平阳霉素联合激素治疗肉芽肿性唇炎的临床疗效评价

doi:10.19438/j.cjoms.2018.02.012

中国口腔颌面外科杂志 ›› 2018, Vol. 16 ›› Issue (2): 157-161.doi: 10.19438/j.cjoms.2018.02.012

平阳霉素联合激素治疗肉芽肿性唇炎的临床疗效评价

顾玲, 黄迪炎, 付崇建, 王昭领, 王栋, 杨璐, 朱国雄

济南军区总医院口腔科,山东济南 250031;

收稿日期:2017-12-20 修回日期:2018-01-18 出版日期:2018-03-20 发布日期:2018-04-08
通讯作者: 朱国雄, E-mail: jnjqzgx@163.com
作者简介:顾玲（1974-）,女,博士,主治医师,E-mail: 54478270@qq.com
基金资助:
2015年院长基金面上项目（2015MS12）

Investigation of the treatment effect of pingyangmycin plus corticosteroids on cheilitis granulomatosa

GU Ling, HUANG Di-yan, FU Chong-jian, WANG Zhao-ling, WANG Dong, YANG Lu, ZHU Guo-xiong

Department of Stomatology, General Hospital of Jinan Military Command. Jinan 250031, Shandong Province, China;

Received:2017-12-20 Revised:2018-01-18 Online:2018-03-20 Published:2018-04-08

摘要/Abstract

摘要： 目的: 探讨平阳霉素联合激素治疗肉芽肿性唇炎的临床疗效。 方法: 选取2008年3月—2016年3月在济南军区总医院口腔科就诊的肉芽肿性唇炎患者78例,行平阳霉素联合激素局部注射治疗,对治疗前、后的病例进行对比,评价治疗效果。 结果: 肉芽肿性唇炎患者78例,均接受了对患唇的平阳霉素联合地塞米松局部注射治疗,治疗次数1~5次不等,平均3次。73例患者治愈,5例好转。所有病例唇肿胀均得到改善,部分病例面部肿胀亦得到一定程度缓解。 结论: 平阳霉素联合激素局部注射治疗肉芽肿性唇炎,安全、经济、有效,能改善唇部顽固性肿胀并达到理想的美观效果。

关键词: 肉芽肿性唇炎, 梅-罗综合征, 平阳霉素, 激素, 地塞米松

Abstract: PURPOSE: To explore the treatment effect of pingyangmycin plus corticosteroids on cheilitis granulomatosa. METHODS: A retrospective study on 78 patients with cheilitis granulomatosa treated by a new method at our hospital between March 2008 and March 2016 was performed. Pretherapeutic and post-therapeutic medical histories were obtained, and criteria for the success of treatment were evaluated. The outcomes and effects of therapy were analyzed. RESULTS: All patients received intralesional injection of pingyangmycin plus dexamethasone. The number of injections ranged from 1 to 5, with a median of 3 injections. The outcomes were encouraging. Seventy-three cases were cured, 5 cases were improved and none was found ineffective. Swelling of the lips subsided and the skin color returned to normal in all cases. In cases of orofacial involvement, facial asymmetry and orofacial swelling were removed to attain a good esthetic appearance. CONCLUSIONS: The results demonstrated positive responses to the treatment. It is a safe, effective and inexpensive treatment to correct persistent labial swelling and improve lip aesthetics.

Key words: Cheilitis granulomatosa, Melkersson-Rosenthal syndrome, Pingyangmycin, Corticosteroids, Dexamethasone

中图分类号:

R781.5.6

顾玲, 黄迪炎, 付崇建, 王昭领, 王栋, 杨璐, 朱国雄. 平阳霉素联合激素治疗肉芽肿性唇炎的临床疗效评价[J]. 中国口腔颌面外科杂志, 2018, 16(2): 157-161.

GU Ling, HUANG Di-yan, FU Chong-jian, WANG Zhao-ling, WANG Dong, YANG Lu, ZHU Guo-xiong. Investigation of the treatment effect of pingyangmycin plus corticosteroids on cheilitis granulomatosa[J]. China J Oral Maxillofac Surg, 2018, 16(2): 157-161.

