以吞咽困难为首发症状的AL型舌淀粉样变合并多发性骨髓瘤1例报告

doi:10.19438/j.cjoms.2023.01.017

中国口腔颌面外科杂志 ›› 2023, Vol. 21 ›› Issue (1): 97-101.doi: 10.19438/j.cjoms.2023.01.017

以吞咽困难为首发症状的AL型舌淀粉样变合并多发性骨髓瘤1例报告

陈霖^1,2,3, 陈寅瑜^1,2,3, 丁紫雪^1,2, 孟箭^1,2,3

1.徐州医科大学徐州临床学院,江苏徐州 221000;
2.徐州市中心医院口腔颌面外科,江苏徐州 221000;
3.徐州医科大学口腔医学院,江苏徐州 221000

收稿日期:2022-07-22 修回日期:2022-10-19 出版日期:2023-01-20 发布日期:2023-06-12
通讯作者: 孟箭,E-mail: mrocket@126.com
作者简介:陈霖（1997-）,男,在读硕士研究生,E-mail:859749173@qq.com
基金资助:
徐州市重点研发计划（20210230）

A case report of AL amyloidosis complicated with multiple myeloma with dysphagia as the first symptom

CHEN Lin^1,2,3, CHEN Yin-yu^1,2,3, DING Zi-xue^1,2, MENG Jian^1,2,3

1. Xuzhou Clinical College of Xuzhou Medical University. Xuzhou 221000;
2. Department of Stomatology, Xuzhou Central Hospital. Xuzhou 221000;
3. School of Stomatology, Xuzhou Medical University. Xuzhou 221000, Jiangsu Province, China

Received:2022-07-22 Revised:2022-10-19 Online:2023-01-20 Published:2023-06-12

摘要/Abstract

摘要： 系统性轻链型（AL）淀粉样变性（amyloidosis）合并多发性骨髓瘤（multiple myeloma,MM）是一种临床上罕见的浆细胞相关恶性疾病。大多数患者因心脏、肾脏功能损伤或实质性骨髓瘤为主诉就诊,以吞咽困难或其他口腔相关疾病为首发症状的病例罕见,故初诊时易漏诊误诊。本文报告1例以吞咽困难为首发症状的淀粉样变性合并多发性骨髓瘤病例,结合相关文献,对该病的特点、诊断标准及治疗方法进行讨论。

关键词: 淀粉样变, 多发性骨髓瘤, 吞咽困难, 舌疾病, 口腔颌面部

Abstract: Systemic light-chain-type amyloidosis combined with multiple myeloma(MM) is a clinically rare plasma cell-associated malignant disease. Most of the patients with this disease are complained for heart/renal impairment or substantial myeloma, and very few cases presented dysphagia or other oral related diseases as the first symptom, so it is easy to miss diagnosis or make misdiagnosis during first visit. Therefore, the diagnosis and treatment of amyloidosis with dysphagia was reported in the article. Based on the relevant literature review, the characteristics, diagnostic criteria and treatment of the disease were discussed.

Key words: Amyloidosis, Multiple myeloma, Dysphagia, Diseases of tongue, Oromaxillofacial region

中图分类号:

R739.8

陈霖, 陈寅瑜, 丁紫雪, 孟箭. 以吞咽困难为首发症状的AL型舌淀粉样变合并多发性骨髓瘤1例报告[J]. 中国口腔颌面外科杂志, 2023, 21(1): 97-101.

CHEN Lin, CHEN Yin-yu, DING Zi-xue, MENG Jian. A case report of AL amyloidosis complicated with multiple myeloma with dysphagia as the first symptom[J]. China J Oral Maxillofac Surg, 2023, 21(1): 97-101.

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以吞咽困难为首发症状的AL型舌淀粉样变合并多发性骨髓瘤1例报告

A case report of AL amyloidosis complicated with multiple myeloma with dysphagia as the first symptom

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