浓缩生长因子联合自体骨和Bio-Oss在下颌第三磨牙拔除后牙槽骨修复中的效果评价

doi:10.19438/j.cjoms.2024.06.005

中国口腔颌面外科杂志 ›› 2024, Vol. 22 ›› Issue (6): 547-552.doi: 10.19438/j.cjoms.2024.06.005

浓缩生长因子联合自体骨和Bio-Oss在下颌第三磨牙拔除后牙槽骨修复中的效果评价

孙守福^1,*, 潘昱帆^2,*, 唐渔¹, 王伟^1#, 蒋雪薇^1#, 蒋雨楠¹

1.上海市同仁医院·上海交通大学医学院附属同仁医院口腔科,上海 200336;
2.上海市仙霞街道社区卫生服务中心口腔科,上海 200336

收稿日期:2024-02-05 修回日期:2024-04-15 出版日期:2024-11-20 发布日期:2024-12-11
通讯作者: 王伟,E-mail：ww0936@shtrhospital.com;蒋雪薇,E-mail：jxw4959@shtrhospital.com。^#共同通信作者
作者简介:孙守福（1990-）,男,硕士,主治医师,E-mail：sunshoufu@163.com;潘昱帆（1990-）,女,本科,E-mail：1014812608@qq.com。^*并列第一作者
基金资助:
上海市长宁区科学技术委员会资助项目（CNKW2020Y10）; 上海市仙霞街道社区卫生服务中心霞光人才培养项目; 上海市同仁医院青年骨干医师培养项目（TRGG202104）

The clinical effect of concentrate growth factor combined with autogenous bone and Bio-Oss on the long-term stability of alveolar bone repair after mandibular third molar extraction

SUN Shou-fu¹, PAN Yu-fan², TANG Yu¹, WANG Wei¹, JIANG Xue-wei¹, JIANG Yu-nan¹

1. Department of Stomatology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine. Shanghai 200336;
2. Department of Stomatology, Xianxia Community Care Center. Shanghai 200336, China

Received:2024-02-05 Revised:2024-04-15 Online:2024-11-20 Published:2024-12-11

摘要/Abstract

摘要： 目的： 评价下颌第三磨牙拔除后,应用浓缩生长因子（concentrate growth factors,CGF）联合自体骨和Bio-Oss修复牙槽骨的临床效果。方法： 选择2020年9月—2021年12月在上海市同仁医院拔除下颌第三磨牙的患者66例,将其分为空白组（n=22）、试验组A（自体骨、Bio-Oss和口腔修复膜,n=23）、试验组B（自体骨、Bio-Oss、CGF凝胶+CGF膜,n=21）。采用术后症状严重度量表(PoSSe)评估术后1周3组患者的临床症状,并测量术后3、6、12个月时第二磨牙远中牙周袋探诊深度（probe depth,PD）、骨吸收的垂直距离和水平距离。采用SPSS 19.0软件包对数据进行统计学分析。结果： CGF可以显著减少拔牙后疼痛时间（P<0.05）。试验组B的PD在术后3、6、12个月时显著小于空白组（P<0.05）,12个月时显著小于试验组A（P<0.05）;术后3、6个月,试验组B的骨缺损吸收垂直高度显著低于试验组A（P<0.05）。骨缺损吸收水平距离方面,术后3、6、12个月,2个试验组的结果均显著低于空白组（P<0.05）;术后3个月,试验组B显著低于试验组A（P<0.05）;术后6、12个月,2组无显著差异（P>0.05）。结论： 自体骨和Bio-Oss在下颌第三磨牙拔除后牙槽骨的修复中可取得良好效果,但CGF联合自体骨、Bio-Oss有更好的临床疗效,更值得推荐。

关键词: 下颌第三磨牙, 骨缺损, 浓缩生长因子, Bio-Oss, 牙周袋探诊深度, PoSSe

Abstract: PURPOSE: To evaluate the clinical efficacy of concentrate growth factors(CGF) combined with autobone and Bio-Oss in the long-term stability of alveolar bone repair after mandibular third molar extraction. METHODS: Sixty-six patients who underwent extraction of mandibular third molars at Tongren Hospital of Shanghai Municipality from September 2020 to December 2021 were selected and divided into 3 groups, blank group(n=22), experimental group A (autogenous bone, Bio-Oss, and oral repair film, n=23), and experimental group B(autogenous bone, Bio-Oss, CGF gel + CGF film, n=21). The Postoperative Symptom Severity Scale (PoSSe) was used to assess the clinical symptoms of the 3 groups of patients 1 week postoperatively. Additionally, probing depth (PD), vertical and horizontal distances of bone resorption were measured 3, 6, and 12 months postoperatively for the distal aspect of the second molar. SPSS 19.0 software package was used for data analysis. RESULTS: CGF could significantly reduce the pain time after tooth extraction (P<0.05). PD of the experimental group B was significantly lower than that of the blank group 3, 6 and 12 months after surgery(P<0.05), and significantly lower than that of the experimental group A 12 months postoperatively(P<0.05). At 3 and 6 months after operation, the vertical height of bone defect absorption in the experimental group B was significantly lower than that in the experimental group A(P<0.05). In terms of the horizontal distance of bone defect absorption, at 3, 6 and 12 months after surgery, the results of the experimental group B were significantly lower than those of the blank group(P<0.05); at 3 months after surgery, the experimental group B was significantly lower than the experimental group A(P<0.05), but at 6 and 12 months after surgery, there was no significant difference between the two groups (P>0.05). CONCLUSIONS: Autologous bone and Bio-Oss can achieve good results in restoration of alveolar bone after mandibular third molar extraction, but CGF combined with autologous bone and Bio-Oss has better clinical efficacy and is worthy of recommendation.

Key words: Mandibular third molar, Bone defect, CGF, Bio-Oss, Probing depth, PoSSe

中图分类号:

R782.1

孙守福, 潘昱帆, 唐渔, 王伟, 蒋雪薇, 蒋雨楠. 浓缩生长因子联合自体骨和Bio-Oss在下颌第三磨牙拔除后牙槽骨修复中的效果评价[J]. 中国口腔颌面外科杂志, 2024, 22(6): 547-552.

SUN Shou-fu, PAN Yu-fan, TANG Yu, WANG Wei, JIANG Xue-wei, JIANG Yu-nan. The clinical effect of concentrate growth factor combined with autogenous bone and Bio-Oss on the long-term stability of alveolar bone repair after mandibular third molar extraction[J]. China J Oral Maxillofac Surg, 2024, 22(6): 547-552.

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浓缩生长因子联合自体骨和Bio-Oss在下颌第三磨牙拔除后牙槽骨修复中的效果评价

The clinical effect of concentrate growth factor combined with autogenous bone and Bio-Oss on the long-term stability of alveolar bone repair after mandibular third molar extraction

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