参考文献

[1] Achauer BM, Chang CJ, Vander Kam VM.Management of hemangioma of infancy: review of 245 patients[J]. Plast Reconstr Surg, 1997, 99(5): 1301-1308.
[2] Nagel F, Foelster-Holst R.[Cheilitis granulomatosa Melkersson-Rosenthal syndrome][J]. Hautarzt, 2006, 57(2): 121-126.
[3] Ridder GJ, Fradis M, Lohle E.Cheilitis granulomatosa Miescher: treatment with clofazimine and review of the literature[J]. Ann Otol Rhinol Laryngol, 2001, 110(10): 964-967.
[4] Rehor G, Braun-Falco M, Nashan D, et al.[Cheilitis granulomatosa as initial manifestation of Crohn's disease][J]. Hautarzt, 2010, 61(8): 691-693.
[5] Shehade SA, Foulds IS.Granulomatous cheilitis and a positive Kveim test[J]. Br J Dermatol, 1986, 115(5): 619-622.
[6] Wiesenfeld D, Ferguson MM, Mitchell DN, et al.Oro-facial granulomatosis-a clinical and pathological analysis[J]. Q J Med, 1985, 54(213): 101-113.
[7] Dhar S, Kanwar AJ.Melkersson-Rosenthal syndrome in India: experience with six cases[J]. J Dermatol, 1995, 22(2): 129-133.
[8] Bohra S, Kariya PB, Bargale SD, et al. Clinicopathological significance of Melkersson-Rosenthal syndrome [J]. BMJ Case Rep, 2015, pii: bcr2015210138.
[9] Cocuroccia B, Gubinelli E, Annessi G, et al.Persistent unilateral orbital and eyelid oedema as a manifestation of Melkersson-Rosenthal syndrome[J]. J Eur Acad Dermatol Venereol, 2005, 19(1): 107-111.
[10] Rozen TD.Melkersson-Rosenthal syndrome presenting as a new daily persistent headache: relief with dapsone[J]. Cephalalgia, 2001, 21(9): 924-925.
[11] Fdez-Freire LR, Serrano Gotarredona A, Bernabeu Wittel J, et al.Clofazimine as elective treatment for granulomatous cheilitis[J]. J Drugs Dermatol, 2005, 4(3): 374-377.
[12] Sussman GL, Yang WH, Steinberg S.Melkersson-Rosenthal syndrome: clinical, pathologic, and therapeutic considerations[J]. Ann Allergy, 1992, 69(3): 187-194.
[13] Ratzinger G, Sepp N, Vogetseder W, et al.Cheilitis granulomatosa and Melkersson-Rosenthal syndrome: evaluation of gastrointestinal involvement and therapeutic regimens in a series of 14 patients[J]. J Eur Acad Dermatol Venereol, 2007, 21(8): 1065-1070.
[14] Lopez-Urbano MJ, Villar MA, Ruiz Villaverde R, et al.Granulomatous cheilitis: a condition that merits inclusion in the differential diagnosis of angioedema[J]. J Investig Allergol Clin Immunol, 2009, 19(1): 68-70.
[15] Miralles J, Barnadas MA, de Moragas JM. Cheilitis granulomatosa treated with metronidazole[J]. Dermatology, 1995, 191(3): 252-253.
[16] Lamey PJ, Lewis MA.Oral medicine in practice: orofacial allergic reactions[J]. Br Dent J, 1990, 168(2): 59-63.
[17] Morales C, Penarrocha M, Bagan JV, et al.Immunological study of Melkersson-Rosenthal syndrome. Lack of response to food additive challenge[J]. Clin Exp Allergy, 1995, 25(3): 260-264.
[18] van der Waal RI, Schulten EA, van der Meij EH, et al. Cheilitis granulomatosa: overview of 13 patients with long-term follow-up-results of management[J]. Int J Dermatol, 2002, 41(4): 225-229.
[19] Camacho F, Garcia-Bravo B, Carrizosa A.Treatment of Miescher's cheilitis granulomatosa in Melkersson-Rosenthal syndrome[J]. J Eur Acad Dermatol Venereol, 2001, 15(6): 546-549.
[20] Yang Y, Sun M, Ma Q, et al.Bleomycin A5 sclerotherapy for cervicofacial lymphatic malformations[J]. J Vasc Surg, 2011, 53(1): 150-155.
[21] Mai HM, Zheng JW, Zhou Q, et al.Intralesional injection of pingyangmycin is a safe and effective treatment for microcystic lymphatic malformations in the tongue[J]. Phlebology, 2013, 28(3): 147-152.
[22] 黄迪炎, 张文, 朱建军, 等. 平阳霉素治疗肉芽肿性唇炎的临床效果[J]. 前卫医药杂志, 1999, 16(5): 296.
[23] 张树标, 王敬旭, 潘广嗣, 等. 平阳霉素治疗肉芽肿性唇炎的效果观察[J]. 广东牙病防治, 2006, 14(2): 116-117.
[24] Gu L, Huang DY, Fu CJ, et al.Successful treatment of cheilitis granulomatosa by intralesional injections of pingyangmycin plus dexamethasone[J]. Eur J Dermatol, 2016, 26(6): 627-628.
[25] Gu L, Huang DY, Fu CJ, et al.Intralesional injection of Pingyangmycin plus corticosteroids may be an effective treatment for cheilitis granulomatosa[J]. Med Hypotheses, 2013, 81(4): 729-730.
[26] Orford J, Barker A, Thonell S, et al.Bleomycin therapy for cystic hygroma[J]. J Pediatr Surg, 1995, 30(9): 1282-1287.
[27] Zhong PQ, Zhi FX, Li R, et al.Long-term results of intratumorous bleomycin-A5 injection for head and neck lymphangioma[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998, 86(2): 139-144.
[28] Bai Y, Jia J, Huang XX, et al.Sclerotherapy of microcystic lymphatic malformations in oral and facial regions[J]. J Oral Maxillofac Surg, 2009, 67(2): 251-256.

