院口腔颌面外科，山东青岛266003；
    2.青岛科技大学材料科学与工程学院，山东青岛266042；
    3.青岛大学附属医院放射科，山东青岛266003
  • 收稿日期:2017-12-14 修回日期:2018-01-16 出版日期:2018-05-20 发布日期:2018-06-12
  • 作者简介:单俊（1990-），男，在读硕士研究生，E-mail：15562740553@163.com
  • 基金资助:
    国家自然科学基金（51472134）

Evaluation of the application value of cervical lymphatic imaging of the tongue interstitial magnetic resonance lymphography by submucosal injection of C/Gd nanocomposite

SHAN Jun1, ZENG Wen-xia2, LIU Shi-en3, XU Hao-yue1, ZHU Hai-tao2, SONG Kai1, FENG Yuan-yong1, WU Da-xiong2, SHANG Wei1.   

  1. 1.Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Qingdao University. Qingdao 266003;
    2.College of Materials Science and Engineering, Qingdao University of Science and Technology. Qingdao 266042;
    3.Department of Radiology, Affiliated Hospital of Qingdao University. Qingdao 266003, Shandong Province, China
  • Received:2017-12-14 Revised:2018-01-16 Online:2018-05-20 Published:2018-06-12

摘要： 目的： 探讨新型淋巴造影剂C/Gd纳米复合物经兔舌黏膜下注射后间质磁共振颈淋巴显影的应用价值。方法： 选择健康纯种成年新西兰大白兔12只，在大白兔左右两侧舌缘中后1/3交界黏膜下各注射0.2 mL C/Gd纳米复合物，按摩注射部位30 s。分别于注射造影剂前及注射、按摩后5、10、15、20、40 min进行三维增强磁共振淋巴造影成像。测量增强前、后不同时间段引流区颈淋巴结的信号强度，计算对应时间的信号强化率(E%)，采用SPSS17.0软件包对数据进行统计学分析。结果： C/Gd纳米复合物迅速进入引流区，可清晰显影兔颈部淋巴结及淋巴管，无明显血管显影。颈部淋巴结在注射造影剂后约10 min信号强度达到峰值，注射后5～20 min可获得最佳显影效果，40 min后影像基本廓清。结论： C/Gd纳米复合物作为间质磁共振显影剂，能以较小剂量快速有效地显示颈部淋巴结及淋巴管的形态及走行特征。

关键词: 颈部淋巴结, 纳米碳, 间质淋巴造影, 钆, 新西兰大白兔

Abstract: PURPOSE: To investigate the application value of cervical lymphatic imaging enhanced by submucosal injection of C/Gd nanocomposite as a new lymphoid contrast agent in interstitial magnetic resonance lymphography (IMRLG). METHODS: 0.2 mL C/Gd nanocomposite was injected into the bilateral tongue submucosa in 12 healthy New Zealand white rabbits and then massaged the injection site for 30 s. MR images were obtained before injection and 5,10,15,20 and 40 mins after injection by using 3D enhancement magnetic resonance lymphography. The signal intensities were measured to calculate the enhancing rates (E%) and the signal enhancing rates-time curve was drawn before and after enhancing of cervical lymph nodes. The data were statistically analyzed by using SPSS17.0 software package. RESULTS: After injection, C/Gd nanocomposite was rapidly absorbed into the cervical drainage area. The lymph nodes and lymphatic vessels were strengthened significantly; however, the blood vessels were not displayed at the same time. The enhancing rates of the cervical lymph nodes reached a peak 10 mins after injection, and the best enhancing effect was between 5 mins and 20 mins. It would not be able to distinguish from that of the surrounding tissues. CONCLUSIONS: As an IMRLG contrast agent, C/Gd nanocomposite can characteristically display the cervical lymph node morphology and lymphatic shape effectively with a small dose.

Key words: Cervical lymph node, Nano-carbon, Interstitial lymphography, Gadolinium, New Zealand white rabbit

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