平阳霉素联合激素治疗肉芽肿性唇炎的临床疗效评价

Investigation of the treatment effect of pingyangmycin plus corticosteroids on cheilitis granulomatosa

PDF (PC)

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 11

编辑推荐

Metrics

本文评价

[1]	邰茂众, 陈涛, 李克雷, 葛春晓, 徐振国, 秦中平. 2种病变内平阳霉素注射方法治疗68例儿童唇面部微囊型淋巴管畸形疗效分析[J]. 中国口腔颌面外科杂志, 2022, 20(3): 268-272.
[2]	陈邢玉, 董非斐, 李凯. 甲状腺激素对小鼠面神经损伤轴突再生及神经电生理功能的影响[J]. 中国口腔颌面外科杂志, 2021, 19(4): 320-324.
[3]	杨柳笛, 黄龙, 苏彤. 泼尼松治愈下颌骨炎性肌纤维母细胞瘤1例报告[J]. 中国口腔颌面外科杂志, 2020, 18(6): 574-576.
[4]	靳能皓, 南欣荣, 闫星泉, 李明. 手术结合平阳霉素注射治疗巨舌症1例报告[J]. 中国口腔颌面外科杂志, 2020, 18(2): 190-192.
[5]	刘学键, 刘志鹏, 武宜雷, 邰茂众. 平阳霉素新剂型瘤体内注射治疗婴幼儿血管瘤203例临床分析[J]. 中国口腔颌面外科杂志, 2019, 17(3): 247-250.
[6]	闫志伟, 张春谊, 郭军, 杨霞, 王维戚, 杨涛, 孙沫逸, 杨耀武. 纤维蛋白胶复合平阳霉素栓塞硬化治疗面颈部动静脉畸形效果观察[J]. 中国口腔颌面外科杂志, 2018, 16(1): 52-55.
[7]	王亚飞, 王忠强. 糖皮质激素联合聚桂醇泡沫硬化剂治疗卡-梅综合征（现象）16例临床分析[J]. 中国口腔颌面外科杂志, 2016, 14(6): 557-561.
[8]	董依云, 周国瑜, 沈玲悦, 徐青, 顾基中. 口服糖皮质激素联合长脉宽1064 nm Nd:YAG激光治疗婴幼儿颌面部溃疡型血管瘤3年临床观察[J]. 中国口腔颌面外科杂志, 2015, 13(1): 48-53.
[9]	沈时岳;邬腊梅;杨宏宇;罗娟;王锋;苏铭扬;. 小剂量平阳霉素早期干预婴幼儿腮腺血管瘤疗效分析 [J]. 中国口腔颌面外科杂志, 2013, 11(4): 340-344.
[10]	杨擎天;杨耀武;孙沫逸;雷德林;刘桂才;王维戚;陈澄;郭军;石利强;刘宝林 . 纤维蛋白胶复合平阳霉素栓塞硬化治疗面颈部静脉畸形的远期疗效观察 [J]. 中国口腔颌面外科杂志, 2013, 11(3): 238-242.
[11]	王佳;陈传俊. 髁突特发性吸收的研究现状 [J]. 中国口腔颌面外科杂志, 2013, 11(2): 165-168.